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Urate crystals induce NLRP3 inflammasome-dependent IL-1 beta secretion and proliferation in isolated primary human T-cells

Eleftheriadis, T.; Pissas, G.; Antoniadi, G.; Makri, P.; Liakopoulos, V.; Stefanidis, I. (2015)

Background: Urate through NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome-dependent caspase-1 activation stimulates macrophages to secrete inteleukin-1 beta (IL-1 beta). Urate also enhances adaptive ...
Uric acid induces caspase-1 activation, IL-1 beta secretion and P2X7 receptor dependent proliferation in primary human lymphocytes

Eleftheriadis, T.; Pissas, G.; Karioti, A.; Antoniadi, G.; Golfinopoulos, S.; Liakopoulos, V.; Mamara, A.; Speletas, M. M.; Koukoulis, G.; Stefanidis, I. (2013)

Background: Urate through Nacht Domain, Leucine-Rich Repeat, and pyrin domain-containing protein 3 (NALP3) dependent caspase-1 activation stimulates macrophages to secrete inteleukin-1 beta (IL-1 beta). Purinergic receptor ...