Tutto DSpace

Mostra i principali dati dell'item

Addressing the post-irradiation hypothalamic-pituitary endocrine abnormalities of brain tumors in pediatric patients

dc.creatorVelentza L., Tolia M., Christakou C., Nikolaou M., Zerdes I.-N., Tsoukalas N., Hajiioannou J., Tsanadis K., Rigas G., Mitsis M., Theodorou K., Pistevou-Gombaki K., Tsekeris P., Kyrgias G.en
dc.date.accessioned2023-01-31T10:31:22Z
dc.date.available2023-01-31T10:31:22Z
dc.date.issued2017
dc.identifier.issn11070625
dc.identifier.urihttp://hdl.handle.net/11615/80558
dc.description.abstractPurpose: Hypothalamic-pituitary axis is susceptible to radiotherapy, causing endocrine disorders to childhood cancer survivors. We conducted a systematic review in order to assess the radiation-induced toxicity that leads to hormone secretion abnormalities and their severity in children with brain tumors. Methods: The data were collected by relevant studies on PubMed and EMBASE. Articles up to December 2016 were included. We selected studies which focused on children patients (<18 yr old) with brain tumors treated with radiotherapy and the consequences for their endocrine system. Results: Growth hormone (GH) deficiency was the most common post-irradiation abnormality among children cancer survivors, followed by gonadotrophin (GT), thyroid stimulating hormone (TSH), corticotropin (ACTH) and prolactin (PRL) disorders. Conclusions: The age of the patient, total radiotherapy dose, number of fractions, fraction size and the duration of treatment seem to determine the severity of these disturbances. © 2017 Zerbinis Publications. All rights reserved.en
dc.language.isoenen
dc.sourceJournal of B.U.ON.en
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85045557849&partnerID=40&md5=833ee3eaaee05171630deaf7b47d5dd9
dc.subjectbrain radiationen
dc.subjectbrain tumoren
dc.subjectcancer radiotherapyen
dc.subjectchildhood cancer survivoren
dc.subjectchildhood diseaseen
dc.subjectclinical assessmenten
dc.subjectcorticotropin deficiencyen
dc.subjectdisease severityen
dc.subjectfollitropin disorderen
dc.subjectgonadotropin deficiencyen
dc.subjectgrowth hormone deficiencyen
dc.subjecthormone deficiencyen
dc.subjecthormone releaseen
dc.subjecthumanen
dc.subjecthypothalamus hypophysis systemen
dc.subjectirradiationen
dc.subjectluteinizing hormone disordeen
dc.subjectprolactin disorderen
dc.subjectradiation injuryen
dc.subjectReviewen
dc.subjectsystematic reviewen
dc.subjectthyrotropin disorderen
dc.subjectadolescenten
dc.subjectbrain tumoren
dc.subjectchilden
dc.subjectcomplicationen
dc.subjectfemaleen
dc.subjecthypophysisen
dc.subjecthypothalamusen
dc.subjectmaleen
dc.subjectpathologyen
dc.subjectpreschool childen
dc.subjectradiation injuryen
dc.subjectradiation responseen
dc.subjectAdolescenten
dc.subjectBrain Neoplasmsen
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectHypothalamusen
dc.subjectMaleen
dc.subjectPituitary Glanden
dc.subjectRadiation Injuriesen
dc.subjectZerbinis Publicationsen
dc.titleAddressing the post-irradiation hypothalamic-pituitary endocrine abnormalities of brain tumors in pediatric patientsen
dc.typeotheren


Files in questo item

FilesDimensioneFormatoMostra

Nessun files in questo item.

Questo item appare nelle seguenti collezioni

Mostra i principali dati dell'item