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    • Banded vs. non-banded Roux-en-Y gastric bypass for morbid obesity: a systematic review and meta-analysis 

      Magouliotis D.E., Tasiopoulou V.S., Svokos K.A., Svokos A.A., Sioka E., Tzovaras G., Zacharoulis D. (2018)
      We aim to review the available literature on patients with morbid obesity treated with banded (BRYGB) or non-banded Roux-en-Y gastric bypass (NBRYGB), in order to compare the clinical outcomes and intraoperative parameters ...

    • BDNF rs6265 (Val66Met) Polymorphism as a Risk Factor for Blepharospasm 

      Siokas V., Kardaras D., Aloizou A.-M., Asproudis I., Boboridis K.G., Papageorgiou E., Hadjigeorgiou G.M., Tsironi E.E., Dardiotis E. (2019)
      A few genetic variants are implicated in the development of blepharospasm (BSP). The precise role of the rs6265 on the brain-derived neurotrophic factor (BDNF) gene on BSP remains controversial. The effect of rs6265 on BSP ...

    • Benefits and Limitations of TKIs in Patients with Medullary Thyroid Cancer: A Systematic Review and Meta-Analysis 

      Efstathiadou Z.A., Tsentidis C., Bargiota A., Daraki V., Kotsa K., Ntali G., Papanastasiou L., Tigas S., Toulis K., Pazaitou-Panayiotou K., Alevizaki M. (2021)
      Introduction: Tyrosine kinase inhibitors (TKIs) have been used in patients with advanced medullary thyroid carcinoma (MTC); however, data on their effectiveness and safety are limited. The aim of this systematic review and ...

    • Bioavailability, Efficacy and Safety of Generic Immunosuppressive Drugs for Kidney Transplantation: A Systematic Review and Meta-Analysis 

      Tsipotis E., Gupta N.R., Raman G., Zintzaras E., Jaber B.L. (2016)
      Background: Concerns exist over the extrapolation of bioavailability studies of generic immunosuppressive drugs in healthy volunteers, regarding their efficacy and safety in kidney transplant recipients. We conducted a ...

    • Bleeding risk comparison between direct oral anticoagulants at doses approved for atrial fibrillation and aspirin: systematic review, meta-analysis and meta-regression 

      Sagris D., Leventis I., Georgiopoulos G., Korompoki E., Makaritsis K., Vemmos K., Milionis H., Lip G.Y.H., Ntaios G. (2020)
      Background: A considerable proportion of patients with atrial fibrillation (AF) are still treated with aspirin despite current guidelines due to presumed favorable safety. Aim: We performed a systematic review and meta-analysis ...

    • Body mass index and survival from amyotrophic lateral sclerosis: A meta-analysis 

      Dardiotis E., Siokas V., Sokratous M., Tsouris Z., Aloizou A.-M., Florou D., Dastamani M., Mentis A.-F.A., Brotis A.G. (2018)
      BackgroundSeveral studies have examined the relationship between body mass index (BMI) and survival from amyotrophic lateral sclerosis (ALS). Many indicate that low BMI at diagnosis or during follow-up may be associated ...

    • Body mass index in patients with Multiple Sclerosis: a meta-analysis 

      Dardiotis E., Tsouris Z., Aslanidou P., Aloizou A.-M., Sokratous M., Provatas A., Siokas V., Deretzi G., Hadjigeorgiou G.M. (2019)
      Background: The impact of nutrition and diet on the etiology of Multiple Sclerosis (MS) has been evaluated through a number of studies. Only a limited number reported findings on the association between body mass index ...

    • Breast radiotherapy and early adverse cardiac effects. The role of serum biomarkers and strain echocardiography 

      Gkantaifi A., Papadopoulos C., Spyropoulou D., Toumpourleka M., Iliadis G., Kardamakis D., Nikolaou M., Tsoukalas N., Kyrgias G., Tolia M. (2019)
      Breast cancer radiotherapy has a clear benefit for both long-term survival and local recurrence rate. However, there is still much concern about the early radiation-induced heart toxicity. This article aimed to clarify the ...

    • Cardiotoxicity of Chemical Substances: An Emerging Hazard Class 

      Georgiadis N., Tsarouhas K., Dorne J.-L.C.M., Kass G.E.N., Laspa P., Toutouzas K., Koulaouzidou E.A., Kouretas D., Tsitsimpikou C. (2022)
      (1) Background: Human health risks and hazards from chemical substances are well regulated internationally. However, cardiotoxicity, is not defined as a stand-alone hazard and therefore there are no defined criteria for ...

    • Carotid Intima-Media Thickness Progression as Surrogate Marker for Cardiovascular Risk: Meta-Analysis of 119 Clinical Trials Involving 100 667 Patients 

      Willeit P., Tschiderer L., Allara E., Reuber K., Seekircher L., Gao L., Liao X., Lonn E., Gerstein H.C., Yusuf S., Brouwers F.P., Asselbergs F.W., Van Gilst W., Anderssen S.A., Grobbee D.E., Kastelein J.J.P., Visseren F.L.J., Ntaios G., Hatzitolios A.I., Savopoulos C., Nieuwkerk P.T., Stroes E., Walters M., Higgins P., Dawson J., Gresele P., Guglielmini G., Migliacci R., Ezhov M., Safarova M., Balakhonova T., Sato E., Amaha M., Nakamura T., Kapellas K., Jamieson L.M., Skilton M., Blumenthal J.A., Hinderliter A., Sherwood A., Smith P.J., Van Agtmael M.A., Reiss P., Van Vonderen M.G.A., Kiechl S., Klingenschmid G., Sitzer M., Stehouwer C.D.A., Uthoff H., Zou Z.-Y., Cunha A.R., Neves M.F., Witham M.D., Park H.-W., Lee M.-S., Bae J.-H., Bernal E., Wachtell K., Kjeldsen S.E., Olsen M.H., Preiss D., Sattar N., Beishuizen E., Huisman M.V., Espeland M.A., Schmidt C., Agewall S., Ok E., Aşçi G., De Groot E., Grooteman M.P.C., Blankestijn P.J., Bots M.L., Sweeting M.J., Thompson S.G., Lorenz M.W. (2020)
      Background: To quantify the association between effects of interventions on carotid intima-media thickness (cIMT) progression and their effects on cardiovascular disease (CVD) risk. Methods: We systematically collated data ...

    • Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: The Right to Sight: An analysis for the Global Burden of Disease Study 

      Bourne R.R.A., Steinmetz J.D., Saylan M., Mersha A.M., Weldemariam A.H., Wondmeneh T.G., Sreeramareddy C.T., Pinheiro M., Yaseri M., Yu C., Zastrozhin M.S., Zastrozhina A., Zhang Z.-J., Zimsen S.R.M., Yonemoto N., Tsegaye G.W., Vu G.T., Vongpradith A., Renzaho A.M.N., Sorrie M.B., Shaheen A.A., Shiferaw W.S., Skryabin V.Y., Skryabina A.A., Saya G.K., Rahimi-Movaghar V., Shigematsu M., Sahraian M.A., Naderifar H., Sabour S., Rathi P., Sathian B., Miller T.R., Rezapour A., Rawal L., Pham H.Q., Parekh U., Podder V., Onwujekwe O.E., Pasovic M., Otstavnov N., Negash H., Pawar S., Naimzada M.D., Al Montasir A., Ogbo F.A., Owolabi M.O., Pakshir K., Mohammad Y., Moni M.A., Nunez-Samudio V., Mulaw G.F., Naveed M., Maleki S., Michalek I.M., Misra S., Swamy S.N., Mohammed J.A., Flaxman S., Park E.-C., Briant P.S., Meles G.G., Hayat K., Landires I., Kim G.R., Liu X., LeGrand K.E., Taylor H.R., Kunjathur S.M., Khoja T.A.M., Bicer B.K., Khalilov R., Hashi A., Kayode G.A., Carneiro V.L.A., Kavetskyy T., Kosen S., Kulkarni V., Holla R., Kalhor R., Jayaram S., Islam S.M.S., Gilani S.A., Eskandarieh S., Molla M.D., Itumalla R., Farzadfar F., Congdon N.G., Elhabashy H.R., Elayedath R., Couto R.A.S., Dervenis N., Cromwell E.A., Dahlawi S.M.A., Resnikoff S., Casson R.J., Abdoli A., Choi J.-Y.J., Dos Santos F.L.C., Abrha W.A., Nagaraja S.B., Abualhasan A., Adal T.G., Aregawi B.B., Beheshti M., Abu-Gharbieh E., Afshin A., Ahmadieh H., Alemzadeh S.A., Arrigo A., Atnafu D.D., Ashbaugh C., Ashrafi E., Alemayehu W., Alfaar A.S., Alipour V., Anbesu E.W., Androudi S., Arabloo J., Arditi A., Bagli E., Baig A.A., Bärnighausen T.W., Parodi M.B., Bhagavathula A.S., Bhardwaj N., Bhardwaj P., Bhattacharyya K., Bijani A., Bikbov M., Bottone M., Braithwaite T., Bron A.M., Butt Z.A., Cheng C.-Y., Chu D.-T., Cicinelli M.V., Coelho J.M., Dai X., Dana R., Dandona L., Dandona R., Del Monte M.A., Deva J.P., Diaz D., Djalalinia S., Dreer L.E., Ehrlich J.R., Ellwein L.B., Emamian M.H., Fernandes A.G., Fischer F., Friedman D.S., Furtado J.M., Gaidhane S., Gazzard G., Gebremichael B., George R., Ghashghaee A., Golechha M., Hamidi S., Hammond B.R., Hartnett M.E.R., Hartono R.K., Hay S.I., Heidari G., Ho H.C., Househ M., Ibitoye S.E., Ilic I.M., Huang J.J., Ilic M.D., Ingram A.D., Irvani S.S.N., Jha R.P., Kahloun R., Kandel H., Kasa A.S., Kempen J.H., Khairallah M., Khan E.A., Khanna R.C., Khatib M.N., Kim J.E., Kim Y.J., Kisa A., Kisa S., Koyanagi A., Kurmi O.P., Lansingh V.C., Leasher J.L., Leveziel N., Limburg H., Manafi N., Mansouri K., McAlinden C., Mohammadi S.F., Mokdad A.H., Morse A.R., Naderi M., Naidoo K.S., Nangia V., Nguyen H.L.T., Ogundimu K., Olagunju A.T., Panda-Jonas S., Pesudovs K., Peto T., Ur Rahman M.H., Ramulu P.Y., Rawaf D.L., Rawaf S., Reinig N., Robin A.L., Rossetti L., Safi S., Sahebkar A., Samy A.M., Serle J.B., Shaikh M.A., Shen T.T., Shibuya K., Shin J.I., Silva J.C., Silvester A., Singh J.A., Singhal D., Sitorus R.S., Skiadaresi E., Soheili A., Sousa R.A.R.C., Stambolian D., Tadesse E.G., Tahhan N., Tareque Md.I., Topouzis F., Tran B.X., Tsilimbaris M.K., Varma R., Virgili G., Wang N., Wang Y.X., West S.K., Wong T.Y., Jonas J.B., Vos T., GBD 2019 Blindness and Vision Impairment Collaborators, Vision Loss Expert Group of the Global Burden of Disease Study (2021)
      Background: Many causes of vision impairment can be prevented or treated. With an ageing global population, the demands for eye health services are increasing. We estimated the prevalence and relative contribution of ...

    • Cecorectal (CRA) versus ileorectal (IRA) anastomosis after colectomy for slow transit constipation (STC): a meta-analysis 

      Perivoliotis K., Baloyiannis I., Tzovaras G. (2022)
      Introduction: We conducted this meta-analysis, to compare cecorectal (CRA) and ileorectal anastomosis (IRA), regarding perioperative safety and efficacy, in patients submitted to colectomy for refractory slow transit ...

    • Circulating biomarkers for the prediction of abdominal aortic aneurysm growth 

      Nana P., Dakis K., Brodis A., Spanos K., Kouvelos G. (2021)
      Background: Abdominal aortic aneurysm represents a distinct group of vascular lesions, in terms of surveillance and treatment. Screening and follow-up of patients via duplex ultrasound has been well established and proposed ...

    • Clinical effect of accessory renal artery coverage after endovascular repair of aneurysms in abdominal and thoracoabdominal aorta 

      Spanos K., Nana P., Brotis A.G., Kouvelos G., Behrendt C.-A., Tsilimparis N., Kölbel T., Matsagkas M., Giannoukas A. (2021)
      Background: The aim of our systematic review and meta-analysis was to assess the effect of accessory renal artery (ARA) coverage on renal function in terms of acute kidney injury (AKI), renal infarction, chronic renal ...

    • Clinical value of significance of hypoxia inducible factor-1α, glucose transporter-1 and carbonic anhydrase IX in rectal cancer after preoperative chemoradiotherapy 

      Vitoratou D.-I., Tolia M., Liakos P., Tsoukalas N., Giaginis C., Nikolaou M., Nikolaou G., Rigas G., Psarianos K., Lioupis A., Kyrgias G. (2019)
      Purpose: The standard treatment of rectal cancer is surgery along with preoperative radiotherapy, administered alone or in combination with chemotherapy. Preoperative chemoradiotherapy (preCRT) is widely used as it allows ...

    • Clinical, functional and radiographic outcomes after revision total hip arthroplasty with tapered fluted modular or non-modular stems: a systematic review 

      Koutalos A.A., Varitimidis S., Malizos K.N., Karachalios T. (2022)
      Purpose: The aim of the study was to systematically evaluate clinical outcomes of tapered fluted stems, either monoblock or modular, in revision total hip arthroplasty. Methods: PubMed, EMBASE and Web of Science and Cochrane ...

    • Clipping Versus Coiling in Anterior Circulation Ruptured Intracranial Aneurysms: A Meta-Analysis 

      Fotakopoulos G., Tsianaka E., Fountas K., Makris D., Spyrou M., Hernesniemi J. (2017)
      Objective To evaluate open surgical versus endovascular repair of anterior circulation ruptured intracranial aneurysms based on operative mortality, permanent neurologic deficit, late mortality, and need for reintervention. ...

    • Clopidogrel Monotherapy versus Aspirin Monotherapy in Patients with Established Cardiovascular Disease: Systematic Review and Meta-Analysis 

      Tasoudis P.T., Kyriakoulis I.G., Sagris D., Diener H.C., Ntaios G. (2022)
      Background There is no clear consensus on whether aspirin offers better outcomes in terms of secondary cardiovascular disease prevention compared with clopidogrel. Objective The aim of the study was to compare the safety ...

    • Closure of Mesenteric Defects in Laparoscopic Gastric Bypass: a Meta-Analysis 

      Magouliotis D.E., Tzovaras G., Tasiopoulou V.S., Christodoulidis G., Zacharoulis D. (2020)
      Introduction: The purpose of the current study was to review the available literature on morbidly obese patients treated with laparoscopic Roux-en-Y gastric bypass (LRYGB) in order to assess the clinical outcomes of the ...

    • Closure of patent foramen ovale versus medical therapy in patients with cryptogenic stroke or transient ischemic attack: Updated systematic review and meta-analysis 

      Ntaios G., Papavasileiou V., Sagris D., Makaritsis K., Vemmos K., Steiner T., Michel P. (2018)
      Background and Purpose: Previous systematic reviews and meta-analyses compared the efficacy and safety of patent foramen ovale (PFO) closure versus medical treatment in patients with cryptogenic stroke or transient ischemic ...