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Subjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia

dc.creatorSlot R.E.R., Sikkes S.A.M., Berkhof J., Brodaty H., Buckley R., Cavedo E., Dardiotis E., Guillo-Benarous F., Hampel H., Kochan N.A., Lista S., Luck T., Maruff P., Molinuevo J.L., Kornhuber J., Reisberg B., Riedel-Heller S.G., Risacher S.L., Roehr S., Sachdev P.S., Scarmeas N., Scheltens P., Shulman M.B., Saykin A.J., Verfaillie S.C.J., Visser P.J., Vos S.J.B., Wagner M., Wolfsgruber S., Jessen F., Boada M., de Deyn P.P., Jones R., Frisoni G., Spiru L., Nobili F., Freund-Levi Y., Soininen H., Verhey F., Wallin Å.K., Touchon J., Rikkert M.O., Rigaud A.-S., Bullock R., Tsolaki M., Vellas B., Wilcock G., Froelich L., Bakardjian H., Benali H., Bertin H., Bonheur J., Boukadida L., Boukerrou N., Chiesa P., Colliot O., Dubois B., Dubois M., Epelbaum S., Gagliardi G., Genthon R., Habert M.-O., Houot M., Kas A., Lamari F., Levy M., Metzinger C., Mochel F., Nyasse F., Poisson C., Potier M.-C., Revillon M., Santos A., Andrade K.S., Sole M., Surtee M., Thiebaud de Schotten M., Vergallo A., Younsi N., van der Flier W.M., Alzheimer's Disease Neuroimaging Initiative, DESCRIPA working group, INSIGHT-preAD study group, SCD-I working groupen
dc.date.accessioned2023-01-31T09:58:06Z
dc.date.available2023-01-31T09:58:06Z
dc.date.issued2019
dc.identifier10.1016/j.jalz.2018.10.003
dc.identifier.issn15525260
dc.identifier.urihttp://hdl.handle.net/11615/79127
dc.description.abstractIntroduction: In this multicenter study on subjective cognitive decline (SCD) in community-based and memory clinic settings, we assessed the (1) incidence of Alzheimer's disease (AD) and non-AD dementia and (2) determinants of progression to dementia. Methods: Eleven cohorts provided 2978 participants with SCD and 1391 controls. We estimated dementia incidence and identified risk factors using Cox proportional hazards models. Results: In SCD, incidence of dementia was 17.7 (95% Poisson confidence interval 15.2-20.3)/1000 person-years (AD: 11.5 [9.6-13.7], non-AD: 6.1 [4.7-7.7]), compared with 14.2 (11.3-17.6) in controls (AD: 10.1 [7.7-13.0], non-AD: 4.1 [2.6-6.0]). The risk of dementia was strongly increased in SCD in a memory clinic setting but less so in a community-based setting. In addition, higher age (hazard ratio 1.1 [95% confidence interval 1.1-1.1]), lower Mini–Mental State Examination (0.7 [0.66-0.8]), and apolipoprotein E ε4 (1.8 [1.3-2.5]) increased the risk of dementia. Discussion: SCD can precede both AD and non-AD dementia. Despite their younger age, individuals with SCD in a memory clinic setting have a higher risk of dementia than those in community-based cohorts. © 2018 The Authorsen
dc.language.isoenen
dc.sourceAlzheimer's and Dementiaen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85056582914&doi=10.1016%2fj.jalz.2018.10.003&partnerID=40&md5=199561f0a16ec4a4c3157f32321ec29b
dc.subjectapolipoprotein E4en
dc.subjectadulten
dc.subjectageden
dc.subjectAlzheimer diseaseen
dc.subjectArticleen
dc.subjectcognition assessmenten
dc.subjectcognitive defecten
dc.subjectcohort analysisen
dc.subjectcontrolled studyen
dc.subjectdementiaen
dc.subjectdisease exacerbationen
dc.subjectfemaleen
dc.subjectfrontotemporal dementiaen
dc.subjecthumanen
dc.subjectincidenceen
dc.subjectmajor clinical studyen
dc.subjectmaleen
dc.subjectmemoryen
dc.subjectMini Mental State Examinationen
dc.subjectpriority journalen
dc.subjectrisk assessmenten
dc.subjectrisk factoren
dc.subjectsubjective cognitive declineen
dc.subjectvery elderlyen
dc.subjectclinical trialen
dc.subjectcognitive defecten
dc.subjectdementiaen
dc.subjectmiddle ageden
dc.subjectmulticenter studyen
dc.subjectpsychologyen
dc.subjectself concepten
dc.subjectself evaluationen
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectCognitive Dysfunctionen
dc.subjectCohort Studiesen
dc.subjectDementiaen
dc.subjectDiagnostic Self Evaluationen
dc.subjectDisease Progressionen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectIncidenceen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectRisk Factorsen
dc.subjectSelf Concepten
dc.subjectElsevier Inc.en
dc.titleSubjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementiaen
dc.typejournalArticleen


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