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Curcumin mediates attenuation of pro-inflammatory interferon γ and interleukin 17 cytokine responses in psoriatic disease, strengthening its role as a dietary immunosuppressant
dc.creator | Skyvalidas D.Ν., Mavropoulos A., Tsiogkas S., Dardiotis E., Liaskos C., Mamuris Z., Roussaki-Schulze A., Sakkas L.I., Zafiriou E., Bogdanos D.P. | en |
dc.date.accessioned | 2023-01-31T09:58:03Z | |
dc.date.available | 2023-01-31T09:58:03Z | |
dc.date.issued | 2020 | |
dc.identifier | 10.1016/j.nutres.2020.01.005 | |
dc.identifier.issn | 02715317 | |
dc.identifier.uri | http://hdl.handle.net/11615/79123 | |
dc.description.abstract | Curcumin exhibits anti-inflammatory properties and has been used for centuries in traditional medicine and as dietary supplement. Data from clinical trials has strengthened the notion that curcumin may exert an anti-inflammatory and immunosuppressive role in patients with psoriatic disease, but its mode of action has remained elusive. We hypothesized that curcumin could inhibit interferon (IFN)-γ and interleukin (IL)-17 production in peripheral blood mononuclear cells from patients with psoriasis and psoriatic arthritis (PsA). To this end, we assessed the in vitro effect of curcumin on IFN-γ production by cluster differentiation (CD)4(+), CD8(+) T cells, natural killer (NK) and NKT cells and on IL-17 production by CD4(+) T cells from 34 patients with psoriatic disease (22 with psoriasis and 12 with PsA); 15 normal subjects were included as healthy controls. We also assessed the effect of curcumin on signal transducer and activator of transcription (STAT)3 activation. Curcumin significantly decreased, in a dose dependent manner, IFNγ-production by CD4(+) and CD8(+) T cells, and NK and NKT cells in patients with psoriatic disease and healthy controls. It also decreased IL-17 production by CD4(+) T cells (Th17). At the molecular level, curcumin increased STAT3 serine 727 phosphorylation intensity and p-STAT3(+) CD4(+) T cells in patients with PsA and psoriasis. In conclusion, curcumin in vitro inhibits pro-inflammatory IFN-γ and IL-17 production in psoriatic disease, and this may strengthen its role as a dietary immunosuppressant in patients with this disease. © 2020 Elsevier Inc. | en |
dc.language.iso | en | en |
dc.source | Nutrition Research | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080043084&doi=10.1016%2fj.nutres.2020.01.005&partnerID=40&md5=703f0f8b375be539e2039f56f5a907d0 | |
dc.subject | curcumin | en |
dc.subject | gamma interferon | en |
dc.subject | interleukin 17 | en |
dc.subject | serine | en |
dc.subject | STAT3 protein | en |
dc.subject | antiinflammatory agent | en |
dc.subject | curcumin | en |
dc.subject | gamma interferon | en |
dc.subject | immunosuppressive agent | en |
dc.subject | interleukin 17 | en |
dc.subject | STAT3 protein | en |
dc.subject | STAT3 protein, human | en |
dc.subject | adult | en |
dc.subject | antiinflammatory activity | en |
dc.subject | Article | en |
dc.subject | CD4+ T lymphocyte | en |
dc.subject | CD8+ T lymphocyte | en |
dc.subject | clinical article | en |
dc.subject | concentration response | en |
dc.subject | controlled study | en |
dc.subject | cytokine production | en |
dc.subject | dietary supplement | en |
dc.subject | drug effect | en |
dc.subject | female | en |
dc.subject | human | en |
dc.subject | human cell | en |
dc.subject | in vitro study | en |
dc.subject | lymphocyte differentiation | en |
dc.subject | male | en |
dc.subject | natural killer cell | en |
dc.subject | peripheral blood mononuclear cell | en |
dc.subject | priority journal | en |
dc.subject | protein phosphorylation | en |
dc.subject | protein synthesis inhibition | en |
dc.subject | psoriasis | en |
dc.subject | psoriatic arthritis | en |
dc.subject | Th17 cell | en |
dc.subject | transcription initiation | en |
dc.subject | aged | en |
dc.subject | biosynthesis | en |
dc.subject | diet | en |
dc.subject | immunology | en |
dc.subject | inflammation | en |
dc.subject | metabolism | en |
dc.subject | middle aged | en |
dc.subject | psoriasis | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Anti-Inflammatory Agents | en |
dc.subject | CD4-Positive T-Lymphocytes | en |
dc.subject | CD8-Positive T-Lymphocytes | en |
dc.subject | Curcumin | en |
dc.subject | Diet | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Immunosuppressive Agents | en |
dc.subject | Inflammation | en |
dc.subject | Interferon-gamma | en |
dc.subject | Interleukin-17 | en |
dc.subject | Killer Cells, Natural | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Psoriasis | en |
dc.subject | STAT3 Transcription Factor | en |
dc.subject | Elsevier Inc. | en |
dc.title | Curcumin mediates attenuation of pro-inflammatory interferon γ and interleukin 17 cytokine responses in psoriatic disease, strengthening its role as a dietary immunosuppressant | en |
dc.type | journalArticle | en |
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