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Computerized cognitive rehabilitation for treatment of cognitive impairment in multiple sclerosis: An explorative study
dc.creator | Vilou I., Bakirtzis C., Artemiadis A., Ioannidis P., Papadimitriou M., Konstantinopoulou E., Aretouli E., Messinis L., Nasios G., Dardiotis E., Kosmidis M.H., Grigoriadis N. | en |
dc.date.accessioned | 2023-01-31T11:36:52Z | |
dc.date.available | 2023-01-31T11:36:52Z | |
dc.date.issued | 2020 | |
dc.identifier | 10.31083/j.jin.2020.02.35 | |
dc.identifier.issn | 02196352 | |
dc.identifier.uri | http://hdl.handle.net/11615/80628 | |
dc.description.abstract | In this explorative study, forty-seven patients with relapsing-remitting multiple sclerosis were randomized to a custom 6-week cognitive rehabilitation intervention (n = 23) using the BrainHQTM web-based platform and to a control group condition (n = 24). Cognitive rehabilitation intervention consisted of two 40-minute sessions per week. All patients were tested with the Brief International Cognitive Assessment for Multiple Sclerosis battery, the Stroop Color-Word Test, and the trail making test, while the Beck Depression Inventory-Fast Screen questionnaire was used as a measure of mood and the cognitive reserve index as a measure of cognitive reserve. We used the reliable change index, to calculate clinically meaningful changes of performance, and to discriminate between responders and non-responders of this intervention. Statistically significant improvement of the group receiving treatment was observed mainly on measures of verbal and nonverbal episodic memory and, to a lesser extent, on reading speed, selective attention/response inhibition, and visual attention. Verbal memory and visual attention improvements remained significant after considering the corrected for multiple comparisons level of significance. According to reliable change index scores, 12/23 (52.2%) of patients in the intervention group presented meaningful improvement in at least one measure (Greek Verbal Learning Test: 26%, Brief Visuospatial Memory Test-Revised: 17.4%, Stroop-Words test: 13%). This explorative study provides evidence that, at least in the short term, cognitive rehabilitation may improve the cognitive performance of multiple sclerosis patients. © 2020 IMR Press Limited. All rights reserved. | en |
dc.language.iso | en | en |
dc.source | Journal of Integrative Neuroscience | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85088511694&doi=10.31083%2fj.jin.2020.02.35&partnerID=40&md5=7d8106c83abaf114555de4d6f25161e1 | |
dc.subject | adult | en |
dc.subject | Article | en |
dc.subject | attention | en |
dc.subject | Beck Depression Inventory | en |
dc.subject | clinical article | en |
dc.subject | cognitive defect | en |
dc.subject | cognitive rehabilitation | en |
dc.subject | cognitive reserve | en |
dc.subject | controlled study | en |
dc.subject | episodic memory | en |
dc.subject | female | en |
dc.subject | human | en |
dc.subject | male | en |
dc.subject | memory | en |
dc.subject | mood | en |
dc.subject | multiple sclerosis | en |
dc.subject | processing speed | en |
dc.subject | questionnaire | en |
dc.subject | reading | en |
dc.subject | selective attention | en |
dc.subject | Stroop test | en |
dc.subject | trail making test | en |
dc.subject | verbal memory | en |
dc.subject | visual attention | en |
dc.subject | cognitive defect | en |
dc.subject | cognitive remediation therapy | en |
dc.subject | complication | en |
dc.subject | computer assisted therapy | en |
dc.subject | middle aged | en |
dc.subject | multiple sclerosis | en |
dc.subject | pathophysiology | en |
dc.subject | physiology | en |
dc.subject | pilot study | en |
dc.subject | randomized controlled trial | en |
dc.subject | Adult | en |
dc.subject | Cognitive Dysfunction | en |
dc.subject | Cognitive Remediation | en |
dc.subject | Cognitive Reserve | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Multiple Sclerosis, Relapsing-Remitting | en |
dc.subject | Outcome Assessment, Health Care | en |
dc.subject | Pilot Projects | en |
dc.subject | Therapy, Computer-Assisted | en |
dc.subject | IMR Press Limited | en |
dc.title | Computerized cognitive rehabilitation for treatment of cognitive impairment in multiple sclerosis: An explorative study | en |
dc.type | journalArticle | en |
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