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Browsing by Subject "melanoma"

Now showing items 21-24 of 24

    • The role of histone deacetylase inhibitors in uveal melanoma: Current evidence 

      Moschos M.M., Dettoraki M., Androudi S., Kalogeropoulos D., Lavaris A., Garmpis N., Damaskos C., Garmpi A., Tsatsos M. (2018)
      Uveal melanoma is the most common intraocular malignancy in adults, representing approximately 3% of all melanoma cases. Despite progress in chemotherapy, radiation and surgical treatment options, the prognosis and survival ...

    • The role of MiRNA-21 in gliomas: Hope for a novel therapeutic intervention? 

      Aloizou A.-M., Pateraki G., Siokas V., Mentis A.-F.A., Liampas I., Lazopoulos G., Kovatsi L., Mitsias P.D., Bogdanos D.P., Paterakis K., Dardiotis E. (2020)
      Gliomas are the most common primary brain tumors in adults. They are generally very resistant to treatment and are therefore associated with negative outcomes. MicroRNAs (miRNAs) are small, non-coding RNA molecules that ...

    • A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression 

      Verginadis I.I., Avgousti H., Monslow J., Skoufos G., Chinga F., Kim K., Leli N.M., Karagounis I.V., Bell B.I., Velalopoulou A., Salinas C.S., Wu V.S., Li Y., Ye J., Scott D.A., Osterman A.L., Sengupta A., Weljie A., Huang M., Zhang D., Fan Y., Radaelli E., Tobias J.W., Rambow F., Karras P., Marine J.-C., Xu X., Hatzigeorgiou A.G., Ryeom S., Diehl J.A., Fuchs S.Y., Puré E., Koumenis C. (2022)
      Bidirectional signalling between the tumour and stroma shapes tumour aggressiveness and metastasis. ATF4 is a major effector of the Integrated Stress Response, a homeostatic mechanism that couples cell growth and survival ...

    • Transcription of the NKG2D ligand MICA is suppressed by the IRE1/XBP1 pathway of the unfolded protein response through the regulation of E2F1 

      Obiedat A., Seidel E., Mahameed M., Bernani O., Tsukerman P., Voutetakis K., Chatziioannou A., Mcmahon M., Avril T., Chevet E., Mandelboim O., Tirosh B. (2019)
      The unfolded protein response (UPR) is an adaptive signaling pathway activated in response to endoplasmic reticulum (ER) stress. The effectors of the UPR are potent transcription activators; however, some genes are suppressed ...