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    • The Association of Spondylitis and Aortic Aneurysm Disease 

      Patelis N., Nana P., Spanos K., Tasoudis P., Brotis A., Bisdas T., Kouvelos G. (2021)
      Objectives: The aim of this study is to assess any relation between spondylitis and aortic aneurysmal disease by reviewing the current literature. Methods: A systematic search was undertaken using MEDLINE, EMBASE and CENTRAL ...

    • Associations between change in blood pressure and functional outcome, early events and death: Results from the Efficacy of Nitric Oxide in Stroke trial 

      Sandset E.C., Appleton J.P., Berge E., Christensen H., Gommans J., Krishnan K., Ntaios G., Phillips S., Pocock S., Sprigg N., Woodhouse L.J., Bath P.M. (2019)
      Objectives:High blood pressure (BP) is associated with a poor outcome after acute stroke. Early reduction in BP may be associated with fewer early adverse events and deaths, and improved functional outcome.Methods:Analyses ...

    • ASTRAL, DRAGON and SEDAN scores predict stroke outcome more accurately than physicians 

      Ntaios G., Gioulekas F., Papavasileiou V., Strbian D., Michel P. (2016)
      Background and purpose: ASTRAL, SEDAN and DRAGON scores are three well-validated scores for stroke outcome prediction. Whether these scores predict stroke outcome more accurately compared with physicians interested in ...

    • Automated oxygen delivery in hospitalized patients with acute respiratory failure: A pilot study 

      Malli F., Boutlas S., Lioufas N., Gourgoulianis K.I. (2019)
      Background and Objectives. Despite its' proven benefits, oxygen therapy may be complicated with potential adverse events such as hypoxemia or hyperoxia-driven hypercapnia. Automated oxygen delivery systems may aid in ...

    • Beneficial Effect of Multidomain Cognitive Training on the Neuropsychological Performance of Patients with Early-Stage Alzheimer's Disease 

      Nousia A., Siokas V., Aretouli E., Messinis L., Aloizou A.-M., Martzoukou M., Karala M., Koumpoulis C., Nasios G., Dardiotis E. (2018)
      Background and Purpose. There is an increasing interest in the effect of nonpharmacological interventions on the course of patients with Alzheimer's disease (AD). The objective of the present study is to determine the ...

    • Bilateral Pleural Effusion in Rheumatoid Arthritis: Think Beyond the Obvious 

      Dimeas I.E., Sinis S.I., Dimeas G.E., Daniil Z. (2022)
      An 86-year-old woman, non-smoker, with a medical history of rheumatoid arthritis for 20 years (stable at 5mg of prednisolone) was referred from a peripheral hospital to the Department of Respiratory Medicine of our tertiary ...

    • Carcinoembryonic antigen and carbohydrate antigen 19-9 serum levels in non-small cell lung cancer 

      Tsoukalas N., Kostakis I.D., Giaginis C., Tolia M., Galanopoulos M., Kiakou M., Aravantinou-Fatorou E., Tsapakidis K., Baxevanos P., Litos I., Tzouda V., Tzovaras A., Kyrgias G., Tsiambas E., Theocharis S. (2017)
      Purpose: Τo investigate the potential diagnostic and prognostic role of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9) serum levels in non-small cell lung cancer (NSCLC). Methods: One hundred ...

    • Care of Patients with Alzheimer’s Disease 

      Athanasiadou E., Tsaloglidou A., Koukourikos K., Papathanasiou I.V., Iliadis C.H., Frantzana A., Fradelos E., Kourkouta L. (2021)
      Introduction: Alzheimer’s disease is one of the irreversible dementias and leads to death. About 10% of people over 60 years and 20% of people over 80 will have Alzheimer’s sometime in their lives. In the case of Alzheimer’s ...

    • Carotid plaques and detection of atrial fibrillation in embolic stroke of undetermined source 

      Ntaios G., Perlepe K., Sirimarco G., Strambo D., Eskandari A., Karagkiozi E., Vemmou A., Koroboki E., Manios E., Makaritsis K., Michel P., Vemmos K. (2019)
      OBJECTIVE: To investigate the association between the presence of ipsilateral nonstenotic carotid plaques and the rate of detection of atrial fibrillation (AF) during follow-up in patients with embolic strokes of undetermined ...

    • Case Series: Bilateral Homonymous Visual Field Defects Due to Bilateral Ischemic Strokes 

      Papageorgiou E., Anthis N., Stathi T., Tsironi E., Asproudis I. (2018)
      SIGNIFICANCE Bilateral strokes are rare and should be considered when patients present with bilateral visual field loss characterized by patterns consistent with right and left-sided homonymous visual field defects. ...

    • Causes and Risk Factors of Cerebral Ischemic Events in Patients with Atrial Fibrillation Treated with Non-Vitamin K Antagonist Oral Anticoagulants for Stroke Prevention: The RENo Study 

      Paciaroni M., Agnelli G., Caso V., Silvestrelli G., Seiffge D.J., Engelter S., De Marchis G.M., Polymeris A., Zedde M.L., Yaghi S., Michel P., Eskandari A., Antonenko K., Sohn S.-I., Cappellari M., Tassinari T., Tassi R., Masotti L., Katsanos A.H., Giannopoulos S., Acciarresi M., Alberti A., Venti M., Mosconi M.G., Vedovati M.C., Pierini P., Giustozzi M., Lotti E.M., Ntaios G., Kargiotis O., Monaco S., Lochner P., Bandini F., Liantinioti C., Palaiodimou L., Abdul-Rahim A.H., Lees K., Mancuso M., Pantoni L., Rosa S., Bertora P., Galliazzo S., Ageno W., Toso E., Angelini F., Chiti A., Orlandi G., Denti L., Flomin Y., Marcheselli S., Mumoli N., Rimoldi A., Verrengia E., Schirinzi E., Del Sette M., Papamichalis P., Komnos A., Popovic N., Zarkov M., Rocco A., Diomedi M., Giorli E., Ciccone A., Grory B.C.M., Furie K.L., Bonetti B., Saia V., Guideri F., Acampa M., Martini G., Grifoni E., Padroni M., Karagkiozi E., Perlepe K., Makaritsis K., Mannino M., MacCarrone M., Ulivi L., Giannini N., Ferrari E., Pezzini A., Doronin B., Volodina V., Baldi A., D'Amore C., Deleu D., Corea F., Putaala J., Santalucia P., Nardi K., Risitano A., Toni D., Tsivgoulis G. (2019)
      Background and Purpose-Despite treatment with oral anticoagulants, patients with nonvalvular atrial fibrillation (AF) may experience ischemic cerebrovascular events. The aims of this case-control study in patients with AF ...

    • Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: The Right to Sight: An analysis for the Global Burden of Disease Study 

      Bourne R.R.A., Steinmetz J.D., Saylan M., Mersha A.M., Weldemariam A.H., Wondmeneh T.G., Sreeramareddy C.T., Pinheiro M., Yaseri M., Yu C., Zastrozhin M.S., Zastrozhina A., Zhang Z.-J., Zimsen S.R.M., Yonemoto N., Tsegaye G.W., Vu G.T., Vongpradith A., Renzaho A.M.N., Sorrie M.B., Shaheen A.A., Shiferaw W.S., Skryabin V.Y., Skryabina A.A., Saya G.K., Rahimi-Movaghar V., Shigematsu M., Sahraian M.A., Naderifar H., Sabour S., Rathi P., Sathian B., Miller T.R., Rezapour A., Rawal L., Pham H.Q., Parekh U., Podder V., Onwujekwe O.E., Pasovic M., Otstavnov N., Negash H., Pawar S., Naimzada M.D., Al Montasir A., Ogbo F.A., Owolabi M.O., Pakshir K., Mohammad Y., Moni M.A., Nunez-Samudio V., Mulaw G.F., Naveed M., Maleki S., Michalek I.M., Misra S., Swamy S.N., Mohammed J.A., Flaxman S., Park E.-C., Briant P.S., Meles G.G., Hayat K., Landires I., Kim G.R., Liu X., LeGrand K.E., Taylor H.R., Kunjathur S.M., Khoja T.A.M., Bicer B.K., Khalilov R., Hashi A., Kayode G.A., Carneiro V.L.A., Kavetskyy T., Kosen S., Kulkarni V., Holla R., Kalhor R., Jayaram S., Islam S.M.S., Gilani S.A., Eskandarieh S., Molla M.D., Itumalla R., Farzadfar F., Congdon N.G., Elhabashy H.R., Elayedath R., Couto R.A.S., Dervenis N., Cromwell E.A., Dahlawi S.M.A., Resnikoff S., Casson R.J., Abdoli A., Choi J.-Y.J., Dos Santos F.L.C., Abrha W.A., Nagaraja S.B., Abualhasan A., Adal T.G., Aregawi B.B., Beheshti M., Abu-Gharbieh E., Afshin A., Ahmadieh H., Alemzadeh S.A., Arrigo A., Atnafu D.D., Ashbaugh C., Ashrafi E., Alemayehu W., Alfaar A.S., Alipour V., Anbesu E.W., Androudi S., Arabloo J., Arditi A., Bagli E., Baig A.A., Bärnighausen T.W., Parodi M.B., Bhagavathula A.S., Bhardwaj N., Bhardwaj P., Bhattacharyya K., Bijani A., Bikbov M., Bottone M., Braithwaite T., Bron A.M., Butt Z.A., Cheng C.-Y., Chu D.-T., Cicinelli M.V., Coelho J.M., Dai X., Dana R., Dandona L., Dandona R., Del Monte M.A., Deva J.P., Diaz D., Djalalinia S., Dreer L.E., Ehrlich J.R., Ellwein L.B., Emamian M.H., Fernandes A.G., Fischer F., Friedman D.S., Furtado J.M., Gaidhane S., Gazzard G., Gebremichael B., George R., Ghashghaee A., Golechha M., Hamidi S., Hammond B.R., Hartnett M.E.R., Hartono R.K., Hay S.I., Heidari G., Ho H.C., Househ M., Ibitoye S.E., Ilic I.M., Huang J.J., Ilic M.D., Ingram A.D., Irvani S.S.N., Jha R.P., Kahloun R., Kandel H., Kasa A.S., Kempen J.H., Khairallah M., Khan E.A., Khanna R.C., Khatib M.N., Kim J.E., Kim Y.J., Kisa A., Kisa S., Koyanagi A., Kurmi O.P., Lansingh V.C., Leasher J.L., Leveziel N., Limburg H., Manafi N., Mansouri K., McAlinden C., Mohammadi S.F., Mokdad A.H., Morse A.R., Naderi M., Naidoo K.S., Nangia V., Nguyen H.L.T., Ogundimu K., Olagunju A.T., Panda-Jonas S., Pesudovs K., Peto T., Ur Rahman M.H., Ramulu P.Y., Rawaf D.L., Rawaf S., Reinig N., Robin A.L., Rossetti L., Safi S., Sahebkar A., Samy A.M., Serle J.B., Shaikh M.A., Shen T.T., Shibuya K., Shin J.I., Silva J.C., Silvester A., Singh J.A., Singhal D., Sitorus R.S., Skiadaresi E., Soheili A., Sousa R.A.R.C., Stambolian D., Tadesse E.G., Tahhan N., Tareque Md.I., Topouzis F., Tran B.X., Tsilimbaris M.K., Varma R., Virgili G., Wang N., Wang Y.X., West S.K., Wong T.Y., Jonas J.B., Vos T., GBD 2019 Blindness and Vision Impairment Collaborators, Vision Loss Expert Group of the Global Burden of Disease Study (2021)
      Background: Many causes of vision impairment can be prevented or treated. With an ageing global population, the demands for eye health services are increasing. We estimated the prevalence and relative contribution of ...

    • Characteristics and Outcomes in Patients with COVID-19 and Acute Ischemic Stroke: The Global COVID-19 Stroke Registry 

      Ntaios G., Michel P., Georgiopoulos G., Guo Y., Li W., Xiong J., Calleja P., Ostos F., González-Ortega G., Fuentes B., Alonso De Leciñana M., Díez-Tejedor E., García-Madrona S., Masjuan J., Defelipe A., Turc G., Gonçalves B., Domigo V., Dan G.-A., Vezeteu R., Christensen H., Christensen L.M., Meden P., Hajdarevic L., Rodriguez-Lopez A., Díaz-Otero F., García-Pastor A., Gil-Nuñez A., Maslias E., Strambo D., Werring D.J., Chandratheva A., Benjamin L., Simister R., Perry R., Beyrouti R., Jabbour P., Sweid A., Tjoumakaris S., Cuadrado-Godia E., Campello A.R., Roquer J., Moreira T., Mazya M.V., Bandini F., Matz K., Iversen H.K., González-Duarte A., Tiu C., Ferrari J., Vosko M.R., Salzer H.J.F., Lamprecht B., Dünser M.W., Cereda C.W., Quintero Á.B.C., Korompoki E., Soriano-Navarro E., Soto-Ramírez L.E., Castañeda-Méndez P.F., Bay-Sansores D., Arauz A., Cano-Nigenda V., Kristoffersen E.S., Tiainen M., Strbian D., Putaala J., Lip G.Y.H. (2020)
      Recent case-series of small size implied a pathophysiological association between coronavirus disease 2019 (COVID-19) and severe large-vessel acute ischemic stroke. Given that severe strokes are typically associated with ...

    • Characteristics of Long-Term Survival in Patients With Myelodysplastic Syndrome Treated With 5-Azacyditine: Results From the Hellenic 5-Azacytidine Registry 

      Diamantopoulos P.T., Pappa V., Symeonidis A., Kotsianidis I., Galanopoulos A., Papadaki H., Anagnostopoulos A., Vassilopoulos G., Zikos P., Hatzimichael E., Papaioannou M., Megalakaki A., Kotsopoulou M., Repousis P., Dimou M., Solomou E., Pontikoglou C., Kyriakakis G., Tsokanas D., Papoutselis M.-K., Papageorgiou S., Kourakli A., Panayiotidis P., Viniou N.-A. (2020)
      Background: Hypomethylating agents have altered the prognosis of myelodysplastic syndrome (MDS) so that long-term survival is now a feasible treatment goal. Patients and Methods: We analyzed data from patients with MDS ...

    • Characterization of Patients with Embolic Strokes of Undetermined Source in the NAVIGATE ESUS Randomized Trial 

      Kasner S.E., Lavados P., Sharma M., Wang Y., Wang Y., Dávalos A., Shamalov N., Cunha L., Lindgren A., Mikulik R., Arauz A., Lang W., Czlonkowska A., Eckstein J., Gagliardi R., Amarenco P., Ameriso S.F., Tatlisumak T., Veltkamp R., Hankey G.J., Toni D.S., Bereczki D., Uchiyama S., Ntaios G., Yoon B.-W., Brouns R., DeVries Basson M.M., Endres M., Muir K., Bornstein N., Ozturk S., O'Donnell M., Mundl H., Pater C., Weitz J., Peacock W.F., Swaminathan B., Kirsch B., Berkowitz S.D., Peters G., Pare G., Themeles E., Shoamanesh A., Connolly S.J., Hart R.G., NAVIGATE ESUS Steering Committee and Investigators (2018)
      Background: The New Approach Rivaroxaban Inhibition of Factor Xa in a Global Trial vs. ASA to Prevent Embolism in Embolic Stroke of Undetermined Source (NAVIGATE-ESUS) trial is a randomized phase-III trial comparing ...

    • Chronic obstructive pulmonary disease as a main factor of premature aging 

      Karametos I., Tsiboli P., Togousidis I., Hatzoglou C., Giamouzis G., Gourgoulianis K.I. (2019)
      (1) Background: Chronic obstructive pulmonary disease (COPD) is defined as an inflammatory disorder that presents an increasingly prevalent health problem. Accelerated aging has been examined as a pathologic mechanism of ...

    • Classification of COPD patients and compliance to recommended treatment in Greece according to GOLD 2017 report: the RELICO study 

      Tzanakis N., Koulouris N., Dimakou K., Gourgoulianis K., Kosmas E., Chasapidou G., Konstantinidis A., Kyriakopoulos C., Kontakiotis T., Rapti A., Gaga M., Kalafatakis K., Kostikas K. (2021)
      Background: Chronic obstructive pulmonary disease (COPD) is a multifactorial clinical condition, characterized by chronic progressive (or worsening) respiratory symptoms, structural pulmonary abnormalities, and impaired ...

    • Clinical features and outcomes of patients with tubercular uveitis treated with antitubercular therapy in the collaborative ocular tuberculosis study (COTS)-1 

      Agrawal R., Gunasekeran D.V., Grant R., Agarwal A., Kon O.M., Nguyen Q.D., Pavesio C., Gupta V., Gupta B., Aggarwal K., Murthy S.L., Westcott M., Phaik C.S., McCluskey P., Ling H.S., Teoh S., Cimino L., Biswas J., Narain S., Agarwal M., Mahendradas P., Khairallah M., Jones N., Tugal-Tutkun I., Babu K., Basu S., Carreño E., Lee R., Al-Dhibi H., Bodaghi B., Invernizzi A., Goldstein D.A., Herbort C.P., Barisani T., González-López J.J., Androudi S., Bansal R., Moharana B., Mahajan S., Esposti S., Tasiopoulou A., Nadarajah S., Agarwal M., Abraham S., Vala R., Singh R., Sharma A., Sharma K., Zierhut M., Raje D., Cunningham E., Kempen J., Collaborative Ocular Tuberculosis Study (COTS)-1 Study Group (2017)
      IMPORTANCE Eradication of systemic tuberculosis (TB) has been limited by neglected populations and the HIV pandemic. Whereas ocular TB often presents as uveitis without any prior evidence of systemic TB, the existing ...

    • Clinical outcomes and neuroimaging profiles in nondisabled patients with anticoagulant-related intracerebral hemorrhage 

      Lioutas V.-A., Goyal N., Katsanos A.H., Krogias C., Zand R., Sharma V.K., Varelas P., Malhotra K., Paciaroni M., Sharaf A., Chang J., Karapanayiotides T., Kargiotis O., Pappa A., Mai J., Pandhi A., Schroeder C., Tsantes A., Mehta C., Kerro A., Khan A., Mitsias P.D., Selim M.H., Alexandrov A.V., Tsivgoulis G. (2018)
      Background and Purpose: The aim of this study was to prospectively validate our prior findings of smaller hematoma volume and lesser neurological deficit in nonvitamin K oral anticoagulant (NOAC) compared with Vitamin K ...

    • Clinical risk scores for the prediction of incident atrial fibrillation: a modernized review 

      Louka A.M., Tsagkaris C., Stoica A. (2021)
      Atrial fibrillation (AF) is considered the most common sustained arrhythmia. Major cardiovascular risk factors that have been identified to initiate and perpetuate AF include age, sex, arterial hypertension, heart failure, ...