Genetic spatiotemporal anatomy of plasmodium vivax malaria episodes in Greece, 2009–2013
dc.creator | Spanakos G., Snounou G., Pervanidou D., Alifrangis M., Rosanas-Urgell A., Baka A., Tseroni M., Vakali A., Vassalou E., Patsoula E., Zeller H., Van Bortel W., Hadjichristodoulou C., MALWEST Project | en |
dc.date.accessioned | 2023-01-31T09:59:42Z | |
dc.date.available | 2023-01-31T09:59:42Z | |
dc.date.issued | 2018 | |
dc.identifier | 10.3201/eid2403.170605 | |
dc.identifier.issn | 10806040 | |
dc.identifier.uri | http://hdl.handle.net/11615/79239 | |
dc.description.abstract | An influx of immigrants is contributing to the reemergence of Plasmodium vivax malaria in Greece; 1 persistent focus of transmission is in Laconia, Pelopónnese. We genotyped archived blood samples from a substantial proportion of malaria cases recorded in GreecePvMSP-3αin 2009–2013 using 8 microsatellite markers and a gene fragment and plotted their spatiotemporal distribution. High parasite genetic diversity with low multiplicity of infection was observed. A subset of genetically identical/related parasites was restricted to 3 areas in migrants and Greek residents, with some persisting over 2 consecutive transmission periods. We identified 2 hitherto unsuspected additional foci of local transmission: Kardhítsa and Attica. Furthermore, this analysis indicates that several cases in migrants initially classified as imported malaria were actually locally acquired. This study shows the potential for P. vivax to reestablish transmission and counsels public health authorities about the need for vigilance to achieve or maintain sustainable malaria elimination. © 2018, Centers for Disease Control and Prevention (CDC). All rights reserved. | en |
dc.language.iso | en | en |
dc.source | Emerging Infectious Diseases | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85042273844&doi=10.3201%2feid2403.170605&partnerID=40&md5=01f7d7a58164e38aa6559f8437536ba4 | |
dc.subject | anatomy | en |
dc.subject | Article | en |
dc.subject | disease clearance | en |
dc.subject | disease transmission | en |
dc.subject | gene amplification | en |
dc.subject | genetic spatiotemporal anatomy | en |
dc.subject | genotype | en |
dc.subject | Greece | en |
dc.subject | haplotype | en |
dc.subject | human | en |
dc.subject | immigrant | en |
dc.subject | major clinical study | en |
dc.subject | microscopy | en |
dc.subject | Plasmodium vivax malaria | en |
dc.subject | polymerase chain reaction | en |
dc.subject | allele | en |
dc.subject | genetic variation | en |
dc.subject | genetics | en |
dc.subject | genome | en |
dc.subject | geography | en |
dc.subject | history | en |
dc.subject | parasitology | en |
dc.subject | Plasmodium vivax | en |
dc.subject | Plasmodium vivax malaria | en |
dc.subject | spatiotemporal analysis | en |
dc.subject | transmission | en |
dc.subject | Alleles | en |
dc.subject | Genetic Variation | en |
dc.subject | Genome, Protozoan | en |
dc.subject | Genotype | en |
dc.subject | Geography | en |
dc.subject | Greece | en |
dc.subject | History, 21st Century | en |
dc.subject | Humans | en |
dc.subject | Malaria, Vivax | en |
dc.subject | Plasmodium vivax | en |
dc.subject | Spatio-Temporal Analysis | en |
dc.subject | Centers for Disease Control and Prevention (CDC) | en |
dc.title | Genetic spatiotemporal anatomy of plasmodium vivax malaria episodes in Greece, 2009–2013 | en |
dc.type | journalArticle | en |
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