• Causes and Risk Factors of Cerebral Ischemic Events in Patients with Atrial Fibrillation Treated with Non-Vitamin K Antagonist Oral Anticoagulants for Stroke Prevention: The RENo Study 

      Paciaroni M., Agnelli G., Caso V., Silvestrelli G., Seiffge D.J., Engelter S., De Marchis G.M., Polymeris A., Zedde M.L., Yaghi S., Michel P., Eskandari A., Antonenko K., Sohn S.-I., Cappellari M., Tassinari T., Tassi R., Masotti L., Katsanos A.H., Giannopoulos S., Acciarresi M., Alberti A., Venti M., Mosconi M.G., Vedovati M.C., Pierini P., Giustozzi M., Lotti E.M., Ntaios G., Kargiotis O., Monaco S., Lochner P., Bandini F., Liantinioti C., Palaiodimou L., Abdul-Rahim A.H., Lees K., Mancuso M., Pantoni L., Rosa S., Bertora P., Galliazzo S., Ageno W., Toso E., Angelini F., Chiti A., Orlandi G., Denti L., Flomin Y., Marcheselli S., Mumoli N., Rimoldi A., Verrengia E., Schirinzi E., Del Sette M., Papamichalis P., Komnos A., Popovic N., Zarkov M., Rocco A., Diomedi M., Giorli E., Ciccone A., Grory B.C.M., Furie K.L., Bonetti B., Saia V., Guideri F., Acampa M., Martini G., Grifoni E., Padroni M., Karagkiozi E., Perlepe K., Makaritsis K., Mannino M., MacCarrone M., Ulivi L., Giannini N., Ferrari E., Pezzini A., Doronin B., Volodina V., Baldi A., D'Amore C., Deleu D., Corea F., Putaala J., Santalucia P., Nardi K., Risitano A., Toni D., Tsivgoulis G. (2019)
      Background and Purpose-Despite treatment with oral anticoagulants, patients with nonvalvular atrial fibrillation (AF) may experience ischemic cerebrovascular events. The aims of this case-control study in patients with AF ...
    • Characteristics and outcomes of Embolic Stroke of Undetermined Source according to stroke severity 

      Leventis I., Perlepe K., Sagris D., Sirimarco G., Strambo D., Georgiopoulos G., Eskandari A., Karagkiozi E., Vemmou A., Koroboki E., Manios E., Makaritsis K., Vemmos K., Michel P., Ntaios G. (2020)
      Background and aims: Patients with embolic strokes of undetermined source (ESUS) usually present with mild symptoms. We aimed to compare the baseline characteristics between mild and severe ESUS, identify predictors for ...
    • Clinical risk scores for the prediction of incident atrial fibrillation: a modernized review 

      Louka A.M., Tsagkaris C., Stoica A. (2021)
      Atrial fibrillation (AF) is considered the most common sustained arrhythmia. Major cardiovascular risk factors that have been identified to initiate and perpetuate AF include age, sex, arterial hypertension, heart failure, ...
    • Coexisting morbidity burden in elderly hospitalized patients with and without heart failure 

      Simou A., Xanthopoulos A., Giamouzis G., Papagiannis D., Dimos A., Economou D., Skoularigis J., Triposkiadis F. (2022)
      Introduction: Aging, cardiovascular disease (CVD), and heart failure (HF) increase the coexisting morbidity (CM) burden. This study compared the contribution of HF with this increase in elderly patients hospitalized for ...
    • A comparative analysis of ambulatory BP profile and arterial stiffness between CAPD and APD 

      Vaios V., Georgianos P.I., Vareta G., Dounousi E., Eleftheriadis T., Papagianni A., Zebekakis P.E., Liakopoulos V. (2022)
      Prior studies have associated automated peritoneal dialysis (APD) with less effective volume and blood pressure (BP) control as compared with continuous ambulatory peritoneal dialysis (CAPD). Our study aimed to compare the ...
    • COVID-19 pandemic and cardiovascular disease: where do we stand? 

      Chatzis D.G., Magounaki K.T., Pantazopoulos I.N., Johnson E.O., Tsioufis K.P. (2020)
      Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19) which recently has been characterized as a pandemic by the World Health Organization (WHO) having killed ...
    • D-dimer as a diagnostic tool for canine thromboembolic disorders [Τα Δ-διμερή ως διαγνωστικό μέσο θρομβοεμβολικών διαταραχών στο σκύλο] 

      Giannoulopoulos G.D., Athanasiou L.V., Polizopoulou Z.S. (2017)
      D-dimers are small protein fragments present in the blood after a blood clot is degraded by plasmin. During the fibrin(ogen) degradation, a number of products are produced called fibrin(ogen) degradation products (FDPs). ...
    • Data-driven machine-learning analysis of potential embolic sources in embolic stroke of undetermined source 

      Ntaios G., Weng S.F., Perlepe K., Akyea R., Condon L., Lambrou D., Sirimarco G., Strambo D., Eskandari A., Karagkiozi E., Vemmou A., Korompoki E., Manios E., Makaritsis K., Vemmos K., Michel P. (2021)
      Background and purpose: Hierarchical clustering, a common ‘unsupervised’ machine-learning algorithm, is advantageous for exploring potential underlying aetiology in particularly heterogeneous diseases. We investigated ...
    • Determinants of cognitive performance and decline in 20 diverse ethno-regional groups: A COSMIC collaboration cohort study 

      Lipnicki D.M., Makkar S.R., Crawford J.D., Thalamuthu A., Kochan N.A., Lima-Costa M.F., Castro-Costa E., Ferri C.P., Brayne C., Stephan B., Llibre-Rodriguez J.J., Llibre-Guerra J.J., Valhuerdi-Cepero A.J., Lipton R.B., Katz M.J., Derby C.A., Ritchie K., Ancelin M.-L., Carrière I., Scarmeas N., Yannakoulia M., Hadjigeorgiou G.M., Lam L., Chan W.-C., Fung A., Guaita A., Vaccaro R., Davin A., Kim K.W., Han J.W., Suh S.W., Riedel-Heller S.G., Roehr S., Pabst A., van Boxtel M., Köhler S., Deckers K., Ganguli M., Jacobsen E.P., Hughes T.F., Anstey K.J., Cherbuin N., Haan M.N., Aiello A.E., Dang K., Kumagai S., Chen T., Narazaki K., Ng T.P., Gao Q., Nyunt M.S.Z., Scazufca M., Brodaty H., Numbers K., Trollor J.N., Meguro K., Yamaguchi S., Ishii H., Lobo A., Lopez-Anton R., Santabárbara J., Leung Y., Lo J.W., Popovic G., Sachdev P.S., Cohort Studies of Memory in an International Consortium (COSMIC) (2019)
      Background: With no effective treatments for cognitive decline or dementia, improving the evidence base for modifiable risk factors is a research priority. This study investigated associations between risk factors and ...
    • Diagnosis and treatment of acute isolated proximal internal carotid artery occlusions: a narrative review 

      Kargiotis O., Psychogios K., Safouris A., Spiliopoulos S., Karapanayiotides T., Bakola E., Mantatzis M., Dardiotis E., Ellul J., Giannopoulos S., Magoufis G., Tsivgoulis G. (2022)
      The clinical manifestations of proximal (extracranial) internal carotid artery occlusions (pICAOs) may range from asymptomatic to acute, large, and devastating ischemic strokes. The etiology and pathophysiology of the ...
    • Difficult situations in anticoagulation after stroke: Between Scylla and Charybdis 

      Ntaios G., Lip G.Y.H. (2016)
      Purpose of review A significant proportion of stroke patients is treated with anticoagulants for secondary stroke prevention. Often, in such patients, stroke physicians are required to make difficult clinical decisions ...
    • Direct oral anticoagulant-vs Vitamin K antagonist-related nontraumatic intracerebral hemorrhage 

      Tsivgoulis G., Lioutas V.-A., Varelas P., Katsanos A.H., Goyal N., Mikulik R., Barlinn K., Krogias C., Sharma V.K., Vadikolias K., Dardiotis E., Karapanayiotides T., Pappa A., Zompola C., Triantafyllou S., Kargiotis O., Ioakeimidis M., Giannopoulos S., Kerro A., Tsantes A., Mehta C., Jones M., Schroeder C., Norton C., Bonakis A., Chang J., Alexandrov A.W., Mitsias P., Alexandrov A.V. (2017)
      Objective: To compare the neuroimaging profile and clinical outcomes among patients with intracerebral hemorrhage (ICH) related to use of vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs) for nonvalvular ...
    • Early recurrence and major bleeding in patients with acute ischemic stroke and atrial fibrillation treated with Non-Vitamin-K oral anticoagulants (RAF-NOACs) Study 

      Paciaroni M., Agnelli G., Falocci N., Tsivgoulis G., Vadikolias K., Liantinioti C., Chondrogianni M., Bovi P., Carletti M., Cappellari M., Zedde M., Ntaios G., Karagkiozi E., Athanasakis G., Makaritsis K., Silvestrelli G., Lanari A., Ciccone A., Putaala J., Tomppo L., Tatlisumak T., Abdul-Rahim A.H., Lees K.R., Alberti A., Venti M., Acciarresi M., D'Amore C., Becattini C., Mosconi M.G., Cimini L.A., Soloperto R., Masotti L., Vannucchi V., Lorenzini G., Tassi R., Guideri F., Acampa M., Martini G., Sohn S.-I., Marcheselli S., Mumoli N., De Lodovici M.L., Bono G., Furie K.L., Tadi P., Yaghi S., Toni D., Letteri F., Tassinari T., Kargiotis O., Lotti E.M., Flomin Y., Mancuso M., Maccarrone M., Giannini N., Bandini F., Pezzini A., Poli L., Padovani A., Scoditti U., Denti L., Consoli D., Galati F., Sacco S., Carolei A., Tiseo C., Gourbali V., Orlandi G., Giuntini M., Chiti A., Giorli E., Gialdini G., Corea F., Ageno W., Bellesini M., Colombo G., Monaco S., Baronello M.M., Karapanayiotides T., Caso V. (2017)
      Background--The optimal timing to administer non-vitamin K oral anticoagulants (NOACs) in patients with acute ischemic stroke and atrial fibrillation is unclear. This prospective observational multicenter study evaluated ...
    • Early recurrence in paroxysmal versus sustained atrial fibrillation in patients with acute ischaemic stroke 

      Paciaroni M., Angelini F., Agnelli G., Tsivgoulis G., Furie K.L., Tadi P., Becattini C., Falocci N., Zedde M., Abdul-Rahim A.H., Lees K.R., Alberti A., Venti M., Acciarresi M., Altavilla R., D’Amore C., Mosconi M.G., Cimini L.A., Bovi P., Carletti M., Rigatelli A., Cappellari M., Putaala J., Tomppo L., Tatlisumak T., Bandini F., Marcheselli S., Pezzini A., Poli L., Padovani A., Masotti L., Vannucchi V., Sohn S.-I., Lorenzini G., Tassi R., Guideri F., Acampa M., Martini G., Ntaios G., Karagkiozi E., Athanasakis G., Makaritsis K., Vadikolias K., Liantinioti C., Chondrogianni M., Mumoli N., Consoli D., Galati F., Sacco S., Carolei A., Tiseo C., Corea F., Ageno W., Bellesini M., Silvestrelli G., Ciccone A., Scoditti U., Denti L., Mancuso M., Maccarrone M., Orlandi G., Giannini N., Gialdini G., Tassinari T., Lodovici M.L.D., Bono G., Rueckert C., Baldi A., Toni D., Letteri F., Giuntini M., Lotti E.M., Flomin Y., Pieroni A., Kargiotis O., Karapanayiotides T., Monaco S., Baronello M.M., Csiba L., Szabó L., Chiti A., Giorli E., Sette M.D., Imberti D., Zabzuni D., Doronin B., Volodina V., Michel Pd-Mer P., Vanacker P., Barlinn K., Pallesen L.P., Kepplinger J., Deleu D., Melikyan G., Ibrahim F., Akhtar N., Gourbali V., Yaghi S., Caso V. (2019)
      Background: The relationship between different patterns of atrial fibrillation and early recurrence after an acute ischaemic stroke is unclear. Purpose: In a prospective cohort study, we evaluated the rates of early ischaemic ...
    • Early versus Late initiation of direct oral Anticoagulants in post-ischaemic stroke patients with atrial fibrillatioN (ELAN): Protocol for an international, multicentre, randomised-controlled, two-arm, open, assessor-blinded trial 

      Fischer U., Trelle S., Branca M., Salanti G., Paciaroni M., Ferrari C., Abend S., Beyeler S., Strbian D., Thomalla G., Ntaios G., Bonati L.H., Michel P., Nedeltchev K., Gattringer T., Sandset E.C., Kelly P., Lemmens R., Koga M., Sylaja P.N., de Sousa D.A., Bornstein N.M., Gdovinova Z., Seiffge D.J., Gralla J., Horvath T., Dawson J. (2022)
      Rationale: Direct oral anticoagulants (DOAC) are highly effective in preventing ischaemic strokes in people with atrial fibrillation (AF). However, it is unclear how soon they should be started after acute ischaemic stroke ...
    • Editorial: Current Challenges in Cardioembolic Stroke 

      Fuentes B., Ntaios G., Putaala J. (2021)
      [No abstract available]
    • The effect of carotid revascularization on the ophthalmic artery flow: Systematic review and meta-analysis 

      Nana P., Spanos K., Antoniou G., Kouvelos G., Vasileiou V., Tsironi E., Giannoukas A. (2021)
      Introduction: High-grade internal carotid stenosis results in impaired flow dynamics in the ocular circulation that may lead to a rare clinical entity; ophthalmic ischemic syndrome (OIS). The aim of this study was to ...
    • Effect of Ranolazine in Preventing Postoperative Atrial Fibrillation in Patients Undergoing Coronary Revascularization Surgery 

      Tagarakis, G. I.; Aidonidis, I.; Daskalopoulou, S. S.; Simopoulos, V.; Liouras, V.; Daskalopoulos, M. E.; Parisis, C.; Papageorgiou, K.; Skoularingis, I.; Triposkiadis, F.; Molyvdas, P. A.; Tsilimingas, N. B. (2013)
      Background/Objective: Ranolazine is a new anti-ischemic agent approved for chronic angina with additional electrophysiologic properties. The purpose of the present trial was to investigate its effect in preventing postoperative ...