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The genetic map of diabetic nephropathy: Evidence from a systematic review and meta-analysis of genetic association studies
dc.creator | Tziastoudi M., Stefanidis I., Zintzaras E. | en |
dc.date.accessioned | 2023-01-31T10:21:47Z | |
dc.date.available | 2023-01-31T10:21:47Z | |
dc.date.issued | 2020 | |
dc.identifier | 10.1093/CKJ/SFAA077 | |
dc.identifier.issn | 20488505 | |
dc.identifier.uri | http://hdl.handle.net/11615/80246 | |
dc.description.abstract | Despite the extensive efforts of scientists, the genetic background of diabetic nephropathy (DN) has not yet been clarified. To elucidate the genetic variants that predispose to the development of DN, we conducted a systematic review and meta-analysis of all available genetic association studies (GAS) of DN. We searched in the Human Genome Epidemiology Navigator (HuGE Navigator) and PubMed for available GAS of DN. The threshold for meta-analysis was three studies per genetic variant. The association between genotype distribution and DN was examined using the generalized linear odds ratio (ORG). For variants with available allele frequencies, the examined model was the allele contrast. The pooled OR was estimated using the DerSimonian and Laird random effects model. The publication bias was assessed with Egger's test. We performed pathway analysis of significant genes with DAVID 6.7. Genetic data of 606 variants located in 228 genes were retrieved from 360 GASs and were synthesized with meta-analytic methods. ACACB, angiotensin I-converting enzyme (ACE), ADIPOQ, AGT, AGTR1, AKR1B1, APOC1, APOE, ATP1B2, ATP2A3, CARS, CCR5, CGNL1, Carnosine dipeptidase 1 (CNDP1), CYGB-PRCD, EDN1, Engulfment and cell motility 1 (ELMO1), ENPP1, EPO, FLT4, FTO, GLO1, HMGA2, IGF2/INS/TH cluster, interleukin 1B (IL1B), IL8, IL10, KCNQ1, KNG, LOC101927627, Methylenetetrahydrofolate reductase, nitric oxide synthase 3 (NOS3), SET domain containing seven, histone lysine methyltransferase (SETD7), Sirtuin 1 (SIRT1), SLC2A1, SLC2A2, SLC12A3, SLC19A3, TCF7L2, TGFB1, TIMP1, TTC39C, UNC13B, VEGFA, WTAPP1, WWC1 as well as XYLT1 and three intergenic polymorphisms showed significant association with DN. Pathway analysis revealed the overrepresentation of six signalling pathways.The significant findings provide further evidence for genetic factors implication in DN offering new perspectives in discovery of new therapies. © The Author(s) 2020. Published by Oxford University Press on behalf of ERA-EDTA. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. | en |
dc.language.iso | en | en |
dc.source | Clinical Kidney Journal | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101071282&doi=10.1093%2fCKJ%2fSFAA077&partnerID=40&md5=4be420d2eed87aba3f0c969a2e7f988c | |
dc.subject | 5,10 methylenetetrahydrofolate reductase (FADH2) | en |
dc.subject | acetyl coenzyme A carboxylase | en |
dc.subject | acetyl coenzyme A carboxylase beta | en |
dc.subject | adipocytokine | en |
dc.subject | adiponectin | en |
dc.subject | apolipoprotein E | en |
dc.subject | carnosine dipeptidase 1 | en |
dc.subject | chemokine receptor CCR5 | en |
dc.subject | dipeptidyl carboxypeptidase | en |
dc.subject | endothelial nitric oxide synthase | en |
dc.subject | engulfment and cell motility 1 protein | en |
dc.subject | glucose transporter 1 | en |
dc.subject | glucose transporter 2 | en |
dc.subject | high mobility group A2 protein | en |
dc.subject | histone lysine methyltransferase | en |
dc.subject | interleukin 10 | en |
dc.subject | interleukin 1beta | en |
dc.subject | interleukin 8 | en |
dc.subject | potassium channel KCNQ1 | en |
dc.subject | pyruvic acid | en |
dc.subject | SET domain containing 7 histone lysine methyltransferase | en |
dc.subject | sirtuin 1 | en |
dc.subject | sodium chloride cotransporter | en |
dc.subject | somatomedin B | en |
dc.subject | tissue inhibitor of metalloproteinase 1 | en |
dc.subject | transcription factor 7 like 2 | en |
dc.subject | transforming growth factor beta1 | en |
dc.subject | unclassified drug | en |
dc.subject | vasculotropin A | en |
dc.subject | vasculotropin receptor 3 | en |
dc.subject | ACACB gene | en |
dc.subject | AGT gene | en |
dc.subject | AGTR1 gene | en |
dc.subject | AKR1B1 gene | en |
dc.subject | APOC1 gene | en |
dc.subject | ATP1B2 gene | en |
dc.subject | ATP2A3 gene | en |
dc.subject | CARS gene | en |
dc.subject | CGNL1 gene | en |
dc.subject | CYGB-PRCD gene | en |
dc.subject | diabetic nephropathy | en |
dc.subject | EDN1 gene | en |
dc.subject | endothelium | en |
dc.subject | ENPP1 gene | en |
dc.subject | epigenetics | en |
dc.subject | EPO gene | en |
dc.subject | FTO gene | en |
dc.subject | gene | en |
dc.subject | gene frequency | en |
dc.subject | gene mapping | en |
dc.subject | genetic association | en |
dc.subject | genetic variability | en |
dc.subject | genotype | en |
dc.subject | GLO1 gene | en |
dc.subject | heredity | en |
dc.subject | human | en |
dc.subject | insulin dependent diabetes mellitus | en |
dc.subject | KNG gene | en |
dc.subject | lipid metabolism | en |
dc.subject | LOC101927627 gene | en |
dc.subject | Medline | en |
dc.subject | meta analysis | en |
dc.subject | metabolism | en |
dc.subject | non insulin dependent diabetes mellitus | en |
dc.subject | priority journal | en |
dc.subject | renal cell carcinoma | en |
dc.subject | renin angiotensin aldosterone system | en |
dc.subject | Review | en |
dc.subject | signal transduction | en |
dc.subject | single nucleotide polymorphism | en |
dc.subject | SLC19A3 gene | en |
dc.subject | systematic review | en |
dc.subject | TTC39C gene | en |
dc.subject | UNC13B gene | en |
dc.subject | WTAPP1 gene | en |
dc.subject | WWC1 gene | en |
dc.subject | XYLT1 gene | en |
dc.subject | Oxford University Press | en |
dc.title | The genetic map of diabetic nephropathy: Evidence from a systematic review and meta-analysis of genetic association studies | en |
dc.type | other | en |
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