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The rat closely mimics oxidative stress and inflammation in humans after exercise but not after exercise combined with vitamin C administration
dc.creator | Veskoukis A.S., Goutianos G., Paschalis V., Margaritelis N.V., Tzioura A., Dipla K., Zafeiridis A., Vrabas I.S., Kyparos A., Nikolaidis M.G. | en |
dc.date.accessioned | 2023-01-31T10:32:30Z | |
dc.date.available | 2023-01-31T10:32:30Z | |
dc.date.issued | 2016 | |
dc.identifier | 10.1007/s00421-016-3336-8 | |
dc.identifier.issn | 14396319 | |
dc.identifier.uri | http://hdl.handle.net/11615/80596 | |
dc.description.abstract | Purpose: The purpose of the present study was to directly compare oxidative stress and inflammation responses between rats and humans. Methods: We contrasted rat and human oxidative stress and inflammatory responses to exercise (pro-oxidant stimulus) and/or vitamin C (anti-oxidant stimulus) administration. Vitamin C was administered orally in both species (16 mg kg−1 of body weight). Twelve redox biomarkers and seven inflammatory biomarkers were determined in plasma and erythrocytes pre- and post-exercise or pre- and post-exercise combined with vitamin C administration. Results: Exercise increased oxidative stress and induced an inflammatory state in rats and humans. There were only 1/19 significant species × exercise interactions (catalase), indicating similar responses to exercise between rats and humans in redox and inflammatory biomarkers. Vitamin C decreased oxidative stress and increased antioxidant capacity only in humans and did not affect the redox state of rats. In contrast, vitamin C induced an anti-inflammatory state only in rats and did not affect the inflammatory state of humans. There were 10/19 significant species × vitamin C interactions, indicating that rats poorly mimic human oxidative stress and inflammatory responses to vitamin C administration. Exercise after acute vitamin C administration altered redox state only in humans and did not affect the redox state of rats. On the contrary, inflammation biomarkers changed similarly after exercise combined with vitamin C in both rats and humans. Conclusions: The rat adequately mimics human responses to exercise in basic blood redox/inflammatory profile, yet this is not the case after exercise combined with vitamin C administration. © 2016, Springer-Verlag Berlin Heidelberg. | en |
dc.language.iso | en | en |
dc.source | European Journal of Applied Physiology | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84957605784&doi=10.1007%2fs00421-016-3336-8&partnerID=40&md5=9658c412681c509f96e3055550e1325a | |
dc.subject | ascorbic acid | en |
dc.subject | vitamin | en |
dc.subject | adult | en |
dc.subject | animal | en |
dc.subject | animal experiment | en |
dc.subject | case control study | en |
dc.subject | double blind procedure | en |
dc.subject | drug effects | en |
dc.subject | exercise | en |
dc.subject | human | en |
dc.subject | inflammation | en |
dc.subject | male | en |
dc.subject | oxidative stress | en |
dc.subject | randomization | en |
dc.subject | rat | en |
dc.subject | species difference | en |
dc.subject | Wistar rat | en |
dc.subject | Adult | en |
dc.subject | Animals | en |
dc.subject | Ascorbic Acid | en |
dc.subject | Case-Control Studies | en |
dc.subject | Double-Blind Method | en |
dc.subject | Exercise | en |
dc.subject | Humans | en |
dc.subject | Inflammation | en |
dc.subject | Male | en |
dc.subject | Oxidative Stress | en |
dc.subject | Physical Conditioning, Animal | en |
dc.subject | Random Allocation | en |
dc.subject | Rats | en |
dc.subject | Rats, Wistar | en |
dc.subject | Species Specificity | en |
dc.subject | Vitamins | en |
dc.subject | Springer Verlag | en |
dc.title | The rat closely mimics oxidative stress and inflammation in humans after exercise but not after exercise combined with vitamin C administration | en |
dc.type | journalArticle | en |
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