Πλοήγηση ανά Συγγραφέα "Balatsos, N. A. A."
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Alterations of Deadenylase Expression in Acute Leukemias: Evidence for Poly(A)-Specific Ribonuclease as a Potential Biomarker
Maragozidis, P.; Karangeli, M.; Labrou, M.; Dimoulou, G.; Papaspyrou, K.; Salataj, E.; Pournaras, S.; Matsouka, P.; Gourgoulianis, K. I.; Balatsos, N. A. A. (2012)Background/Aims: The degradation of mRNA is a key process in the control of gene expression correlated to anomalous cell proliferation. The rate-limiting step of mRNA degradation is the removal of the poly(A) tail by ... -
Competitive Inhibition of Human Poly(A)-Specific Ribonuclease (PARN) by Synthetic Fluoro-Pyranosyl Nucleosides
Balatsos, N. A. A.; Vlachakis, D.; Maragozidis, P.; Manta, S.; Anastasakis, D.; Kyritsis, A.; Vlassi, M.; Komiotis, D.; Stathopoulos, C. (2009)Poly(A)-specific ribonuclease (PARN) is a cap-interacting deadenylase that mediates, together with other exonucleases, the eukaryotic mRNA turnover and thus is actively involved in the regulation of gene expression. ... -
A Comprehensive Phylogenetic Analysis of Deadenylases
Pavlopoulou, A.; Vlachakis, D.; Balatsos, N. A. A.; Kossida, S. (2013)Deadenylases catalyze the shortening of the poly(A) tail at the messenger ribonucleic acid (mRNA) 3'-end in eukaryotes. Therefore, these enzymes influence mRNA decay, and constitute a major emerging group of promising ... -
Cysteinyl leukotriene receptors in tonsillar B- and T-lymphocytes from children with obstructive sleep apnea
Tsaoussoglou, M.; Lianou, L.; Maragozidis, P.; Hatzinikolaou, S.; Mavromati, M.; Orologas, N.; Panaghiotopoulou-Gartagani, P.; Rassidakis, G.; Balatsos, N. A. A.; Chrousos, G.; Kaditis, A. G. (2012)Objectives: Cysteinyl leukotrienes have been implicated in the pathogenesis of adenotonsillar hypertrophy in children with obstructive sleep apnea (OSA). This study aimed to quantify the expression of cysteinyl leukotriene ... -
Expression of Leukotriene Biosynthetic Enzymes in Tonsillar Tissue of Children With Obstructive Sleep Apnea A Prospective Nonrandomized Study
Tsaoussoglou, M.; Hatzinikolaou, S.; Baltatzis, G. E.; Lianou, L.; Maragozidis, P.; Balatsos, N. A. A.; Chrousos, G.; Kaditis, A. G. (2014)IMPORTANCE Cysteinyl leukotrienes (CysLTs) potentially promote adenotonsillar hypertrophy in children with obstructive sleep apnea (OSA). Previous studies have identified CysLTs and their receptors in tonsillar tissue from ... -
H2AX and lamin A/C interact dynamically in apoptosis indicating the existence of H2AX-organized machinery centers
Balatsos, N. A. A.; Fragkos-Livanios, L.; Xiao, Z.; Veenstra, T. D.; Panayotou, G.; Rogakou, E. P. (2008) -
H2AX dynamically interacts with lamin A/C indicating the existence of H2AX-organized machinery centers in response to DSB
Balatsos, N. A. A.; Fragkos-Livanios, L.; Xiao, Z.; Samiotaki, M.; Veenstra, T. D.; Panayotou, G.; Rogakou, E. P. (2007) -
Induction of apoptosis with staurosporine in knockout H2AX mouse embryonic stem cells results in chromatin relaxation and disorganization
Balatsos, N. A. A.; Fatouros, C. A.; Rogakou, E. P. (2008) -
Inhibition of human poly(A)-specific ribonuclease (PARN) by purine nucleotides: kinetic analysis
Balatsos, N. A. A.; Anastasakis, D.; Stathopoulos, C. (2009)Poly(A)-specific ribonuclease (PARN) is a cap-interacting and poly(A)-specific 3'-exoribonuclease that efficiently degrades mRNA poly(A) tails. Based on the enzyme's preference for its natural substrates, we examined the ... -
Inhibition of mRNA deadenylation by the nuclear cap binding complex (CBC)
Balatsos, N. A. A.; Nilsson, P.; Mazza, C.; Cusack, S.; Virtanen, A. (2006)Poly(A)-specific ribonuclease (PARN) is a cap-interacting and poly(A)-specific 3′-exoribonuclease. Here we have investigated how the cap binding complex (CBC) affects human PARN activity. We showed that CBC, via its 80-kDa ... -
An Integrated In Silico Approach to Design Specific Inhibitors Targeting Human Poly(A)-Specific Ribonuclease
Vlachakis, D.; Pavlopoulou, A.; Tsiliki, G.; Komiotis, D.; Stathopoulos, C.; Balatsos, N. A. A.; Kossida, S. (2012)Poly(A)-specific ribonuclease (PARN) is an exoribonuclease/deadenylase that degrades 3'-end poly(A) tails in almost all eukaryotic organisms. Much of the biochemical and structural information on PARN comes from the human ... -
Modulation of Poly(A)-specific Ribonuclease (PARN): Current Knowledge and Perspectives
Balatsos, N. A. A.; Maragozidis, P.; Anastasakis, D.; Stathopoulos, C. (2012)Deadenylation is the exoribonucleolytic shortening of eukaryotic poly(A) tails. It is often the first and rate-limiting step for mRNA decay and translational silencing. The process is catalysed by a diversity of deadenylases, ... -
A multifunctional RNA recognition motif in poly(A)-specific ribonuclease with cap and poly(A) binding properties
Nilsson, P.; Henriksson, N.; Niedzwiecka, A.; Balatsos, N. A. A.; Kokkoris, K.; Eriksson, J.; Virtanen, A. (2007)Poly(A)-specific ribonuclease (PARN) is an oligomeric, processive and cap-interacting 3′ exoribonuclease that efficiently degrades mRNA poly(A) tails. Here we show that the RNA recognition motif (RRM) of PARN harbors both ... -
SoTRIs: a novel fractionation procedure for cellular proteins that participate in functional complexes
Fragkos-Livanios, L.; Balatsos, N. A. A.; Xiao, Z.; Veenstra, T. D.; Panayotou, G.; Rogakou, E. P. (2008) -
Triazole pyrimidine nucleosides as inhibitors of Ribonuclease A. Synthesis, biochemical, and structural evaluation
Parmenopoulou, V.; Chatzileontiadou, D. S. M.; Manta, S.; Bougiatioti, S.; Maragozidis, P.; Gkaragkouni, D. N.; Kaffesaki, E.; Kantsadi, A. L.; Skamnaki, V. T.; Zographos, S. E.; Zounpoulakis, P.; Balatsos, N. A. A.; Komiotis, D.; Leonidas, D. D. (2012)Five ribofuranosyl pyrimidine nucleosides and their corresponding 1,2,3-triazole derivatives have been synthesized and characterized. Their inhibitory action to Ribonuclease A has been studied by biochemical analysis and ...