Πλοήγηση ανά Θέμα "Flavonoids"
Αποτελέσματα 21-24 από 24
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Sourcing the affinity of flavonoids for the glycogen phosphorylase inhibitor site via crystallography, kinetics and QM/MM-PBSA binding studies: Comparison of chrysin and flavopiridol
(2013)Flavonoids have been discovered as novel inhibitors of glycogen phosphorylase (GP), a target to control hyperglycemia in type 2 diabetes. To elucidate the mechanism of inhibition, we have determined the crystal structure ... -
Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors
(2020)Glycogen phosphorylase (GP) is an important target for the development of new anti-hyperglycaemic agents. Flavonoids are novel inhibitors of GP, but their mode of action is unspecific in terms of the GP binding sites ... -
Thermochemical Transition in Low Molecular Weight Substances: The Example of the Silybin Flavonoid
(2022)Silybin is a complex organic molecule with high bioactivity, extracted from the plant Silybum. As a pharmaceutical substance, silybin’s bioactivity has drawn considerable attention, while its other properties, e.g., ... -
Yield and silymarin content in milk thistle (Silybum marianum (L.) Gaertn.) fruits affected by the nitrogen fertilizers
(2021)Milk thistle (Silybum marianum (L.) Gaertn.) is a common weed that has been introduced as a medicinal plant for silymarin production. This renders it important to optimize cultivation techniques, including fertilization. ...