dc.creator | Vlachos I.S., Vergoulis T., Paraskevopoulou M.D., Lykokanellos F., Georgakilas G., Georgiou P., Chatzopoulos S., Karagkouni D., Christodoulou F., Dalamagas T., Hatzigeorgiou A.G. | en |
dc.date.accessioned | 2023-01-31T11:36:56Z | |
dc.date.available | 2023-01-31T11:36:56Z | |
dc.date.issued | 2016 | |
dc.identifier | 10.1093/NAR/GKW455 | |
dc.identifier.issn | 03051048 | |
dc.identifier.uri | http://hdl.handle.net/11615/80654 | |
dc.description.abstract | Differential expression analysis (DEA) is one of the main instruments utilized for revealing molecular mechanisms in pathological and physiological conditions. DIANA-mirExTra v2.0 (http://www.microrna. gr/mirextrav2) performs a combined DEA of mRNAs and microRNAs (miRNAs) to uncover miRNAs and transcription factors (TFs) playing important regulatory roles between two investigated states. The web server uses as input miRNA/RNA-Seq read count data sets that can be uploaded for analysis. Users can combine their data with 350 small-RNA-Seq and 65 RNA-Seq in-house analyzed libraries which are provided by DIANA-mirExTra v2.0. The web server utilizes miRNA:mRNA, TF:mRNA and TF:miRNA interactions derived from extensive experimental data sets. More than 450 000 miRNA interactions and 2 000 000 TF binding sites from specific or high-throughput techniques have been incorporated, while accurate miRNA TSS annotation is obtained from microTSS experimental/in silico framework. These comprehensive data sets enable users to perform analyses based solely on experimentally supported information and to uncover central regulators within sequencing data: miRNAs controlling mRNAs and TFs regulating mRNA or miRNA expression. The server also supports predicted miRNA:gene interactions from DIANA-microT-CDS for 4 species (human, mouse, nematode and fruit fly). DIANA-mirExTra v2.0 has an intuitive user interface and is freely available to all users without any login requirement. © The Author(s) 2016. | en |
dc.language.iso | en | en |
dc.source | Nucleic Acids Research | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85012935580&doi=10.1093%2fNAR%2fGKW455&partnerID=40&md5=da603960877d8e4c59dd128f3a51162f | |
dc.subject | messenger RNA | en |
dc.subject | microRNA | en |
dc.subject | RNA | en |
dc.subject | transcription factor | en |
dc.subject | messenger RNA | en |
dc.subject | microRNA | en |
dc.subject | protein binding | en |
dc.subject | transcription factor | en |
dc.subject | Article | en |
dc.subject | binding site | en |
dc.subject | bioinformatics | en |
dc.subject | computer model | en |
dc.subject | controlled study | en |
dc.subject | data analysis | en |
dc.subject | differential expression analysis | en |
dc.subject | Drosophila | en |
dc.subject | gene expression regulation | en |
dc.subject | gene function | en |
dc.subject | gene interaction | en |
dc.subject | high throughput sequencing | en |
dc.subject | human | en |
dc.subject | mouse | en |
dc.subject | nematode | en |
dc.subject | nonhuman | en |
dc.subject | protein function | en |
dc.subject | protein RNA binding | en |
dc.subject | RNA analysis | en |
dc.subject | RNA sequencing | en |
dc.subject | statistical analysis | en |
dc.subject | transcription initiation site | en |
dc.subject | animal | en |
dc.subject | Caenorhabditis elegans | en |
dc.subject | Drosophila melanogaster | en |
dc.subject | gene expression profiling | en |
dc.subject | genetic transcription | en |
dc.subject | genetics | en |
dc.subject | Internet | en |
dc.subject | metabolism | en |
dc.subject | molecular genetics | en |
dc.subject | sequence analysis | en |
dc.subject | signal transduction | en |
dc.subject | software | en |
dc.subject | Animals | en |
dc.subject | Binding Sites | en |
dc.subject | Caenorhabditis elegans | en |
dc.subject | Drosophila melanogaster | en |
dc.subject | Gene Expression Profiling | en |
dc.subject | Gene Expression Regulation | en |
dc.subject | Humans | en |
dc.subject | Internet | en |
dc.subject | Mice | en |
dc.subject | MicroRNAs | en |
dc.subject | Molecular Sequence Annotation | en |
dc.subject | Protein Binding | en |
dc.subject | RNA, Messenger | en |
dc.subject | Sequence Analysis, RNA | en |
dc.subject | Signal Transduction | en |
dc.subject | Software | en |
dc.subject | Transcription Factors | en |
dc.subject | Transcription, Genetic | en |
dc.subject | Oxford University Press | en |
dc.title | DIANA-mirExTra v2.0: Uncovering microRNAs and transcription factors with crucial roles in NGS expression data | en |
dc.type | journalArticle | en |