Browsing by Subject "pathology"

A 72-Year-Old Woman With Multiple Pulmonary Nodules and a History of Malignancy

Perlepe G., Karetsi E., Papamichali R., Papadopoulos D., Chevas A., Gourgoulianis K.I. (2021)

A 72-year-old woman, nonsmoker, presented with approximately 2 months of nonproductive cough. The cough was initially intermittent, occurred more regularly during bedtime, but gradually became more frequent throughout the ...

ACOS syndrome: Single disease entity or not? Could exhaled nitric oxide be a useful biomarker for the differentiation of ACOS, asthma and COPD?

Karampitsakos T., Gourgoulianis K.I. (2016)

Asthma and chronic obstructive pulmonary disease (COPD) represent two major public health problems. However, there is a significant proportion of patients with a mixed asthma-COPD phenotype. This condition is defined as ...

Activation of FADD-Dependent neuronal death pathways as a predictor of pathogenicity for LRRK2 mutations

Melachroinou K., Leandrou E., Valkimadi P.-E., Memou A., Hadjigeorgiou G., Stefanis L., Rideout H.J. (2016)

Background Despite the plethora of sequence variants in LRRK2, only a few clearly segregate with PD. Even within this group of pathogenic mutations, the phenotypic profile can differ widely. Objective We examined multiple ...

Activation of general control nonderepressible 2 kinase protects human glomerular endothelial cells from harmful high-glucose-induced molecular pathways

Eleftheriadis T., Tsogka K., Pissas G., Antoniadi G., Liakopoulos V., Stefanidis I. (2016)

Purpose: Considering the referred beneficial effects of protein restriction on diabetic nephropathy (DN) and the role of renal endothelium in its pathogenesis, we evaluated the effect of general control nonderepressible 2 ...

Addressing the post-irradiation hypothalamic-pituitary endocrine abnormalities of brain tumors in pediatric patients

Velentza L., Tolia M., Christakou C., Nikolaou M., Zerdes I.-N., Tsoukalas N., Hajiioannou J., Tsanadis K., Rigas G., Mitsis M., Theodorou K., Pistevou-Gombaki K., Tsekeris P., Kyrgias G. (2017)

Purpose: Hypothalamic-pituitary axis is susceptible to radiotherapy, causing endocrine disorders to childhood cancer survivors. We conducted a systematic review in order to assess the radiation-induced toxicity that leads ...

Adenoid cystic carcinoma stage Ib1 treated with radical surgery displaying human papilloma virus 33 (HPV 33): immunoelectron microscopy and review

Daponte, A.; Grayson, W.; Moisuc, D.; Ebrahim, S.; Guidozzi, F. (2003)

BACKGROUND: The presence of human papilloma virus (HPV) 33 and possible myoepithelial differentiation in an adenoid cystic carcinoma of the cervix (ACC) Ib1 and the clinical outcome are reported. CASE: The case is an ACC, ...

Advanced Non-linear Mathematical Model for the Prediction of the Activity of a Putative Anticancer Agent in Human-to-mouse Cancer Xenografts

Liliopoulos S.G., Stavrakakis G.S., Dimas K.S. (2020)

Background/Aim: Mathematical models have long been considered as important tools in cancer biology and therapy. Herein, we present an advanced non-linear mathematical model that can predict accurately the effect of an ...

AJCC-8 TNM Staging System for Gastric Cancer. Is There a Scope for Improvement?: (Invited brief commentary on a paper entitled: Proposed modification of the 8th edition of the AJCC staging system for gastric cancer)

Tsoukalas N., Tsapakidis K., Kamposioras K. (2020)

[No abstract available]

aMAP risk score predicts hepatocellular carcinoma development in patients with chronic hepatitis

Fan R., Papatheodoridis G., Sun J., Innes H., Toyoda H., Xie Q., Mo S., Sypsa V., Guha I.N., Kumada T., Niu J., Dalekos G., Yasuda S., Barnes E., Lian J., Suri V., Idilman R., Barclay S.T., Dou X., Berg T., Hayes P.C., Flaherty J.F., Zhou Y., Zhang Z., Buti M., Hutchinson S.J., Guo Y., Calleja J.L., Lin L., Zhao L., Chen Y., Janssen H.L.A., Zhu C., Shi L., Tang X., Gaggar A., Wei L., Jia J., Irving W.L., Johnson P.J., Lampertico P., Hou J. (2020)

Background & Aims: Hepatocellular carcinoma (HCC) is the leading cause of death in patients with chronic hepatitis. In this international collaboration, we sought to develop a global universal HCC risk score to predict the ...

Anti-C1q autoantibodies are frequently detected in patients with systemic sclerosis associated with pulmonary fibrosis

Liaskos C., Rentouli S., Simopoulou T., Gkoutzourelas A., Norman G.L., Brotis A., Alexiou I., Katsiari C., Bogdanos D.P., Sakkas L.I. (2019)

Background: Anti-C1q autoantibodies (autoAbs) are associated with systemic lupus erythematosus (SLE), but their presence in other rheumatic diseases has not been adequately investigated. Objectives: We aimed to assess ...

Anti-invasive effects of CXCR4 and FAK inhibitors in non-small cell lung carcinomas with mutually inactivated p53 and PTEN tumor suppressors

Dragoj M., Bankovic J., Sereti E., Stojanov S.J., Dimas K., Pesic M., Stankovic T. (2017)

Non-small cell lung carcinoma (NSCLC) is the most common type of lung cancer. At the time of diagnosis, a large percentage of NSCLC patients have already developed metastasis, responsible for extremely high mortality rates. ...

Anti-MCV antibodies predict radiographic progression in Greek patients with very early (<3 months duration) rheumatoid arthritis

Barouta G., Katsiari C.G., Alexiou I., Liaskos C., Varna A., Bogdanos D.P., Germenis A.E., Sakkas L.I. (2017)

This study aimed to assess the diagnostic and prognostic value of anti-mutated citrullinated vimentin (MCV) antibodies in very early rheumatoid arthritis (VERA) and in established rheumatoid arthritis (RA). Seventy-one ...

Anti-Ro60 Seropositivity Determines Anti-Ro52 Epitope Mapping in Patients With Systemic Sclerosis

Gkoutzourelas A., Liaskos C., Mytilinaiou M.G., Simopoulou T., Katsiari C., Tsirogianni A., Daoussis D., Scheper T., Meyer W., Bogdanos D.P., Sakkas L.I. (2018)

Epitope mapping of anti-Ro52 antibodies (Abs) has been extensively studied in patients with Sjögren's syndrome (SjS) and systemic lupus erythematosus (SLE). Comprehensive epitope mapping in systemic sclerosis (SSc), where ...

Anticancer and apoptosis-inducing effects of quercetin in vitro and in vivo

Hashemzaei M., Far A.D., Yari A., Heravi R.E., Tabrizian K., Taghdisi S.M., Sadegh S.E., Tsarouhas K., Kouretas D., Tzanakakis G., Nikitovic D., Anisimov N.Y., Spandidos D.A., Tsatsakis A.M., Rezaee R. (2017)

The present study focused on the elucidation of the putative anticancer potential of quercetin. The anticancer activity of quercetin at 10, 20, 40, 80 and 120 μM was assessed in vitro by MMT assay in 9 tumor cell lines ...

Anticarcinogenic activity of polyphenolic extracts from grape stems against breast, colon, renal and thyroid cancer cells

Sahpazidou, D.; Geromichalos, G. D.; Stagos, D.; Apostolou, A.; Haroutounian, S. A.; Tsatsakis, A. M.; Tzanakakis, G. N.; Hayes, A. W.; Kouretas, D. (2014)

A major part of the wineries' wastes is composed of grape stems which are discarded mainly in open fields and cause environmental problems due mainly to their high polyphenolic content. The grape stem extracts' use as a ...

Apremilast increases IL-10-producing regulatory B cells and decreases proinflammatory T cells and innate cells in psoriatic arthritis and psoriasis

Mavropoulos A., Zafiriou E., Simopoulou T., Brotis A.G., Liaskos C., Roussaki-Schulze A., Katsiari C.G., Bogdanos D.P., Sakkas L.I. (2019)

Objectives: Psoriatic arthritis (PsA) and psoriasis are immune-mediated inflammatory diseases sharing common immunological mechanisms. Regulatory B cells (Breg cells) producing IL-10 (B10 cells), a critical anti-inflammatory ...

Aquaculture systems and pathological problems of new species reared in fresh water in Greece [Χαρακτηριστικά εκτροφής και παθολογικά προβλήματα νέων ειδών εκτρεφόμενων ψαριών γλυκού νερού οτην Ελλάδα]

Ragias B., Athanassopoulou F. (2017)

Published data on growth and pathology of the fish species: Mugil cephalus (mullet) and Acipenser gueldestaedi (sturgeon), under intensive culture, is limited. In particular, data on dietary requirements is non-existing. ...

Artificial intelligence in small bowel capsule endoscopy - current status, challenges and future promise

Dray X., Iakovidis D., Houdeville C., Jover R., Diamantis D., Histace A., Koulaouzidis A. (2021)

Neural network-based solutions are under development to alleviate physicians from the tedious task of small-bowel capsule endoscopy reviewing. Computer-assisted detection is a critical step, aiming to reduce reading times ...

Ascending aortic intramural hematoma: current concepts

Nana P., Kouvelos G., Spanos K. (2022)

Purpose of review Type A intramural hematoma (TAIMH) is an acute aortic disease characterized by the presence of hematoma in the aortic media and involving the ascending aorta. Open repair seems to be the first treatment ...

Assessment of the efficacy and clinical utility of different circulating tumor cell (CTC) detection assays in patients with chemotherapy-naïve advanced or metastatic non-small cell lung cancer (NSCLC)

Papadaki M.A., Messaritakis I., Fiste O., Souglakos J., Politaki E., Kotsakis A., Georgoulias V., Mavroudis D., Agelaki S. (2021)

We herein investigated the detection frequency and clinical relevance of circulating tumor cells (CTCs) in chemotherapy-naïve stage IIIB/IV non-small cell lung cancer (NSCLC), by using the CellSearch and real-time CEACAM5mRNA ...