dc.creator | Xenoulis P.G., Heilmann R.M., Stavroulaki E.M., Riggers D.S., Gneipel L.J., Suchodolski J.S., Steiner J.M. | en |
dc.date.accessioned | 2023-01-31T11:37:38Z | |
dc.date.available | 2023-01-31T11:37:38Z | |
dc.date.issued | 2022 | |
dc.identifier | 10.1111/jvim.16418 | |
dc.identifier.issn | 08916640 | |
dc.identifier.uri | http://hdl.handle.net/11615/80841 | |
dc.description.abstract | Background: Miniature Schnauzers (MS) commonly have idiopathic hypertriglyceridemia (HTGL), which is associated with insulin resistance (IR) and a subclinical inflammatory phenotype. Objectives: Determine the association between indicators of IR and inflammatory biomarkers in MS with and without HTGL and identify how indicators of IR are affected by dietary intervention in MS with HTGL. Animals: Seventy MS with HTGL and 79 MS without HTGL. In addition, 15 MS with HTGL were placed on a low-fat diet. Methods: Serum concentrations of triglycerides, cholesterol, calprotectin, insulin, and glucose were compared between groups. Results: Serum glucose and calprotectin concentrations (shown to be higher in MS with HTGL than in MS without HTGL) were inversely correlated (ρ = −.28; P <.001). After dietary intervention, median serum insulin concentrations were 8.1 mU/L compared to 20.8 mU/L before dietary intervention (P =.06). Dogs with complete resolution of HTGL after dietary intervention (5 dogs) had significantly lower serum insulin concentrations compared to baseline (P =.03). Conclusion and Clinical Importance: The subclinical inflammatory phenotype in MS with HTGL appears to be associated with IR. Resolution of HTGL by dietary intervention is associated with a decrease in serum insulin concentrations. The implication of the increase in serum calprotectin concentrations after resolution of HTGL warrants further study. © 2022 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine. | en |
dc.language.iso | en | en |
dc.source | Journal of Veterinary Internal Medicine | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85128565343&doi=10.1111%2fjvim.16418&partnerID=40&md5=6c03fdac9b560304d1b0150af3cea382 | |
dc.subject | biological marker | en |
dc.subject | C reactive protein | en |
dc.subject | calgranulin | en |
dc.subject | cholesterol | en |
dc.subject | glucose | en |
dc.subject | high density lipoprotein cholesterol | en |
dc.subject | hydrocortisone | en |
dc.subject | insulin | en |
dc.subject | low density lipoprotein cholesterol | en |
dc.subject | thyrotropin | en |
dc.subject | thyroxine | en |
dc.subject | triacylglycerol | en |
dc.subject | triacylglycerol lipase | en |
dc.subject | C reactive protein | en |
dc.subject | calgranulin | en |
dc.subject | glucose | en |
dc.subject | insulin derivative | en |
dc.subject | adult | en |
dc.subject | animal experiment | en |
dc.subject | animal model | en |
dc.subject | Article | en |
dc.subject | blood analysis | en |
dc.subject | blood biochemistry | en |
dc.subject | body condition score | en |
dc.subject | body weight | en |
dc.subject | centrifugation | en |
dc.subject | clinical evaluation | en |
dc.subject | controlled study | en |
dc.subject | correlation analysis | en |
dc.subject | diabetes mellitus | en |
dc.subject | diet therapy | en |
dc.subject | disease association | en |
dc.subject | disease severity assessment | en |
dc.subject | echography | en |
dc.subject | enzymatic assay | en |
dc.subject | equilibrium dialysis | en |
dc.subject | fat content | en |
dc.subject | feeding | en |
dc.subject | female | en |
dc.subject | free thyroxine index | en |
dc.subject | homeostasis model assessment | en |
dc.subject | hyperlipidemia | en |
dc.subject | idiopathic hyperlipidemia | en |
dc.subject | immunometric assay | en |
dc.subject | immunoreactivity | en |
dc.subject | inflammation | en |
dc.subject | innate immunity | en |
dc.subject | insulin resistance | en |
dc.subject | insulin tolerance test | en |
dc.subject | intervention study | en |
dc.subject | lipid diet | en |
dc.subject | lipid metabolism | en |
dc.subject | low fat diet | en |
dc.subject | male | en |
dc.subject | metabolic activation | en |
dc.subject | nonhuman | en |
dc.subject | pancreatitis | en |
dc.subject | radioimmunoassay | en |
dc.subject | sandwich immunoassay | en |
dc.subject | schnauzer | en |
dc.subject | thyrotropin blood level | en |
dc.subject | urinalysis | en |
dc.subject | animal | en |
dc.subject | dog | en |
dc.subject | dog disease | en |
dc.subject | hyperlipidemia | en |
dc.subject | hypertriglyceridemia | en |
dc.subject | insulin resistance | en |
dc.subject | low fat diet | en |
dc.subject | veterinary medicine | en |
dc.subject | Animals | en |
dc.subject | C-Reactive Protein | en |
dc.subject | Diet, Fat-Restricted | en |
dc.subject | Dog Diseases | en |
dc.subject | Dogs | en |
dc.subject | Glucose | en |
dc.subject | Hyperlipidemias | en |
dc.subject | Hypertriglyceridemia | en |
dc.subject | Insulin Resistance | en |
dc.subject | Insulins | en |
dc.subject | Leukocyte L1 Antigen Complex | en |
dc.subject | John Wiley and Sons Inc | en |
dc.title | Associations among serum insulin, calprotectin, and C-reactive protein concentrations in Miniature Schnauzers with idiopathic hyperlipidemia before and after feeding an ultra-low-fat diet | en |
dc.type | journalArticle | en |