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    • AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders 

      Salpietro V., Dixon C.L., Guo H., Bello O.D., Vandrovcova J., Efthymiou S., Maroofian R., Heimer G., Burglen L., Valence S., Torti E., Hacke M., Rankin J., Tariq H., Colin E., Procaccio V., Striano P., Mankad K., Lieb A., Chen S., Pisani L., Bettencourt C., Männikkö R., Manole A., Brusco A., Grosso E., Ferrero G.B., Armstrong-Moron J., Gueden S., Bar-Yosef O., Tzadok M., Monaghan K.G., Santiago-Sim T., Person R.E., Cho M.T., Willaert R., Yoo Y., Chae J.-H., Quan Y., Wu H., Wang T., Bernier R.A., Xia K., Blesson A., Jain M., Motazacker M.M., Jaeger B., Schneider A.L., Boysen K., Muir A.M., Myers C.T., Gavrilova R.H., Gunderson L., Schultz-Rogers L., Klee E.W., Dyment D., Osmond M., Parellada M., Llorente C., Gonzalez-Peñas J., Carracedo A., Van Haeringen A., Ruivenkamp C., Nava C., Heron D., Nardello R., Iacomino M., Minetti C., Skabar A., Fabretto A., Hanna M.G., Bugiardini E., Hostettler I., O’Callaghan B., Khan A., Cortese A., O’Connor E., Yau W.Y., Bourinaris T., Kaiyrzhanov R., Chelban V., Madej M., Diana M.C., Vari M.S., Pedemonte M., Bruno C., Balagura G., Scala M., Fiorillo C., Nobili L., Malintan N.T., Zanetti M.N., Krishnakumar S.S., Lignani G., Jepson J.E.C., Broda P., Baldassari S., Rossi P., Fruscione F., Madia F., Traverso M., De-Marco P., Pérez-Dueñas B., Munell F., Kriouile Y., El-Khorassani M., Karashova B., Avdjieva D., Kathom H., Tincheva R., Van-Maldergem L., Nachbauer W., Boesch S., Gagliano A., Amadori E., Goraya J.S., Sultan T., Kirmani S., Ibrahim S., Jan F., Mine J., Banu S., Veggiotti P., Zuccotti G.V., Ferrari M.D., Van Den Maagdenberg A.M.J., Verrotti A., Marseglia G.L., Savasta S., Soler M.A., Scuderi C., Borgione E., Chimenz R., Gitto E., Dipasquale V., Sallemi A., Fusco M., Cuppari C., Cutrupi M.C., Ruggieri M., Cama A., Capra V., Mencacci N.E., Boles R., Gupta N., Kabra M., Papacostas S., Zamba-Papanicolaou E., Dardiotis E., Maqbool S., Rana N., Atawneh O., Lim S.Y., Shaikh F., Koutsis G., Breza M., Coviello D.A., Dauvilliers Y.A., AlKhawaja I., AlKhawaja M., Al-Mutairi F., Stojkovic T., Ferrucci V., Zollo M., Alkuraya F.S., Kinali M., Sherifa H., Benrhouma H., Turki I.B.Y., Tazir M., Obeid M., Bakhtadze S., Saadi N.W., Zaki M.S., Triki C.C., Benfenati F., Gustincich S., Kara M., Belcastro V., Specchio N., Capovilla G., Karimiani E.G., Salih A.M., Okubadejo N.U., Ojo O.O., Oshinaike O.O., Oguntunde O., Wahab K., Bello A.H., Abubakar S., Obiabo Y., Nwazor E., Ekenze O., Williams U., Iyagba A., Taiwo L., Komolafe M., Senkevich K., Shashkin C., Zharkynbekova N., Koneyev K., Manizha G., Isrofilov M., Guliyeva U., Salayev K., Khachatryan S., Rossi S., Silvestri G., Haridy N., Ramenghi L.A., Xiromerisiou G., David E., Aguennouz M., Fidani L., Spanaki C., Tucci A., Raspall-Chaure M., Chez M., Tsai A., Fassi E., Shinawi M., Constantino J.N., De Zorzi R., Fortuna S., Kok F., Keren B., Bonneau D., Choi M., Benzeev B., Zara F., Mefford H.C., Scheffer I.E., Clayton-Smith J., Macaya A., Rothman J.E., Eichler E.E., Kullmann D.M., Houlden H., SYNAPS Study Group (2019)
      AMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations of GluA1-4 subunits encoded by GRIA1-4 genes. GluA2 has an especially important role because, following post-transcriptional editing at ...

    • AMY1 diploid copy number among end-stage renal disease patients 

      Grammatikopoulou M.G., Gkiouras K., Markaki A.G., Gkouskou K.K., Aivaliotis M., Stylianou K., Bogdanos D.P. (2020)
      Purpose: The salivary amylase gene (AMY1) copy number variation (CNV) is increased as a human adaptation to starch-enriched nutritional patterns. The purpose of this study was to evaluate the relationship between AMY1 CNV, ...

    • Anatomical variations of the foramen transversarium in cervical vertebrae: findings, review of the literature, and clinical significance during cervical spine surgery 

      Zibis A.H., Mitrousias V., Baxevanidou K., Hantes M., Karachalios T., Arvanitis D. (2016)
      Purpose: To describe certain anatomical variations of the foramen transversarium, in spine cervical vertebrae in a contemporary specimen of an Indo-European population and approach their clinical importance during cervical ...

    • Anti-C1q autoantibodies are frequently detected in patients with systemic sclerosis associated with pulmonary fibrosis 

      Liaskos C., Rentouli S., Simopoulou T., Gkoutzourelas A., Norman G.L., Brotis A., Alexiou I., Katsiari C., Bogdanos D.P., Sakkas L.I. (2019)
      Background: Anti-C1q autoantibodies (autoAbs) are associated with systemic lupus erythematosus (SLE), but their presence in other rheumatic diseases has not been adequately investigated. Objectives: We aimed to assess ...

    • Anti-hsp60 antibody responses based on Helicobacter pylori in patients with multiple sclerosis: (ir)Relevance to disease pathogenesis 

      Efthymiou G., Dardiotis E., Liaskos C., Marou E., Tsimourtou V., Scheper T., Meyer W., Daponte A., Sakkas L.I., Hadjigeorgiou G., Bogdanos D.P. (2016)
      In view of published data suggesting that Helicobacter pylori (Hp) is a trigger of multiple sclerosis (MS), we assessed anti-heat shock protein 60 (hsp60)Hp antibody reactivity in 129 MS patients and 48 demograpically-matched ...

    • Anti-MCV antibodies predict radiographic progression in Greek patients with very early (<3 months duration) rheumatoid arthritis 

      Barouta G., Katsiari C.G., Alexiou I., Liaskos C., Varna A., Bogdanos D.P., Germenis A.E., Sakkas L.I. (2017)
      This study aimed to assess the diagnostic and prognostic value of anti-mutated citrullinated vimentin (MCV) antibodies in very early rheumatoid arthritis (VERA) and in established rheumatoid arthritis (RA). Seventy-one ...

    • Anti-Ro60 Seropositivity Determines Anti-Ro52 Epitope Mapping in Patients With Systemic Sclerosis 

      Gkoutzourelas A., Liaskos C., Mytilinaiou M.G., Simopoulou T., Katsiari C., Tsirogianni A., Daoussis D., Scheper T., Meyer W., Bogdanos D.P., Sakkas L.I. (2018)
      Epitope mapping of anti-Ro52 antibodies (Abs) has been extensively studied in patients with Sjögren's syndrome (SjS) and systemic lupus erythematosus (SLE). Comprehensive epitope mapping in systemic sclerosis (SSc), where ...

    • Antibody titers after a third dose of the SARS-CoV-2 BNT162b2 vaccine in immunocompromised adults in Greece: Is a fourth dose necessary? 

      Kontopoulou K., Nakas C.T., Belai C., Papazisis G. (2022)
      Real-world data suggest that protection against COVID-19 declines a few months after vaccination, particularly in the elderly and immunocompromised individuals. Our study aimed to analyze the humoral response induced by a ...

    • Antigen-specific humoral responses against Helicobacter pylori in patients with systemic sclerosis 

      Efthymiou G., Liaskos C., Simopoulou T., Marou E., Patrikiou E., Scheper T., Meyer W., Daoussis D., Sakkas L.I., Bogdanos D.P. (2020)
      Helicobacter pylori (Hp) is a likely trigger of systemic sclerosis (SSc), but systemic antigen-specific antibody (Ab) responses in a well-defined cohort of SSc patients have not been thoroughly assessed. Line immunoassay ...

    • Antioxidant responses following active and passive smoking of tobacco and electronic cigarettes 

      Poulianiti K., Karatzaferi C., Flouris A.D., Fatouros I.G., Koutedakis Y., Jamurtas A.Z. (2016)
      Context: It has been indicated that acute active and passive tobacco cigarette smoking may cause changes on redox status balance that may result in significant pathologies. However, no study has evaluated the effects of ...

    • Antipsychotic dose reduction compared to dose continuation for people with schizophrenia 

      Rodolico A., Siafis S., Bighelli I., Samara M.T., Hansen W.-P., Salomone S., Aguglia E., Cutrufelli P., Bauer I., Baeckers L., Leucht S. (2022)
      Background: Antipsychotic drugs are the mainstay treatment for schizophrenia, yet they are associated with diverse and potentially dose-related side effects which can reduce quality of life. For this reason, the lowest ...

    • Antipsychotic polypharmacy reduction versus polypharmacy continuation for people with schizophrenia 

      Bighelli I., Rodolico A., Siafis S., Samara M.T., Hansen W.-P., Salomone S., Aguglia E., Cutrufelli P., Bauer I., Baeckers L., Leucht S. (2022)
      Background: In clinical practice, different antipsychotics can be combined in the treatment of people with schizophrenia (polypharmacy). This strategy can aim at increasing efficacy, but might also increase the adverse ...

    • Apocrine and eccrine hidrocystomas: A clinicopathological study 

      Koumaki D., Papadakis M., Lagoudaki E., Manios G.A., Kassotakis D., Doxastaki A., Krasagakis K., Manios A. (2021)
      Introduction: Eccrine and apocrine hidrocystomas are uncommon, benign, cystic proliferations of the sweat glands usually located on the head and neck area. Objectives: To describe the key clinical and histopathological ...

    • Apolipoprotein E Polymorphism and Left Ventricular Failure in Beta-Thalassemia: A Multivariate Meta-Analysis 

      Dimou N.L., Pantavou K.G., Bagos P.G. (2017)
      Apolipoprotein E (ApoE) is potentially a genetic risk factor for the development of left ventricular failure (LVF), the main cause of death in beta-thalassemia homozygotes. In the present study, we synthesize the results ...

    • Appetite control across the lifecourse: The acute impact of breakfast drink quantity and protein content. the full4health project 

      Crabtree D.R., Buosi W., Fyfe C.L., Horgan G.W., Manios Y., Androutsos O., Giannopoulou A., Finlayson G., Beaulieu K., Meek C.L., Holst J.J., Van Norren K., Mercer J.G., Johnstone A.M., Full4Health-Study Group (2020)
      Understanding the mechanisms of hunger, satiety and how nutrients affect appetite control is important for successful weight management across the lifecourse. The primary aim of this study was to describe acute appetite ...

    • Apremilast increases IL-10-producing regulatory B cells and decreases proinflammatory T cells and innate cells in psoriatic arthritis and psoriasis 

      Mavropoulos A., Zafiriou E., Simopoulou T., Brotis A.G., Liaskos C., Roussaki-Schulze A., Katsiari C.G., Bogdanos D.P., Sakkas L.I. (2019)
      Objectives: Psoriatic arthritis (PsA) and psoriasis are immune-mediated inflammatory diseases sharing common immunological mechanisms. Regulatory B cells (Breg cells) producing IL-10 (B10 cells), a critical anti-inflammatory ...

    • Are municipal solid waste collectors at increased risk of Hepatitis A Virus infection? A Greek cross-sectional study 

      Rachiotis G., Tsovili E., Papagiannis D., Markaki A., Hadjichristodoulou C. (2016)
      Municipal solid waste collectors are reportedly at risk for Hepatitis A virus infection (HAV) as an occupational hazard. We aimed to investigate the prevalence and possible risk factors of HAV infection among solid waste ...

    • Are younger COPD patients adequately vaccinated for influenza and pneumococcus? 

      Gogou E., Hatzoglou C., Zarogiannis S.G., Siachpazidou D., Gerogianni I., Kotsiou O.S., Varsamas C., Gourgoulianis K.I. (2022)
      Influenza and pneumococcal pneumonia are major causes of increased morbidity and mortality among elderly and COPD patients. Vaccines against influenza and pneumococcus are recommended for COPD patients according to GOLD ...

    • Arthroscopic Single-Row Versus Double-Row Suture Bridge Technique for Rotator Cuff Tears in Patients Younger Than 55 Years: A Prospective Comparative Study 

      Hantes M.E., Ono Y., Raoulis V.A., Doxariotis N., Venouziou A., Zibis A., Vlychou M. (2018)
      Background: When arthroscopic rotator cuff repair is performed on a young patient, long-lasting structural and functional tendon integrity is desired. A fixation technique that potentially provides superior tendon healing ...

    • Assessing multiple-group diagnostic problems with multi-dimensional receiver operating characteristic surfaces: Application to proton MR Spectroscopy (MRS) in HIV-related neurological injury 

      Yiannoutsos, C. T.; Nakas, C. T.; Navia, B. A.; Proton, M. R. S. Consortium (2008)
      We present the multi-dimensional Receiver Operating Characteristic (ROC) surface, a plot of the true classification rates of tests based on levels of biological markers, for multi-group discrimination, as an extension of ...