Auflistung Nach Schlagwort "cell migration"

Alpha-actinin: A multidisciplinary protein with important role in B-cell driven autoimmunity

Kikonomou, K. G.; Zachou, K.; Dalekos, G. N. (2011)

Alpha-actinin (α-actinin) is a ubiquitous cytoskeletal protein, which belongs to the superfamily of filamentous actin (F-actin) crosslinking proteins. It is present in multiple subcellular regions of both muscle and ...

Anti-invasive effects of CXCR4 and FAK inhibitors in non-small cell lung carcinomas with mutually inactivated p53 and PTEN tumor suppressors

Dragoj M., Bankovic J., Sereti E., Stojanov S.J., Dimas K., Pesic M., Stankovic T. (2017)

Non-small cell lung carcinoma (NSCLC) is the most common type of lung cancer. At the time of diagnosis, a large percentage of NSCLC patients have already developed metastasis, responsible for extremely high mortality rates. ...

CD90/Thy-1, a cancer-associated cell surface signaling molecule

Sauzay C., Voutetakis K., Chatziioannou A.A., Chevet E., Avril T. (2019)

CD90 is a membrane GPI-anchored protein with one Ig V-type superfamily domain that was initially described in mouse T cells. Besides the specific expression pattern and functions of CD90 that were described in normal tissues ...

Cell and extracellular matrix interaction models in benign mesothelial and malignant pleural mesothelioma cells in 2D and 3D in-vitro

Jagirdar R.M., Papazoglou E.D., Pitaraki E., Kouliou O.A., Rouka E., Giannakou L., Giannopoulos S., Sinis S.I., Hatzoglou C., Gourgoulianis K.I., Zarogiannis S.G. (2021)

Malignant pleural mesothelioma (MPM) is an aggressive tumour that grows in the pleural cavity. MPM spheroids released in the pleural fluid can form new tumour foci. Cell–cell, cell–extracellular matrix (ECM) interactions ...

Cell migration leads to spatially distinct but clonally related airway cancer precursors

Pipinikas, C. P.; Kiropoulos, T. S.; Teixeira, V. H.; Brown, J. M.; Varanou, A.; Falzon, M.; Capitanio, A.; Bottoms, S. E.; Carrol, B.; Navani, N.; McCaughan, F.; George, J. P.; Giangreco, A.; Wright, N. A.; McDonald, S. A. C.; Graham, T. A.; Janes, S. M. (2014)

Background Squamous cell carcinoma of the lung is a common cancer with 95% mortality at 5 years. These cancers arise from preinvasive lesions, which have a natural history of development progressing through increasing ...

Complement: An inflammatory pathway fulfilling multiple roles at the interface of innate immunity and development

Mastellos, D.; Germenis, A. E.; Lambris, J. D. (2005)

Complement has been long perceived as an innate immune system that plays a pivotal role in the maintenance of host defense against infectious agents and the propagation of proinflammatory responses in the context of human ...

Crosstalk mechanisms between the WNT signaling pathway and long non-coding RNAs

Zarkou V., Galaras A., Giakountis A., Hatzis P. (2018)

The WNT/β-catenin signaling pathway controls a plethora of biological processes throughout animal development and adult life. Because of its fundamental role during animal lifespan, the WNT pathway is subject to strict ...

HIF-1α-derived cell-penetrating peptides inhibit ERK-dependent activation of HIF-1 and trigger apoptosis of cancer cells under hypoxia

Karagiota A., Kourti M., Simos G., Mylonis I. (2019)

Hypoxia is frequently encountered in the microenvironment of solid tumors. Hypoxia-inducible factors (HIFs), the main effectors of cell response to hypoxia, promote cancer cell survival and progression. HIF-1α, the ...

Hypoxia upregulates integrin gene expression in microvascular endothelial cells and promotes their migration and capillary-like tube formation

Befani C., Liakos P. (2017)

Tissue hypoxia affects gene expression through the hypoxia-inducible transcription factors, HIF-1 and HIF-2, in both physiological and pathological angiogenesis. Angiogenesis is a complex response of endothelial cells ...

HΜGB1/sRAGE levels differ significantly between transudates and exudates

Kotsiou O.S., Jagirdar R.M., Papazoglou E.D., Hatzoglou C., Gourgoulianis K.I., Zarogiannis S.G. (2021)

High mobility group box 1(HMGB1) protein operates as an alarmin with multiple roles in immunity and cell homeostasis. It is highly expressed in epithelial barrier sites and acts via the binding to the receptor for advanced ...

Influence of AQP1 on cell adhesion, migration, and tumor sphere formation in malignant pleural mesothelioma is substratum-and histological-type dependent

Jagirdar R.M., Apostolidou E., Molyvdas P.A., Gourgoulianis K.I., Hatzoglou C., Zarogiannis S.G. (2016)

Malignant pleural mesothelioma (MPM) is an aggressive cancer. MPM cells express aquaporin-1 (AQP1) that in other cancers has been shown to participate in the tumor metastasis processes. However, in MPM patients AQP1 ...

Istaroxime Inhibits Motility and Down-Regulates Orai1 Expression, SOCE and FAK Phosphorylation in Prostate Cancer Cells

Stagno M.J., Zacharopoulou N., Bochem J., Tsapara A., Pelzl L., Al-Maghout T., Kallergi G., Alkahtani S., Alevizopoulos K., Dimas K., Calogeropoulou T., Warmann S.W., Lang F., Schmid E., Stournaras C. (2017)

Background/Aims: Istaroxime is a validated inotropic Na + /K + ATPase inhibitor currently in development for the treatment of various cardiac conditions. Recent findings established that this steroidal drug exhibits potent ...

Marine bromophenol bis(2,3,6-tribromo-4, 5-dihydroxybenzyl)ether inhibits angiogenesis in human umbilical vein endothelial cells and reduces vasculogenic mimicry in human lung cancer a549 cells

Dong S., Chen Z., Wang L., Liu Y., Stagos D., Lin X., Liu M. (2021)

Angiogenesis, including the growth of new capillary blood vessels from existing ones and the malignant tumors cells formed vasculogenic mimicry, is quite important for the tumor metastasis. Anti-angiogenesis is one of the ...

Mechanisms involved in oxidative stress regulation

Kouretas, D.; Tsatsakis, A. M.; Domingo, J. L.; Wallace Hayes, A. (2013)

On the immunoregulatory role of statins in multiple sclerosis: the effects on Th17 cells

Ntolkeras G., Barba C., Mavropoulos A., Vasileiadis G.K., Dardiotis E., Sakkas L.I., Hadjigeorgiou G., Bogdanos D.P. (2019)

Statins, the cholesterol-lowering drugs, also possess immunomodulatory properties, affecting among others T cell activation and differentiation, antigen presentation, and regulatory T cell (Tregs) maintenance and ...

Persistent Activation of Innate Immunity in Patients with Primary Antibody Deficiencies

Tsinti G., Makris D., Germenis A.E., Speletas M. (2020)

Primary antibody deficiencies (PAD) represent a heterogeneous group of disorders, with common variable immunodeficiency being the most common with clinical significance. The main phenotypic defect resides in the inability ...

Pleural Effusion IL-33/sST2 Levels and Effects of Low and High IL-33/sST2 Levels on Human Mesothelial Cell Adhesion and Migration

Kotsiou O.S., Jagirdar R.M., Papazoglou E.D., Hatzoglou C., Gourgoulianis K.I., Zarogiannis S.G. (2019)

Interleukin 33 (IL-33) is an alarmin with multiple roles in immunity and cell homeostasis, highly expressed in barrier sites, acting via the suppression of tumorigenicity 2 receptor (ST2). Production of IL-33 and soluble ...