Auflistung nach Autor "Gkizis, P."
Anzeige der Dokumente 1-4 von 4
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N-substituted Pyrrole-based Scaffolds as Potential Anticancer and Antiviral Lead Structures
Pegklidou, K.; Papastavrou, N.; Gkizis, P.; Komiotis, D.; Balzarini, J.; Nicolaou, I. (2015)Undoubtedly, efficient cancer treatment has been a significant challenge for the scientific community over the last decades. Despite tremendous progress made towards this direction, there are still efforts needed to discover ... -
A novel and easy two-step, microwave-assisted method for the synthesis of halophenyl pyrrolo 2,3-b quinoxalines via their pyrrolo precursors. Evaluation of their bioactivity
Manta, S.; Gkaragkouni, D. N.; Kaffesaki, E.; Gkizis, P.; Hadjipavlou-Litina, D.; Pontiki, E.; Balzarini, J.; Dehaen, W.; Komiotis, D. (2014)A novel, two-step, facile route for the synthesis of pyrrolo[2,3-b]quinoxalines via 2,3-dioxopyrroles, enhanced by microwave irradiation, is presented. The newly synthesized 2,3-dioxo-5-halophenyl pyrrolo precursors 4a-c ... -
Stereoselective facile synthesis of 2 '-spiro pyrimidine pyranonucleosides via their key intermediate 2 '-C-cyano analogues. Evaluation of their bioactivity
Kiritsis, C.; Manta, S.; Dimopoulou, A.; Parmenopoulou, V.; Gkizis, P.; Balzarini, J.; Komiotis, D. (2014)A novel series of 2'-spiro pyrimidine pyranonucleosides has been designed and synthesized. Their precursors, 2'-C-cyano nucleosides 5a,b and 6a,b, were obtained by subjecting 1a,b to the sequence of selective protection ... -
Synthesis of Novel Thiopurine Pyranonucleosides: Evaluation of Their Bioactivity
Dimopoulou, A.; Manta, S.; Parmenopoulou, V.; Gkizis, P.; Coutouli-Argyropoulou, E.; Schols, D.; Komiotis, D. (2015)We report the synthesis of novel thiopurine pyranonucleosides. Direct coupling of silylated 6-mercaptopurine and 6-thioguanine with the appropriate pyranoses 1a-e via Vorbruggen nucleosidation, gave the N-9 linked ...