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Deciphering the role of DNA methylation in multiple sclerosis: emerging issues

dc.creatorSokratous M., Dardiotis E., Tsouris Z., Bellou E., Michalopoulou A., Siokas V., Arseniou S., Stamati T., Tsivgoulis G., Bogdanos D., Hadjigeorgiou G.M.en
dc.date.accessioned2023-01-31T09:58:42Z
dc.date.available2023-01-31T09:58:42Z
dc.date.issued2016
dc.identifier10.1007/s13317-016-0084-z
dc.identifier.issn20380305
dc.identifier.urihttp://hdl.handle.net/11615/79171
dc.description.abstractMultiple sclerosis (MS) is an autoimmune inflammatory and neurodegenerative disease of the central nervous system that involves several not yet fully elucidated pathophysiologic mechanisms. There is increasing evidence that epigenetic modifications at level of DNA bases, histones, and micro-RNAs may confer risk for MS. DNA methylation seems to have a prominent role in the epigenetics of MS, as aberrant methylation in the promoter regions across genome may underlie several processes involved in the initiation and development of MS. In the present review, we discuss current understanding regarding the role of DNA methylation in MS, possible therapeutic implications and future emerging issues. © 2016, The Author(s).en
dc.language.isoenen
dc.sourceAutoimmunity Highlightsen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84986197820&doi=10.1007%2fs13317-016-0084-z&partnerID=40&md5=417f8bfb73e9f5732a0fac6c2cf83a38
dc.subjectDNA methyltransferaseen
dc.subjectDNA methyltransferase 1en
dc.subjectDNA methyltransferase 3Aen
dc.subjectDNA methyltransferase 3Ben
dc.subjectHLA DRB1 antigenen
dc.subjectHLA DRB5 antigenen
dc.subjectArticleen
dc.subjectbinocular convergenceen
dc.subjectDNA methylationen
dc.subjectDNA replicationen
dc.subjectenvironmental factoren
dc.subjectepigeneticsen
dc.subjectgene expressionen
dc.subjectgenetic susceptibilityen
dc.subjecthumanen
dc.subjectmultiple sclerosisen
dc.subjectnonhumanen
dc.subjectpriority journalen
dc.subjectreceptor down regulationen
dc.subjectrheumatoid arthritisen
dc.subjectsystemic lupus erythematosusen
dc.subjectSpringer-Verlag Italia s.r.l.en
dc.titleDeciphering the role of DNA methylation in multiple sclerosis: emerging issuesen
dc.typejournalArticleen


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