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Αποτελέσματα 21-28 από 28

    • Is there evidence to claim or deny association between variants of the multidrug resistance gene (MDR1 or ABCB1) and inflammatory bowel disease? 

      Zintzaras, E. (2012)
      Background: Inflammatory bowel disease (IBD) is a complex disease with a genetic background. Crohn's disease (CD) and ulcerative colitis (UC) are the two main types of IBD. There is indication that variants in the MDR1 ...

    • Large-Scale Analysis of Association Between GDF5 and FRZB Variants and Osteoarthritis of the Hip, Knee, and Hand 

      Evangelou, E.; Chapman, K.; Meulenbelt, I.; Karassa, F. B.; Loughlin, J.; Carr, A.; Doherty, M.; Doherty, S.; Gomez-Reino, J. J.; Gonzalez, A.; Halldorsson, B. V.; Hauksson, V. B.; Hofman, A.; Hart, D. J.; Ikegawa, S.; Ingvarsson, T.; Jiang, Q.; Jonsdottir, I.; Jonsson, H.; Kerkhof, H. J. M.; Kloppenburg, M.; Lane, N. E.; Li, J.; Lories, R. J.; van Meurs, J. B. J.; Nakki, A.; Nevitt, M. C.; Rodriguez-Lopez, J.; Shi, D. Q.; Slagboom, E.; Stefansson, K.; Tsezou, A.; Wallis, G. A.; Watson, C. M.; Spector, T. D.; Uitterlinden, A. G.; Valdes, A. M.; Ioannidis, J. P. A. (2009)
      Objective. GDF5 and FRZB have been proposed as genetic loci conferring susceptibility to osteoarthritis (OA); however, the results of several studies investigating the association of OA with the rs143383 polymorphism of ...

    • A large-scale replication study for the association of rs17039192 in HIF-2 alpha with knee osteoarthritis 

      Nakajima, M.; Shi, D. Q.; Dai, J.; Tsezou, A.; Zheng, M. H.; Norman, P. E.; Chou, C. H.; Lee, M. T. M.; Hwang, J. Y.; Kim, D. H.; Takahashi, A.; Ikegawa, S.; Jiang, Q. (2012)
      Osteoarthritis (OA) is a common disease with a genetic component for its etiology. Recently, a genetic association of a single nucleotide polymorphism (SNP), rs17039192 in HIF-2a with knee OA has been reported in a Japanese ...

    • Lower prevalence of epsilon 4 allele of apolipoprotein E gene in healthy, longer-lived individuals of hellenic origin 

      Stakias, N.; Liakos, P.; Tsiapali, E.; Goutou, M.; Koukoulis, G. N. (2006)
      Apolipoprotein E (ApoE), and especially its epsilon 4 isoform, is considered a risk factor predisposing to coronary heart disease. We hypothesized that the absence of epsilon 4 allele offers a better chance for longer life. ...

    • A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip 

      Evangelou, E.; Kerkhof, H. J.; Styrkarsdottir, U.; Ntzani, E. E.; Bos, S. D.; Esko, T.; Evans, D. S.; Metrustry, S.; Panoutsopoulou, K.; Ramos, Y. F. M.; Thorleifsson, G.; Tsilidis, K. K.; Arden, N.; Aslam, N.; Bellamy, N.; Birrell, F.; Blanco, F. J.; Carr, A.; Chapman, K.; Day-Williams, A. G.; Deloukas, P.; Doherty, M.; Engstrom, G.; Helgadottir, H. T.; Hofman, A.; Ingvarsson, T.; Jonsson, H.; Keis, A.; Keurentjes, J. C.; Kloppenburg, M.; Lind, P. A.; McCaskie, A.; Martin, N. G.; Milani, L.; Montgomery, G. W.; Nelissen, Rghh; Nevitt, M. C.; Nilsson, P. M.; Ollier, W. E. R.; Parimi, N.; Rai, A.; Ralston, S. H.; Reed, M. R.; Riancho, J. A.; Rivadeneira, F.; Rodriguez-Fontenla, C.; Southam, L.; Thorsteinsdottir, U.; Tsezou, A.; Awallis, G.; Wilkinson, J. M.; Gonzalez, A.; Lane, N. E.; Lohmander, L. S.; Loughlin, J.; Metspalu, A.; Uitterlinden, A. G.; Jonsdottir, I.; Stefansson, K.; Slagboom, P. E.; Zeggini, E.; Meulenbelt, I.; Ioannidis, J. P. A.; Spector, T. D.; van Meurs, J. B. J.; Valdes, A. M.; arc, Ogen Consortium (2014)
      Objectives Osteoarthritis (OA) is the most common form of arthritis with a clear genetic component. To identify novel loci associated with hip OA we performed a meta-analysis of genome-wide association studies (GWAS) on ...

    • Mitochondrial DNA variation in northeast atlantic and mediterranean populations of norway lobster, Nephrops norvegicus 

      Stamatis, C.; Triantafyllidis, A.; Moutou, K. A.; Mamuris, Z. (2004)
      Analysis of the genetic structure of the Norway lobster (Nephrops norvegicus), a marine crustacean with high commercial value, was undertaken to gain information regarding the differentiation of Atlantic from Mediterranean ...

    • Phylogeography of the brown hare (Lepus europaeus) in Europe: a legacy of south-eastern Mediterranean refugia? 

      Stamatis, C.; Suchentrunk, F.; Moutou, K. A.; Giacometti, M.; Haerer, G.; Djan, M.; Vapa, L.; Vukovic, M.; Tvrtkovic, N.; Sert, H.; Alves, P. C.; Mamuris, Z. (2009)
      We analysed the population genetics of the brown hare (Lepus europaeus) in order to test the hypothesis that this species migrated into central Europe from a number of late glacial refugia, including some in Asia Minor. ...

    • Potential Role of the Alcohol and Smoking in the Squamous Cell Carcinoma of the Head And Neck: Review of the Current Literature and New Perspectives 

      Zygogianni, A.; Kyrgias, G.; Mystakidou, K.; Antypas, C.; Kouvaris, J.; Papadimitriou, C.; Armonis, V.; Alkati, H.; Kouloulias, V. (2011)
      Alcohol and tobacco are responsible for a very large proportion of chronic disease and some tumors in particular may be the result of interactions between the two risk factors. The present systematic literature review was ...