Parcourir par sujet "autoimmune disease"

Anti-Ro52 antibody is highly prevalent and a marker of better prognosis in patients with ovarian cancer

Bogdanos D.P., Gkoutzourelas A., Papadopoulos V., Liaskos C., Patrikiou E., Tsigalou C., Saratziotis A., Hajiioannou J., Scheper T., Meyer W., Sakkas L.I., Papandreou C. (2021)

Background and Aims: Anti-Ro52 antibody (Ab) reactivity is highly prevalent in autoimmune rheumatic diseases (ARDs), mainly Sjögren's syndrome (SjS) and systemic lupus erythematosus (SLE), but also in other inflammatory ...

Antibody titers after a third dose of the SARS-CoV-2 BNT162b2 vaccine in immunocompromised adults in Greece: Is a fourth dose necessary?

Kontopoulou K., Nakas C.T., Belai C., Papazisis G. (2022)

Real-world data suggest that protection against COVID-19 declines a few months after vaccination, particularly in the elderly and immunocompromised individuals. Our study aimed to analyze the humoral response induced by a ...

Antimitochondrial antibodies of immunoglobulin G3 subclass are associated with a more severe disease course in primary biliary cirrhosis

Rigopoulou, E. I.; Davies, E. T.; Bogdanos, D. P.; Liaskos, C.; Mytilinaiou, M.; Koukoulis, G. K.; Dalekos, G. N.; Vergani, D. (2007)

Background/Aims: Primary biliary cirrhosis (PBC) is characterised by the presence of immunoglobulin (Ig) G antimitochondrial antibodies (AMA), which are routinely detected by indirect immunofluorescence (IFL) using composite ...

Arthritis and Myositis in a Patient Treated with Programmed Cell Death-1 (PD-1) Inhibitor Pembrolizumab for Lung Cancer

Pagkopoulou E., Simopoulou T., Maragkouli E., Perifanou-Sotiri S., Kotsakis A., Bogdanos D.P. (2020)

Immune checkpoint inhibitors (ICIs) are a new class of drug that have demonstrated efficacy across many cancer types. Because of their nature and mode of action, ICIs unleash immune activation raising concerns as to whether ...

Autoantibodies and SARS-CoV2 infection: The spectrum from association to clinical implication: Report of the 15th Dresden Symposium on Autoantibodies

Damoiseaux J., Dotan A., Fritzler M.J., Bogdanos D.P., Meroni P.L., Roggenbuck D., Goldman M., Landegren N., Bastard P., Shoenfeld Y., Conrad K. (2022)

The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal relation between these two entities with molecular mimicry, hyperstimulation and dysregulation ...

The autoimmunity–oral microbiome connection

Nikitakis N.G., Papaioannou W., Sakkas L.I., Kousvelari E. (2017)

To date, there is a major effort in deciphering the role of complex microbial communities, especially the oral and gut microbiomes, in the pathogenesis of various diseases. Increasing evidence indicates a key role for the ...

Black holes and high levels of neurofilaments in glial fibrillary acidic protein – astrocytopathy: a case report

Papa A., Tzartos J.S., Sakoutis G., Dardiotis E., Alexiou E., Breza M., Velonakis G., Papamichalis P., Mpampalis D., Komnos A., Karagiorgou A., Papakonstantinou A., Kilidireas C., Hadjigeorgiou G.M. (2020)

Background and purpose: Glial fibrillary acidic protein (GFAP) is an intracellular protein of the astrocytic cytoskeleton. Recently, autoantibodies to GFAP detected by cell-based assay in cerebrospinal fluid (CSF) or serum ...

Canine pancytopenia in the Mediterranean - Authors' reply

Frezoulis P.S., Angelidou E., Karnezi D., Oikonomidis I.L., Kritsepi-Konstantinou M., Kasabalis D., Mylonakis M.E. (2018)

[No abstract available]

A case of membranous nephropathy associated with Sjögren syndrome, polymyositis and autoimmune hepatitis

Stefanidis, I.; Giannopoulou, M.; Liakopoulos, V.; Dovas, S.; Karasavvidou, F.; Zachou, K.; Koukoulis, G. K.; Dalekos, G. N. (2008)

Sjögren syndrome (SS) is a chronic systemic autoimmune disease characterized by lymphocytic infiltration of exocrine glands, especially lacrimal and salivary. The immunologic process which occurs in this syndrome is B cell ...

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy revisited: Genotype-phenotype correlations of all published cases

Xiromerisiou G., Marogianni C., Dadouli K., Zompola C., Georgouli D., Provatas A., Theodorou A., Zervas P., Nikolaidou C., Stergiou S., Ntellas P., Sokratous M., Stathis P., Paraskevas G.P., Bonakis A., Voumvourakis K., Hadjichristodoulou C., Hadjigeorgiou G.M., Tsivgoulis G. (2020)

Objective The aim of this study was to evaluate the correlation between the various NOTCH3 mutations and their clinical and genetic profile, along with the presentation of a novel mutation in a patient.MethodsHere, we ...

The challenges of primary biliary cholangitis: What is new and what needs to be done

Terziroli Beretta-Piccoli B., Mieli-Vergani G., Vergani D., Vierling J.M., Adams D., Alpini G., Banales J.M., Beuers U., Björnsson E., Bowlus C., Carbone M., Chazouillères O., Dalekos G., De Gottardi A., Harada K., Hirschfield G., Invernizzi P., Jones D., Krawitt E., Lanzavecchia A., Lian Z.-X., Ma X., Manns M., Mavilio D., Quigley E.M., Sallusto F., Shimoda S., Strazzabosco M., Swain M., Tanaka A., Trauner M., Tsuneyama K., Zigmond E., Gershwin M.E. (2019)

Primary Biliary Cholangitis (PBC) is an uncommon, chronic, cholangiopathy of autoimmune origin and unknown etiology characterized by positive anti-mitochondrial autoantibodies (AMA), female preponderance and progression ...

Cheminformatics-aided discovery of small-molecule Protein-Protein Interaction (PPI) dual inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL)

Melagraki G., Ntougkos E., Rinotas V., Papaneophytou C., Leonis G., Mavromoustakos T., Kontopidis G., Douni E., Afantitis A., Kollias G. (2017)

We present an in silico drug discovery pipeline developed and applied for the identification and virtual screening of small-molecule Protein-Protein Interaction (PPI) compounds that act as dual inhibitors of TNF and RANKL ...

Clozapine associated with autoimmune reaction, fever and low level cardiotoxicity - a case report

Gerasimou C., Vitali G.P., Vavougios G.D., Papageorgiou C., Douzenis A., Kokoris S.I., Liappas I., Rizos E. (2017)

Background: Clozapine is a second-generation antipsychotic drug used in treatment-resistant schizophrenia. Fever induced by clozapine is a rather frequent side-effect which usually occurs in the first 4 weeks of treatment. ...

COVID-19 as an infectome paradigm of autoimmunity

Dotan A., Mahroum N., Bogdanos D.P., Shoenfeld Y. (2022)

[No abstract available]

COVID-19 immunopathology and the central nervous system: Implication for multiple sclerosis and other autoimmune diseases with associated demyelination

Boziki M.K., Mentis A.-F.A., Shumilina M., Makshakov G., Evdoshenko E., Grigoriadis N. (2020)

In the frame of the coronavirus disease 2019 (COVID-19) pandemic, recent reports on SARS-CoV-2 potential neuroinvasion placed neurologists on increased alertness in order to assess early neurological manifestations and ...

Decreased serum DNase1-activity in patients with autoimmune liver diseases

Gatselis N.K., Vakrakou A.G., Zachou K., Androutsakos T., Azariadis K., Hatzis G., Manoussakis M.N., Dalekos G.N. (2017)

Deoxyribonuclease1 (DNase1) is involved in chromatin degradation of apoptotic cells. Its deficiency results in accumulation of self-DNA, which in turn may induce inflammation and autoimmunity. We assessed for the first ...

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis

Liu, J. Z.; Hov, J. R.; Folseraas, T.; Ellinghaus, E.; Rushbrook, S. M.; Doncheva, N. T.; Andreassen, O. A.; Weersma, R. K.; Weismüller, T. J.; Eksteen, B.; Invernizzi, P.; Hirschfield, G. M.; Gotthardt, D. N.; Pares, A.; Ellinghaus, D.; Shah, T.; Juran, B. D.; Milkiewicz, P.; Rust, C.; Schramm, C.; Muler, T.; Srivastava, B.; Dalekos, G.; Nöthen, M. M.; Herms, S.; Winkelmann, J.; Mitrovic, M.; Braun, F.; Ponsioen, C. Y.; Croucher, P. J. P.; Sterneck, M.; Teufel, A.; Andrew, L. Mason; Saarela, J.; Leppa, V.; Dorfman, R.; Alvaro, D.; Floreani, A.; Onengut-Gumuscu, S.; Rich, S. S.; Thompson, W. K.; Schork, A. J.; Næss, S.; Thomsen, I.; Mayr, G.; König, I. R.; Hveem, K.; Cleynen, I.; Gutierrez-Achury, J.; Ricaño-Ponce, I.; Van Heel, D.; Björnsson, E.; Sandford, R. N.; Durie, P. R.; Melum, E.; Vatn, M. H.; Silverberg, M. S.; Duerr, R. H.; Padyukov, L.; Brand, S.; Sans, M.; Annese, V.; Achkar, J. P.; Boberg, K. M.; Marschall, H. U.; Chazouillères, O.; Bowlus, C. L.; Wijmenga, C.; Schrumpf, E.; Vermeire, S.; Albrecht, M.; Rioux, J. D.; Alexander, G.; Bergquist, A.; Cho, J.; Schreiber, S.; Manns, M. P.; Färkkilä, M.; Dale, A. M.; Chapman, R. W.; Konstantinos, N. Lazaridis; Franke, A.; Anderson, C. A.; Karlsen, T. H. (2013)

Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading to fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation. We compared 3,789 PSC cases of ...

Effects of Exercise and Physical Activity Levels on Vaccination Efficacy: A Systematic Review and Meta-Analysis

Dinas P.C., Koutedakis Y., Ioannou L.G., Metsios G., Kitas G.D. (2022)

Objective: We examined whether different intensities of exercise and/or physical activity (PA) levels affected and/or associated with vaccination efficacy. Methods: A systematic review and meta-analysis was conducted and ...

Enterococcus gallinarum as a component of the Autoinfectome: The gut-liverautoimmune rheumatic disease axis is alive and kicking

Bogdanos D.P., Sakkas L.I. (2018)

[No abstract available]

Exploring the potential of mucin 13 (MUC13) as a biomarker for carcinomas and other diseases

Filippou P.S., Ren A.H., Korbakis D., Dimitrakopoulos L., Soosaipillai A., Barak V., Frenkel S., Pe'Er J., Lotem M., Merims S., Molina R., Blasutig I., Bogdanos D.P., Diamandis E.P. (2018)

Mucin 13 (MUC13) is a cell surface glycoprotein aberrantly expressed in a variety of epithelial carcinomas. Thus far, the role of MUC13 in various diseases remains elusive. To the best of our knowledge, this is the first ...