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Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer

dc.creatorStrakova A., Nicholls T.J., Baez-Ortega A., Ní Leathlobhair M., Sampson A.T., Hughes K., Bolton I.A.G., Gori K., Wang J., Airikkala-Otter I., Allen J.L., Allum K.M., Arnold C.L., Bansse-Issa L., Bhutia T.N., Bisson J.L., Blank K., Briceño C., Castillo Domracheva A., Corrigan A.M., Cran H.R., Crawford J.T., Cutter S.M., Davis E., de Castro K.F., De Nardi A.B., de Vos A.P., Delgadillo Keenan L., Donelan E.M., Espinoza Huerta A.R., Faramade I.A., Fazil M., Fotopoulou E., Fruean S.N., Gallardo-Arrieta F., Glebova O., Gouletsou P.G., Häfelin Manrique R.F., Henriques J.J.G.P., Horta R.S., Ignatenko N., Kane Y., King C., Koenig D., Krupa A., Kruzeniski S.J., Lanza-Perea M., Lazyan M., Lopez Quintana A.M., Losfelt T., Marino G., Martínez Castañeda S., Martínez-López M.F., Masuruli B.M., Meyer M., Migneco E.J., Nakanwagi B., Neal K.B., Neunzig W., Nixon S.J., Ortega-Pacheco A., Pedraza-Ordoñez F., Peleteiro M.C., Polak K., Pye R.J., Ramirez-Ante J.C., Reece J.F., Rojas Gutierrez J., Sadia H., Schmeling S.K., Shamanova O., Sherlock A.G., Steenland-Smit A.E., Svitich A., Tapia Martínez L.J., Thoya Ngoka I., Torres C.G., Tudor E.M., van der Wel M.G., Vițălaru B.A., Vural S.A., Walkinton O., Wehrle-Martinez A.S., Widdowson S.A.E., Zvarich I., Chinnery P.F., Falkenberg M., Gustafsson C.M., Murchison E.P.en
dc.date.accessioned2023-01-31T10:04:15Z
dc.date.available2023-01-31T10:04:15Z
dc.date.issued2020
dc.identifier10.1038/s41467-020-16765-w
dc.identifier.issn20411723
dc.identifier.urihttp://hdl.handle.net/11615/79497
dc.description.abstractAutonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for ‘selfish’ traits, such as replicative advantage. However, few cases of this phenomenon arising within natural populations have been described. Here, we survey the frequency of mtDNA horizontal transfer within the canine transmissible venereal tumour (CTVT), a contagious cancer clone that occasionally acquires mtDNA from its hosts. Remarkably, one canine mtDNA haplotype, A1d1a, has repeatedly and recently colonised CTVT cells, recurrently replacing incumbent CTVT haplotypes. An A1d1a control region polymorphism predicted to influence transcription is fixed in the products of an A1d1a recombination event and occurs somatically on other CTVT mtDNA backgrounds. We present a model whereby ‘selfish’ positive selection acting on a regulatory variant drives repeated fixation of A1d1a within CTVT cells. © 2020, The Author(s).en
dc.language.isoenen
dc.sourceNature Communicationsen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85086571979&doi=10.1038%2fs41467-020-16765-w&partnerID=40&md5=246e6476f5f4f22274e21167de47a317
dc.subjectmitochondrial DNAen
dc.subjectmitochondrial DNAen
dc.subjectcanceren
dc.subjectcell componenten
dc.subjectmitochondrial DNAen
dc.subjectmitochondrionen
dc.subjectpolymorphismen
dc.subjecttumoren
dc.subjectA1d1aen
dc.subjectArticleen
dc.subjectcanine transmissible venereal tumoren
dc.subjectconserved sequenceen
dc.subjectcopy number variationen
dc.subjectgene frequencyen
dc.subjectgenetic variabilityen
dc.subjecthaplotypeen
dc.subjecthorizontal gene transferen
dc.subjectmitochondrial geneen
dc.subjectnonhumanen
dc.subjectphylogenetic treeen
dc.subjectsingle nucleotide polymorphismen
dc.subjectsomatic mutationen
dc.subjectanimalen
dc.subjectanimal venereal tumoren
dc.subjectdogen
dc.subjectdog diseaseen
dc.subjectgenetic polymorphismen
dc.subjectgenetic selectionen
dc.subjectgeneticsen
dc.subjecthaplotypeen
dc.subjecthorizontal gene transferen
dc.subjectphylogenyen
dc.subjectrecurrent diseaseen
dc.subjectAnimalsen
dc.subjectDNA, Mitochondrialen
dc.subjectDog Diseasesen
dc.subjectDogsen
dc.subjectGene Transfer, Horizontalen
dc.subjectHaplotypesen
dc.subjectPhylogenyen
dc.subjectPolymorphism, Geneticen
dc.subjectRecurrenceen
dc.subjectSelection, Geneticen
dc.subjectVenereal Tumors, Veterinaryen
dc.subjectNature Researchen
dc.titleRecurrent horizontal transfer identifies mitochondrial positive selection in a transmissible canceren
dc.typejournalArticleen


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