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Πλοήγηση ανά Θέμα "GENE-EXPRESSION"

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    • Epigenetic Mechanisms and Kidney Diseases 

      Liakopoulos, V.; Georgianos, P. I.; Eleftheriadis, T.; Sarafidis, P. A. (2011)
      In recent years, molecular research has brought to light a series of mechanisms involved in the regulation of gene function without altering the DNA sequence. These mechanisms are described with the term "epigenetics" and ...

    • Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention 

      Iliopoulos, D.; Malizos, K. N.; Tsezou, A. (2007)
      Objective: To investigate whether epigenetic mechanisms can regulate leptin's expression and affect its downstream targets as metalloproteinases 3,9,13 in osteoarthritic chondrocytes. Methods: DNA methylation in leptin ...

    • Exposure of differentiated airway smooth muscle cells to serum stimulates both induction of hypoxia-inducible factor-1 alpha and airway responsiveness to ACh 

      Chachami, G.; Hatziefthimiou, A.; Liakos, P.; Ioannou, M. G.; Koukoulis, G. K.; Bonanou, S.; Molyvdas, P. A.; Simos, G.; Paraskeva, E. (2007)
      Airway smooth muscle (ASM) cells are characterized by phenotypic plasticity and can switch between differentiated and proliferative phenotypes. In rabbit tracheal ASM cells that had been differentiated in vitro by serum ...

    • Expression of p53, p21/waf1, bcl-2, bax, Rb and Ki67 proteins in Hodgkin's lymphomas 

      Kanavaros, P.; Stefanaki, K.; Vlachonikolis, J.; Eliopoulos, C.; Kakolyris, S.; Rontogianni, D.; Gorgoulis, V.; Georgoulias, V. (2000)
      The aim was to investigate the combined immunoexpression of p53, p21, bcl-2, bax, Rb and Ki67 proteins in Hodgkin's lymphomas (HL) and correlate expression patterns with the histotype and the Epstein-Barr Virus (EBV) status. ...

    • The flavonoid quercetin induces hypoxia-inducible factor-1 alpha (HIF-1 alpha) and inhibits cell proliferation by depleting intracellular iron 

      Triantafyllou, A.; Liakos, P.; Tsakalof, A.; Chachami, G.; Paraskeva, E.; Molyvdas, P. A.; Georgatsou, E.; Simos, G.; Bonanou, S. (2007)
      Quercetin, a flavonoid with anti- oxidant, metal chelating, kinase modulating and anti- proliferative properties, can induce hypoxia- inducible factor-1 alpha (HIF-1 alpha) in normoxia, but its mechanism of action has not ...

    • Flavonoids induce HIF-1 alpha but impair its nuclear accumulation and activity 

      Triantafyllou, A.; Mylonis, L.; Simos, G.; Bonanou, S.; Tsakalof, A. (2008)
      Hypoxia-inducible factor-1 alpha (HIF-1 alpha) is the regulatory subunit of the transcription factor HIF-1, which is highly involved in the pathology of diseases associated with tissue hypoxia. In this study we investigated ...

    • Flow Cytometric Detection of p38 MAPK Phosphorylation and Intracellular Cytokine Expression in Peripheral Blood Subpopulations from Patients with Autoimmune Rheumatic Diseases 

      Mavropoulos, A.; Bogdanos, D. P.; Liaskos, C.; Orfanidou, T.; Simopoulou, T.; Zafiriou, E.; Sakkas, L. I.; Rigopoulou, E. I. (2014)
      Flow cytometric analysis of p38 mitogen-activated protein kinase (p38 MAPK) signaling cascade is optimally achieved by methanol permeabilization protocols. Such protocols suffer from the difficulties to accurately detect ...

    • Foxp3 expression in human cancer cells 

      Karanikas, V.; Speletas, M.; Zamanakou, M.; Kalala, F.; Loules, G.; Kerenidi, T.; Barda, A. K.; Gourgoulianis, K. I.; Germenis, A. E. (2008)
      Objective: Transcription factor forkhead box protein 3 (Foxp3) specifically characterizes the thymically derived naturally occurring regulatory T cells (Tregs). Limited evidence indicates that it is also expressed, albeit ...

    • Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture 

      Estrada, K.; Styrkarsdottir, U.; Evangelou, E.; Hsu, Y. H.; Duncan, E. L.; Ntzani, E. E.; Oei, L.; Albagha, O. M. E.; Amin, N.; Kemp, J. P.; Koller, D. L.; Li, G.; Liu, C. T.; Minster, R. L.; Moayyeri, A.; Vandenput, L.; Willner, D.; Xiao, S. M.; Yerges-Armstrong, L. M.; Zheng, H. F.; Alonso, N.; Eriksson, J.; Kammerer, C. M.; Kaptoge, S. K.; Leo, P. J.; Thorleifsson, G.; Wilson, S. G.; Wilson, J. F.; Aalto, V.; Alen, M.; Aragaki, A. K.; Aspelund, T.; Center, J. R.; Dailiana, Z.; Duggan, D. J.; Garcia, M.; Garcia-Giralt, N.; Giroux, S.; Hallmans, G.; Hocking, L. J.; Husted, L. B.; Jameson, K. A.; Khusainova, R.; Kim, G. S.; Kooperberg, C.; Koromila, T.; Kruk, M.; Laaksonen, M.; Lacroix, A. Z.; Lee, S. H.; Leung, P. C.; Lewis, J. R.; Masi, L.; Mencej-Bedrac, S.; Nguyen, T. V.; Nogues, X.; Patel, M. S.; Prezelj, J.; Rose, L. M.; Scollen, S.; Siggeirsdottir, K.; Smith, A. V.; Svensson, O.; Trompet, S.; Trummer, O.; van Schoor, N. M.; Woo, J.; Zhu, K.; Balcells, S.; Brandi, M. L.; Buckley, B. M.; Cheng, S. L.; Christiansen, C.; Cooper, C.; Dedoussis, G.; Ford, I.; Frost, M.; Goltzman, D.; Gonzalez-Macias, J.; Kahonen, M.; Karlsson, M.; Khusnutdinova, E.; Koh, J. M.; Kollia, P.; Langdahl, B. L.; Leslie, W. D.; Lips, P.; Ljunggren, O.; Lorenc, R. S.; Marc, J.; Mellstrom, D.; Obermayer-Pietsch, B.; Olmos, J. M.; Pettersson-Kymmer, U.; Reid, D. M.; Riancho, J. A.; Ridker, P. M.; Rousseau, F.; Slagboom, P. E.; Tang, N. L. S.; Urreizti, R.; Van Hul, W.; Viikari, J.; Zarrabeitia, M. T.; Aulchenko, Y. S.; Castano-Betancourt, M.; Grundberg, E.; Herrera, L.; Ingvarsson, T.; Johannsdottir, H.; Kwan, T.; Li, R.; Luben, R.; Medina-Gomez, C.; Palsson, S. T.; Reppe, S.; Rotter, J. I.; Sigurdsson, G.; van Meurs, J. B. J.; Verlaan, D.; Williams, F. M. K.; Wood, A. R.; Zhou, Y. H.; Gautvik, K. M.; Pastinen, T.; Raychaudhuri, S.; Cauley, J. A.; Chasman, D. I.; Clark, G. R.; Cummings, S. R.; Danoy, P.; Dennison, E. M.; Eastell, R.; Eisman, J. A.; Gudnason, V.; Hofman, A.; Jackson, R. D.; Jones, G.; Jukema, J. W.; Khaw, K. T.; Lehtimaki, T.; Liu, Y. M.; Lorentzon, M.; McCloskey, E.; Mitchell, B. D.; Nandakumar, K.; Nicholson, G. C.; Oostra, B. A.; Peacock, M.; Pols, H. A. P.; Prince, R. L.; Raitakari, O.; Reid, I. R.; Robbins, J.; Sambrook, P. N.; Sham, P. C.; Shuldiner, A. R.; Tylavsky, F. A.; van Duijn, C. M.; Wareham, N. J.; Cupples, L. A.; Econs, M. J.; Evans, D. M.; Harris, T. B.; Kung, A. W. C.; Psaty, B. M.; Reeve, J.; Spector, T. D.; Streeten, E. A.; Zillikens, M. C.; Thorsteinsdottir, U.; Ohlsson, C.; Karasik, D.; Richards, J. B.; Brown, M. A.; Stefansson, K.; Uitterlinden, A. G.; Ralston, S. H.; Ioannidis, J. P. A.; Kiel, D. P.; Rivadeneira, F. (2012)
      Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 ...

    • Genome-Wide Transcriptomic Analysis of Intestinal Tissue to Assess the Impact of Nutrition and a Secondary Nematode Challenge in Lactating Rats 

      Athanasiadou, S.; Jones, L. A.; Burgess, S. T. G.; Kyriazakis, I.; Pemberton, A. D.; Houdijk, J. G. M.; Huntley, J. F. (2011)
      Background: Gastrointestinal nematode infection is a major challenge to the health and welfare of mammals. Although mammals eventually acquire immunity to nematodes, this breaks down around parturition, which renders ...

    • HOW CAN BIOINFORMATICS AND TOXICOGENOMICS ASSIST THE NEXT GENERATION OF RESEARCH ON PHYSICAL EXERCISE AND ATHLETIC PERFORMANCE 

      Kerksick, C. M.; Tsatsakis, A. M.; Hayes, A. W.; Kafantaris, I.; Kouretas, D. (2015)
      The past 2-3 decades have seen an explosion in analytical areas related to "omic" technologies. These advancements have reached a point where their application can be and are being used as a part of exercise physiology and ...

    • Hypoxia causes triglyceride accumulation by HIF-1-mediated stimulation of lipin 1 expression 

      Mylonis, I.; Sembongi, H.; Befani, C.; Liakos, P.; Siniossoglou, S.; Simos, G. (2012)
      Adaptation to hypoxia involves hypoxia-inducible transcription factors (HIFs) and requires reprogramming of cellular metabolism that is essential during both physiological and pathological processes. In contrast to the ...

    • Hypoxia Inducible Factor-1alpha and Vascular Endothelial Growth Factor in Biopsies of Small Cell Lung Carcinoma 

      Ioannou, M.; Papamichali, R.; Kouvaras, E.; Mylonis, I.; Vageli, D.; Kerenidou, T.; Barbanis, S.; Daponte, A.; Simos, G.; Gourgoulianis, K.; Koukoulis, G. K. (2009)
      Neoangiogenesis has been documented in small cell lung carcinoma (SCLC). In addition, antiangiogenic therapies are being tested in clinical trials that involve SCLC. However, study of the underlying mechanisms has been ...

    • In vitro effects of endothelin-1 on the contractility of myometrium obtained from pre- and postmenopausal women 

      Domali, E.; Asprodini, E.; Molyvdas, P. A.; Messinis, I. E. (2001)
      This study was conducted to evaluate the responsiveness of human nonpregnant myometrium to endothelin 1 (ET1) (10(-10) M-10(-6) M) and KCl (80 mM) in relation to the hormonal profile of the women, who were allocated into ...

    • Intensity of Resistance Exercise Determines Adipokine and Resting Energy Expenditure Responses in Overweight Elderly Individuals 

      Fatouros, I. G.; Chatzinikolaou, A.; Tournis, S.; Nikolaidis, M. G.; Jamurtas, A. Z.; Douroudos, II; Papassotiriou, I.; Thomakos, P. M.; Taxildaris, K.; Mastorakos, G.; Mitrakou, A. (2009)
      OBJECTIVE - To evaluate the time course of leptin, adiponectin, and testing energy expenditure (REE) responses in overweight elderly mates after acute resistance exercise protocols of various intensity configurations. ...

    • Intramuscular responses with muscle damaging exercise and the interplay between multiple intracellular networks: A human perspective 

      Kerksick, C. M.; Willoughby, D.; Kouretas, D.; Tsatsakis, A. (2013)
      Damaging exercise invokes a series of widespread changes that impact many aspects of skeletal muscle physiology. When examining candidate intramuscular mechanisms, those associated with oxidative stress, inflammation, ...

    • Isolation of hypoxia-inducible factor 1 (HIF-1) inhibitors from frankincense using a molecularly imprinted polymer 

      Lakka, A.; Mylonis, I.; Bonanou, S.; Simos, G.; Tsakalof, A. (2011)
      Hypoxia-Inducible Factor 1 (HIF-1), a transcriptional activator, is highly involved in the pathology of cancer. Inhibition of HIF-1 retards tumor growth and enhances treatment efficiency when used in combination with chemo- ...

    • Leptin and adiponectin responses in overweight inactive elderly following resistance training and detraining are intensity related 

      Fatouros, I. G.; Tournis, S.; Leontsini, D.; Jamurtas, A. Z.; Sxina, M.; Thomakos, P.; Manousaki, M.; Douroudos, I.; Taxildaris, K.; Mitrakou, A. (2005)
      Context: Adiponectin and leptin are closely related to weight control and energy balance, whereas exercise affects elderly metabolic regulation and functional capacity. Objective: The objective of this study was to investigate ...

    • Low Oxygen Tension Enhances Hepatitis C Virus Replication 

      Vassilaki, N.; Kalliampakou, K. I.; Kotta-Loizou, I.; Befani, C.; Liakos, P.; Simos, G.; Mentis, A. F.; Kalliaropoulos, A.; Doumba, P. P.; Smirlis, D.; Foka, P.; Bauhofer, O.; Poenisch, M.; Windisch, M. P.; Lee, M. E.; Koskinas, J.; Bartenschlager, R.; Mavromara, P. (2013)
      Low oxygen tension exerts a significant effect on the replication of several DNA and RNA viruses in cultured cells. In vitro propagation of hepatitis C virus (HCV) has thus far been studied under atmospheric oxygen levels ...

    • Low Serum Hepcidin in Patients with Autoimmune Liver Diseases 

      Lyberopoulou, A.; Chachami, G.; Gatselis, N. K.; Kyratzopoulou, E.; Saitis, A.; Gabeta, S.; Eliades, P.; Paraskeva, E.; Zachou, K.; Koukoulis, G. K.; Mamalaki, A.; Dalekos, G. N.; Simos, G. (2015)
      Hepcidin, a liver hormone, is important for both innate immunity and iron metabolism regulation. As dysfunction of the hepcidin pathway may contribute to liver pathology, we analysed liver hepcidin mRNA and serum hepcidin ...