Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer
dc.creator | Strakova A., Nicholls T.J., Baez-Ortega A., Ní Leathlobhair M., Sampson A.T., Hughes K., Bolton I.A.G., Gori K., Wang J., Airikkala-Otter I., Allen J.L., Allum K.M., Arnold C.L., Bansse-Issa L., Bhutia T.N., Bisson J.L., Blank K., Briceño C., Castillo Domracheva A., Corrigan A.M., Cran H.R., Crawford J.T., Cutter S.M., Davis E., de Castro K.F., De Nardi A.B., de Vos A.P., Delgadillo Keenan L., Donelan E.M., Espinoza Huerta A.R., Faramade I.A., Fazil M., Fotopoulou E., Fruean S.N., Gallardo-Arrieta F., Glebova O., Gouletsou P.G., Häfelin Manrique R.F., Henriques J.J.G.P., Horta R.S., Ignatenko N., Kane Y., King C., Koenig D., Krupa A., Kruzeniski S.J., Lanza-Perea M., Lazyan M., Lopez Quintana A.M., Losfelt T., Marino G., Martínez Castañeda S., Martínez-López M.F., Masuruli B.M., Meyer M., Migneco E.J., Nakanwagi B., Neal K.B., Neunzig W., Nixon S.J., Ortega-Pacheco A., Pedraza-Ordoñez F., Peleteiro M.C., Polak K., Pye R.J., Ramirez-Ante J.C., Reece J.F., Rojas Gutierrez J., Sadia H., Schmeling S.K., Shamanova O., Sherlock A.G., Steenland-Smit A.E., Svitich A., Tapia Martínez L.J., Thoya Ngoka I., Torres C.G., Tudor E.M., van der Wel M.G., Vițălaru B.A., Vural S.A., Walkinton O., Wehrle-Martinez A.S., Widdowson S.A.E., Zvarich I., Chinnery P.F., Falkenberg M., Gustafsson C.M., Murchison E.P. | en |
dc.date.accessioned | 2023-01-31T10:04:15Z | |
dc.date.available | 2023-01-31T10:04:15Z | |
dc.date.issued | 2020 | |
dc.identifier | 10.1038/s41467-020-16765-w | |
dc.identifier.issn | 20411723 | |
dc.identifier.uri | http://hdl.handle.net/11615/79497 | |
dc.description.abstract | Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for ‘selfish’ traits, such as replicative advantage. However, few cases of this phenomenon arising within natural populations have been described. Here, we survey the frequency of mtDNA horizontal transfer within the canine transmissible venereal tumour (CTVT), a contagious cancer clone that occasionally acquires mtDNA from its hosts. Remarkably, one canine mtDNA haplotype, A1d1a, has repeatedly and recently colonised CTVT cells, recurrently replacing incumbent CTVT haplotypes. An A1d1a control region polymorphism predicted to influence transcription is fixed in the products of an A1d1a recombination event and occurs somatically on other CTVT mtDNA backgrounds. We present a model whereby ‘selfish’ positive selection acting on a regulatory variant drives repeated fixation of A1d1a within CTVT cells. © 2020, The Author(s). | en |
dc.language.iso | en | en |
dc.source | Nature Communications | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85086571979&doi=10.1038%2fs41467-020-16765-w&partnerID=40&md5=246e6476f5f4f22274e21167de47a317 | |
dc.subject | mitochondrial DNA | en |
dc.subject | mitochondrial DNA | en |
dc.subject | cancer | en |
dc.subject | cell component | en |
dc.subject | mitochondrial DNA | en |
dc.subject | mitochondrion | en |
dc.subject | polymorphism | en |
dc.subject | tumor | en |
dc.subject | A1d1a | en |
dc.subject | Article | en |
dc.subject | canine transmissible venereal tumor | en |
dc.subject | conserved sequence | en |
dc.subject | copy number variation | en |
dc.subject | gene frequency | en |
dc.subject | genetic variability | en |
dc.subject | haplotype | en |
dc.subject | horizontal gene transfer | en |
dc.subject | mitochondrial gene | en |
dc.subject | nonhuman | en |
dc.subject | phylogenetic tree | en |
dc.subject | single nucleotide polymorphism | en |
dc.subject | somatic mutation | en |
dc.subject | animal | en |
dc.subject | animal venereal tumor | en |
dc.subject | dog | en |
dc.subject | dog disease | en |
dc.subject | genetic polymorphism | en |
dc.subject | genetic selection | en |
dc.subject | genetics | en |
dc.subject | haplotype | en |
dc.subject | horizontal gene transfer | en |
dc.subject | phylogeny | en |
dc.subject | recurrent disease | en |
dc.subject | Animals | en |
dc.subject | DNA, Mitochondrial | en |
dc.subject | Dog Diseases | en |
dc.subject | Dogs | en |
dc.subject | Gene Transfer, Horizontal | en |
dc.subject | Haplotypes | en |
dc.subject | Phylogeny | en |
dc.subject | Polymorphism, Genetic | en |
dc.subject | Recurrence | en |
dc.subject | Selection, Genetic | en |
dc.subject | Venereal Tumors, Veterinary | en |
dc.subject | Nature Research | en |
dc.title | Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer | en |
dc.type | journalArticle | en |
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