Listar por tema "MgcRacGAP"

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MgcRacGAP interacts with HIF-1 alpha and regulates its transcriptional activity

Lyberopoulou, A.; Venieris, E.; Mylonis, I.; Chachami, G.; Pappas, I.; Simos, G.; Bonanou, S.; Georgatsou, E. (2007)

HIF-1 alpha is the inducible subunit of the dimeric transcription factor HIF-1 (Hypoxia Inducible Factor 1). It is induced by hypoxia and hypoxia-mimetics in most cell types, as well as non-hypoxic signals such as growth ...
MgcRacGAP, a cytoskeleton regulator, inhibits HIF-1 transcriptional activity by blocking its dimerization

Lyberopoulou, A.; Mylonis, I.; Papachristos, G.; Sagris, D.; Kalousi, A.; Befani, C.; Liakos, P.; Simos, G.; Georgatsou, E. (2013)

Hypoxia inducible factor-1 (HIF-1), a dimeric transcription factor of the bHLH-PAS family, is comprised of HIF-1 alpha, which is inducible by hypoxia and ARNT or HIF-1 beta, which is constitutively expressed. HIF-1 is ...