Listar por tema "metabolism"

3rd European Biobed Workshop

de Wilde, T.; Capri, E.; Husby, J.; Del Castillo, M. P.; Karpouzas, D.; Nilsson, E.; Spliid, N. H. (2011)

99mTc-sestamibi uptake in rat skeletal muscle and heart: Physiological determinants and correlations

Arsos, G.; Kyparos, A.; Moralidis, E.; Kyparos, D.; Georga, S.; Sotiriadou, S.; Matziari, C.; Karakatsanis, C. (2009)

The lipophilic cationic radiotracer 99mTc-sestamibi, known to be concentrated within mitochondria, is widely used for myocardial perfusion and to a lesser extent for muscle metabolism imaging. However, the exact distribution ...

Achilles, a new family of transcriptionally active retrotransposons from the olive fruit fly, with y chromosome preferential distribution

Tsoumani K.T., Drosopoulou E., Bourtzis K., Gariou-Papalexiou A., Mavragani-Tsipidou P., Zacharopoulou A., Mathiopoulos K.D. (2015)

Sex chromosomes have many unusual features relative to autosomes. The in depth exploration of their structure will improve our understanding of their origin and divergence (degeneration) as well as the evolution of genetic ...

Acquisition of optimal TFH cell function is defined by specific molecular, positional, and TCR dynamic signatures

Padhan K., Moysi E., Noto A., Chassiakos A., Ghneim K., Perra M.M., Shah S., Papaioannou V., Fabozzi G., Ambrozak D.R., Poultsidi A., Ioannou M., Fenwick C., Darko S., Douek D.C., Sekaly R.-P., Pantaleo G., Koup R.A., Petrovas C. (2021)

The development of follicular helper CD4 T (TFH) cells is a dynamic process resulting in a heterogenous pool of TFH subsets. However, the cellular and molecular determinants of this heterogeneity and the possible mechanistic ...

Activation of FADD-Dependent neuronal death pathways as a predictor of pathogenicity for LRRK2 mutations

Melachroinou K., Leandrou E., Valkimadi P.-E., Memou A., Hadjigeorgiou G., Stefanis L., Rideout H.J. (2016)

Background Despite the plethora of sequence variants in LRRK2, only a few clearly segregate with PD. Even within this group of pathogenic mutations, the phenotypic profile can differ widely. Objective We examined multiple ...

Activation of general control nonderepressible 2 kinase protects human glomerular endothelial cells from harmful high-glucose-induced molecular pathways

Eleftheriadis T., Tsogka K., Pissas G., Antoniadi G., Liakopoulos V., Stefanidis I. (2016)

Purpose: Considering the referred beneficial effects of protein restriction on diabetic nephropathy (DN) and the role of renal endothelium in its pathogenesis, we evaluated the effect of general control nonderepressible 2 ...

Activation of general control nonderepressible-2 kinase ameliorates glucotoxicity in human peritoneal mesothelial cells, preserves their integrity, and prevents mesothelial to mesenchymal transition

Eleftheriadis T., Pissas G., Antoniadi G., Nikolaou E., Golfinopoulos S., Liakopoulos V., Stefanidis I. (2019)

Along with infections, ultrafiltration failure due to the toxicity of glucose-containing peritoneal dialysis (PD) solutions is the Achilles’ heel of PD method. Triggered by the protective effect of general control ...

The activity of three glycosidases (β-Ν-acetyloglucosaminidase, α-mannosidase, and β-galactosidase) in the follicular fluid and in the maturation medium affects bovine oocyte maturation

Dovolou E., Samartzi F., Perreau C., Krania F., Cordova A., Vainas E., Amiridis G.S., Mermillod P., Tsiligianni T. (2016)

We studied the role of follicular fluid's (FF) glycosidase (α-mannosidase [α-ΜΑΝ], β-Ν-acetyloglucosaminidase [NAGASE], β-galactosidase [β-GAL]) activity during IVM of bovine oocytes. Oocytes were allocated into two groups ...

Administration of exercise-conditioned plasma alters muscle catalase kinetics in rat: An argument for in vivo-like Km instead of in vitro-like Vmax

Veskoukis A.S., Paschalis V., Kyparos A., Nikolaidis M.G. (2018)

Maximal velocity (Vmax) is a well established biomarker for the assessment of tissue redox status. There is scarce evidence, though, that it does not probably reflect sufficiently in vivo tissue redox profile. Instead, the ...

Advances in understanding the mitogenic, metabolic, and cell death signaling in teleost development: the case of greater amberjack (Seriola dumerili, Risso 1810)

Panteli N., Demertzioglou M., Feidantsis K., Karapanagiotis S., Tsele N., Tsakoniti K., Gkagkavouzis K., Mylonas C.C., Kormas K.A., Mente E., Antonopoulou E. (2022)

Cell growth and differentiation signals of insulin-like growth factor-1 (IGF-1), a key regulator in embryonic and postnatal development, are mediated through the IGF-1 receptor (IGF-1R), which activates several downstream ...

Aerobic, resistance and combined training and detraining on body composition, muscle strength, lipid profile and inflammation in coronary artery disease patients

Theodorou A.A., Panayiotou G., Volaklis K.A., Douda H.T., Paschalis V., Nikolaidis M.G., Smilios I., Toubekis A., Kyprianou D., Papadopoulos I., Tokmakidis S.P. (2016)

Fifty-six elderly individuals diagnosed with coronary artery disease participated in the study and were divided into four groups: an aerobic exercise group, a resistance exercise group, a combined (aerobic + resistance) ...

Affinity crystallography reveals the bioactive compounds of industrial juicing byproducts of Punica granatum for glycogen phosphorylase

Stravodimos G.A., Kantsadi A.L., Apostolou A., Kyriakis E., Kafaski-Kanelli V.-N., Solovou T., Gatzona P., Liggri P.G.V., Theofanous S., Gorgogietas V.A., Kissa A., Psachoula C., Lemonakis A., Chatzileontiadou D.S.M., Psarra A.-M.G., Skamnaki V.T., Haroutounian S.A., Leonidas D.E. (2018)

Background: Glycogen phosphorylase (GP) is a pharmaceutical target for the discovery of new antihyperglycaemic agents. Punica granatum is a well-known plant for its potent antioxidant and antimicrobial activities but so ...

Age, Body Mass Index, and Daytime and Nocturnal Hypoxia as Predictors of Hypertension in Patients With Obstructive Sleep Apnea

Natsios G., Pastaka C., Vavougios G., Zarogiannis S.G., Tsolaki V., Dimoulis A., Seitanidis G., Gourgoulianis K.I. (2016)

A growing body of evidence links obstructive sleep apnea (OSA) with hypertension. The authors performed a retrospective cohort study using the University Hospital of Larissa Sleep Apnea Database (1501 patients) to determine ...

Age, human performance, and physical employment standards

Kenny G.P., Groeller H., McGinn R., Flouris A.D. (2016)

The proportion of older workers has increased substantially in recent years, with over 25% of the Canadian labour force aged ≥55 years. Along with chronological age comes age-related declines in functional capacity associated ...

Alanyl-glutamine restores tight junction organization after disruption by a conventional peritoneal dialysis fluid

Bartosova M., Herzog R., Ridinger D., Levai E., Jenei H., Zhang C., González Mateo G.T., Marinovic I., Hackert T., Bestvater F., Hausmann M., Cabrera M.L., Kratochwill K., Zarogiannis S.G., Schmitt C.P. (2020)

Understanding and targeting the molecular basis of peritoneal solute and protein transport is essential to improve peritoneal dialysis (PD) efficacy and patient outcome. Supplementation of PD fluids (PDF) with alanyl-glutamine ...

Allopurinol protects human glomerular endothelial cells from high glucose-induced reactive oxygen species generation, p53 overexpression and endothelial dysfunction

Eleftheriadis T., Pissas G., Antoniadi G., Liakopoulos V., Stefanidis I. (2018)

Purpose: Mitochondrial reactive oxygen species (ROS) overproduction in capillary endothelial cells is a prerequisite for the development of diabetic nephropathy. Inhibition of xanthine oxidase, another ROS generator, ...

Alterations in xenobiotic-metabolizing enzyme activities across menstrual cycle in healthy volunteers

Asprodini E., Tsiokou V., Begas E., Kilindris T., Kouvaras E., Samara M., Messinis I. (2019)

The purpose of the study was to determine whether the in vivo activities of drug-metabolizing enzymes CYP1A2 and CYP2A6, xanthine oxidase (XO), and N-acetyltransferase-2 (NAT2) vary across the menstrual cycle. Forty-two ...

Altered activity of xenobiotic detoxifying enzymes at menopause – A cross-sectional study

Tsiokou V., Kilindris T., Begas E., Kouvaras E., Kouretas D., Asprodini E.K. (2020)

Xenobiotic metabolism at menopause is an under-investigated topic, albeit women spend one-third of their life in the postmenopausal period. The present study examined the effect of menopause on the in vivo activities of ...

Amino acid signatures in the HLA class II peptide-binding region associated with protection/susceptibility to the severe West Nile Virus disease

Sarri C.A., Papadopoulos G.E., Papa A., Tsakris A., Pervanidou D., Baka A., Politis C., Billinis C., Hadjichristodoulou C., Mamuris Z. (2018)

The MHC class II region in humans is highly polymorphic. Each MHC molecule is formed by an α and a β chain, produced by different genes, creating an antigen-binding groove. In the groove there are several pockets into which ...

Annonacin promotes selective cancer cell death via NKA-dependent and SERCA-dependent pathways

Yiallouris A., Patrikios I., Johnson E.O., Sereti E., Dimas K., De Ford C., Fedosova N.U., Graier W.F., Sokratous K., Kyriakou K., Stephanou A. (2018)

In the healthcare sector, phytocompounds are known to be beneficial by contributing or alleviating a variety of diseases. Studies have demonstrated the progressive effects of phytocompounds on immune-related diseases and ...