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Πλοήγηση ανά Συγγραφέα "Gonzalez, A."

Αποτελέσματα 21-30 από 30

    • A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5 ' UTR of GDF5 with osteoarthritis susceptibility 

      Chapman, K.; Takahashi, A.; Meulenbelt, I.; Watson, C.; Rodriguez-Lopez, J.; Egli, R.; Tsezou, A.; Malizos, K. N.; Kloppenburg, M.; Shi, D. Q.; Southam, L.; van der Breggen, R.; Donn, R.; Qin, J. H.; Doherty, M.; Slagboom, P. E.; Wallis, G.; Kamatani, N.; Jiang, Q.; Gonzalez, A.; Loughlin, J.; Ikegawa, S. (2008)
      We have performed a meta-analysis combining data for more than 11 000 individuals. It provides compelling evidence for a positive association between a functional single-nucleotide polymorphism (SNP) in the 5'-UTR of GDF5 ...

    • Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22 

      Evangelou, E.; Valdes, A. M.; Kerkhof, H. J. M.; Styrkarsdottir, U.; Zhu, Y.; Meulenbelt, I.; Lories, R. J.; Karassa, F. B.; Tylzanowski, P.; Bos, S. D.; Rayner, N. W.; Southam, L.; Zhai, G.; Elliott, K. S.; Hunt, S. E.; Blackburn, H.; Potter, S. C.; Day-Williams, A. G.; Beazley, C.; Akune, T.; Arden, N. K.; Carr, A.; Chapman, K.; Cupples, L. A.; Dai, J.; Deloukas, P.; Doherty, M.; Doherty, S.; Engstrom, G.; Gonzalez, A.; Halldorsson, B. V.; Hammond, C. L.; Hart, D. J.; Helgadottir, H.; Hofman, A.; Ikegawa, S.; Ingvarsson, T.; Jiang, Q.; Jonsson, H.; Kaprio, J.; Kawaguchi, H.; Kisand, K.; Kloppenburg, M.; Kujala, U. M.; Lohmander, L. S.; Loughlin, J.; Luyten, F. P.; Mabuchi, A.; McCaskie, A.; Nakajima, M.; Nilsson, P. M.; Nishida, N.; Ollier, W. E. R.; Panoutsopoulou, K.; Van De Putte, T.; Ralston, S. H.; Rivadeneira, F.; Saarela, J.; Schulte-Merker, S.; Shi, D.; Slagboom, P. E.; Sudo, A.; Tamm, A.; Thorleifsson, G.; Thorsteinsdottir, U.; Tsezou, A.; Wallis, G. A.; Wilkinson, J. M.; Yoshimura, N.; Zeggini, E.; Zhang, F.; Jonsdottir, I.; Uitterlinden, A. G.; Felson, D. T.; Van Meurs, J. B.; Stefansson, K.; Ioannidis, J. P. A.; Spector, T. D. (2011)
      Objectives: Osteoarthritis (OA) is the most prevalent form of arthritis and accounts for substantial morbidity and disability, particularly in older people. It is characterised by changes in joint structure, including ...

    • A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip 

      Evangelou, E.; Kerkhof, H. J.; Styrkarsdottir, U.; Ntzani, E. E.; Bos, S. D.; Esko, T.; Evans, D. S.; Metrustry, S.; Panoutsopoulou, K.; Ramos, Y. F. M.; Thorleifsson, G.; Tsilidis, K. K.; Arden, N.; Aslam, N.; Bellamy, N.; Birrell, F.; Blanco, F. J.; Carr, A.; Chapman, K.; Day-Williams, A. G.; Deloukas, P.; Doherty, M.; Engstrom, G.; Helgadottir, H. T.; Hofman, A.; Ingvarsson, T.; Jonsson, H.; Keis, A.; Keurentjes, J. C.; Kloppenburg, M.; Lind, P. A.; McCaskie, A.; Martin, N. G.; Milani, L.; Montgomery, G. W.; Nelissen, Rghh; Nevitt, M. C.; Nilsson, P. M.; Ollier, W. E. R.; Parimi, N.; Rai, A.; Ralston, S. H.; Reed, M. R.; Riancho, J. A.; Rivadeneira, F.; Rodriguez-Fontenla, C.; Southam, L.; Thorsteinsdottir, U.; Tsezou, A.; Awallis, G.; Wilkinson, J. M.; Gonzalez, A.; Lane, N. E.; Lohmander, L. S.; Loughlin, J.; Metspalu, A.; Uitterlinden, A. G.; Jonsdottir, I.; Stefansson, K.; Slagboom, P. E.; Zeggini, E.; Meulenbelt, I.; Ioannidis, J. P. A.; Spector, T. D.; van Meurs, J. B. J.; Valdes, A. M.; arc, Ogen Consortium (2014)
      Objectives Osteoarthritis (OA) is the most common form of arthritis with a clear genetic component. To identify novel loci associated with hip OA we performed a meta-analysis of genome-wide association studies (GWAS) on ...

    • NEW FUNCTIONAL MICROSATELLITE ASSOCIATED WITH OSTEOARTHRITIS SUSCEPTIBILITY 

      Vidal-Bralo, L.; Rodriguez-Fontela, C.; Calaza, M.; Oreiro, N.; Blanco, F. J.; Carr, A.; Odriozola, A.; Riancho, J.; Gomez-Reino, J. J.; Tsezou, A.; Loughlin, J.; Gonzalez, A.; arc, Ogen Consortium (2014)

    • New Sequence Variants in HLA Class II/III Region Associated with Susceptibility to Knee Osteoarthritis Identified by Genome-Wide Association Study 

      Nakajima, M.; Takahashi, A.; Kou, I.; Rodriguez-Fontenla, C.; Gomez-Reino, J. J.; Furuichi, T.; Dai, J.; Sudo, A.; Uchida, A.; Fukui, N.; Kubo, M.; Kamatani, N.; Tsunoda, T.; Malizos, K. N.; Tsezou, A.; Gonzalez, A.; Nakamura, Y.; Ikegawa, S. (2010)
      Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through ...

    • Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium 

      Kerkhof, H. J. M.; Meulenbelt, I.; Akune, T.; Arden, N. K.; Aromaa, A.; Bierma-Zeinstra, S. M. A.; Carr, A.; Cooper, C.; Dai, J.; Doherty, M.; Doherty, S. A.; Felson, D.; Gonzalez, A.; Gordon, A.; Harilainen, A.; Hart, D. J.; Hauksson, V. B.; Heliovaara, M.; Hofman, A.; Ikegawa, S.; Ingvarsson, T.; Jiang, Q.; Jonsson, H.; Jonsdottir, I.; Kawaguchi, H.; Kloppenburg, M.; Kujala, U. M.; Lane, N. E.; Leino-Arjas, P.; Lohmander, L. S.; Luyten, F. P.; Malizos, K. N.; Nakajima, M.; Nevitt, M. C.; Pols, H. A. P.; Rivadeneira, F.; Shi, D.; Slagboom, E.; Spector, T. D.; Stefansson, K.; Sudo, A.; Tamm, A.; Tamm, A. E.; Tsezou, A.; Uchida, A.; Uitterlinden, A. G.; Wilkinson, J. M.; Yoshimura, N.; Valdes, A. M.; van Meurs, J. B. J. (2011)
      Objective: To address the need for standardization of osteoarthritis (OA) phenotypes by examining the effect of heterogeneity among symptomatic (SOA) and radiographic osteoarthritis (ROA) phenotypes. Methods: Descriptions ...

    • RECOMMENDATIONS FOR STANDARDIZATION AND PHENOTYPE DEFINITIONS IN GENETIC STUDIES OF OSTEOARTHRITIS: THE TREAT-OA CONSORTIUM 

      Kerkhof, H. J.; Meulenbelt, I.; Arden, N.; Cooper, C.; Doherty, M.; Felson, D.; Gonzalez, A.; Ikegawa, S.; Jiang, Q.; Jonsdottir, I.; Kujala, U.; Lane, N.; Leino-Arjas, P.; Lohmander, S.; Luyten, F.; Nevitt, M.; Slagboom, E.; Spector, T.; Stefansson, K.; Tamm, A.; Tsezou, A.; Wilkinson, J.; Yoshimura, N.; Valdes, A.; van Meurs, J. (2010)

    • REDUCED CLINICAL IMPROVEMENT IN RHEUMATOID ARTHRITIS PATIENTS SHOWING IGG1 ALLOTYPE -INFLIXIMAB INCOMPATIBILITY 

      Montes, A.; Perez-Pampin, E.; Navarro-Sarabia, F.; Moreira, V.; de la Serna, A. R.; Magallanes, B.; Vasilopoulos, Y.; Sarafidou, T.; Fernandez-Nebro, A.; Ordonez, M. D. C.; Narvaez, J.; Canete, J. D.; Isaacs, J.; Morgan, A.; Barton, A.; Wilson, A. G.; Gomez-Reino, J. J.; Gonzalez, A.; Bragggss (2013)

    • Rheumatoid arthritis response to treatment across IgG1 allotype - anti-TNF incompatibility: a case-only study 

      Montes, A.; Perez-Pampin, E.; Navarro-Sarabia, F.; Moreira, V.; de la Sema, A. R.; Magallares, B.; Vasilopoulos, Y.; Sarafidou, T.; Fernandez-Nebro, A.; Ordonez, M. D.; Narvaez, J.; Canete, J. D.; Marquez, A.; Pascual-Salcedo, D.; Joven, B.; Carreira, P.; Moreno-Ramos, M. J.; Caliz, R.; Ferrer, M. A.; Garcia-Portales, R.; Blanco, F. J.; Magro, C.; Raya, E.; Valor, L.; Alegre-Sancho, J. J.; Balsa, A.; Martin, J.; Plant, D.; Isaacs, J.; Morgan, A. W.; Barton, A.; Wilson, A. G.; Gomez-Reino, J. J.; Gonzalez, A.; Braggss (2015)
      Introduction: We have hypothesized that incompatibility between the G1m genotype of the patient and the G1m1 and G1m17 allotypes carried by infliximab (INX) and adalimumab (ADM) could decrease the efficacy of these anti-tumor ...

    • Testing the druggable endothelial differentiation gene 2 knee osteoarthritis genetic factor for replication in a wide range of sample collections 

      Dieguez-Gonzalez, R.; Calaza, M.; Shi, D.; Meulenbelt, I.; Loughlin, J.; Tsezou, A.; Dai, J.; Malizos, K. N.; Slagboom, E. P.; Kloppenburg, M.; Chapman, K.; Jiang, Q.; Kremer, D.; Gomez-Reino, J. J.; Nakajima, N.; Ikegawa, S.; Gonzalez, A. (2009)
      Objectives: To replicate a previously reported association with osteoarthritis (OA) of the promoter single nucleotide polymorphism (SNP) rs10980705 in the endothelial differentiation gene 2 (EDG2). Methods: Five collections ...