Browsing by Author "Rafail, S."
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Endothelin-1 Signaling Promotes Fibrosis In Vitro in a Bronchopulmonary Dysplasia Model by Activating the Extrinsic Coagulation Cascade
Kambas, K.; Chrysanthopoulou, A.; Kourtzelis, I.; Skordala, M.; Mitroulis, I.; Rafail, S.; Vradelis, S.; Sigalas, I.; Wu, Y. Q.; Speletas, M.; Kolios, G.; Ritis, K. (2011)Neonatal respiratory distress syndrome can progress to bronchopulmonary dysplasia (BPD), a serious pulmonary fibrotic disorder. Given the involvement of the extrinsic coagulation cascade in animal models of lung fibrosis, ... -
Leptin induces the expression of functional tissue factor in human neutrophils and peripheral blood mononuclear cells through JAK2-dependent mechanisms and TNF alpha involvement
Rafail, S.; Ritis, K.; Schaefer, K.; Kourtzelis, I.; Speletas, M.; Doumas, M.; Giaglis, S.; Kambas, K.; Konstantinides, S.; Kartalis, G. (2008)Introduction: Leptin is an adipocyte-derived cytokine primarily involved in the regulation of body weight and energy balance. In vivo studies suggest that leptin promotes platelet aggregation and thrombosis. Neutrophils ... -
MEFV alterations and population genetics analysis in a large cohort of Greek patients with familial Mediterranean fever
Giaglis, S.; Papadopoulos, V.; Kambas, K.; Doumas, M.; Tsironidou, V.; Rafail, S.; Kartalis, G.; Speletas, M.; Ritis, K. (2007)Familial Mediterranean fever (FMF) is a disease characterized by recurrent, self-limiting bouts of fever and serositis and caused by altered pyrin due to mutated MEFV gene. FMF is common in the Mediterranean Basin populations, ... -
Regulation of the autophagic machinery in human neutrophils
Mitroulis, I.; Kourtzelis, I.; Kambas, K.; Rafail, S.; Chrysanthopoulou, A.; Speletas, M.; Ritis, K. (2010)The induction of the autophagy machinery, a process for the catabolism of cytosolic proteins and organelles, constitutes a crucial mechanism in innate immunity. However, the involvement of autophagy in human neutrophils ...