Browsing by Subject "RHEUMATOID-ARTHRITIS"
Now showing items 21-32 of 32
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Predictive role of cytokine gene polymorphisms for the development of femoral head osteonecrosis
(2012)Introduction: Osteonecrosis (ON) is a multifactorial disease that leads to hip destruction. Lately, much focus has been at femoral head preservation with nonsurgical methods. In this study we examined the polymorphisms of ... -
Protective Effect of Atorvastatin in Cultured Osteoarthritic Chondrocytes
(2010)The aim of our study was to evaluate the in vitro effect of an HMG-CoA reductase inhibitor, atorvastatin, on the expression of significant anabolic and catabolic genes in human osteoarthritic chondrocytes and to explore ... -
Proteomics of osteoarthritic chondrocytes and cartilage
(2010)Osteoarthritis (OA) is characterized by irreversible destruction of the articular cartilage. OA affects more than 100 million individuals worldwide and has a major impact on patients' quality of life. The lack of effective ... -
Rationally Designed Less Toxic SPD-304 Analogs and Preliminary Evaluation of Their TNF Inhibitory Effects
(2014)SPD-304 was discovered as a promising tumor necrosis factor alpha (TNF) antagonist that promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. However, SPD-304 contains a potentially ... -
Renal Manifestations and Complications of Inflammatory Bowel Disease
(2011)Renal manifestations and complications are not rare in patients with inflammatory bowel disease (IBD) and may present as nephrolithiasis, amyloidosis, tubulointerstitial nephritis, and glomerulonephritis. Symptoms of renal ... -
Risk Assessment of Tuberculosis in Immunocompromised Patients A TBNET Study
(2014)Rationale: In the absence of active tuberculosis, a positive tuberculin skin test (TST) or interferon-gamma release assay (IGRA) result defines latent infection with Mycobacterium tuberculosis, although test results may ... -
The role of stainless steel wire mesh and cement in bone allograft incorporation in impaction grafting technique - An experimental study in rabbits
(2003)Cages of flexible stainless steel wire mesh were filled with impacted morcellized cancellous allograft. Bone defects were created in both tibial metaphyseal regions of 10 adult white New Zealand rabbits. The base of both ... -
Simple and Reliable HPLC Method for the Monitoring of Methotrexate in Osteosarcoma Patients
(2014)Methotrexate (MTX) is a dihydrofolate reductase inhibitor that is used for the treatment of tumors and autoimmune diseases. Several automated binding assays are used in clinical practice and numerous chromatographic methods ... -
Sjogren's syndrome associated with systemic lupus erythematosus - Clinical and laboratory profiles and comparison with primary Sjogren's syndrome
(2004)Objective. To address the clinical, serologic, pathologic, and immunogenetic features of sicca syndrome that occurs in systemic lupus erythematosus (SLE), as well as its similarities to, and differences from, sicca syndrome ... -
Stress, coping strategies and social support in patients with primary Sjogren's syndrome prior to disease onset: a retrospective case-control study
(2009)Objectives: Previous evidence suggests the role of psychological stress in triggering the onset of auto-immunity. We aimed to investigate whether stress following major and minor life events could precede the onset of ... -
Synthesis and biological evaluation of potential small molecule inhibitors of tumor necrosis factor
(2015)Inhibition of tumor necrosis factor (TNF) production or function by small molecules has become a major focus in the pharmaceutical industry for the treatment of rheumatoid arthritis. In this study, a series of 39 novel ...