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SLC2A1 Tag SNPs in Greek Patients with Diabetic Retinopathy and Nephropathy
dc.creator | Siokas V., Fotiadou A., Dardiotis E., Kotoula M.G., Tachmitzi S.V., Chatzoulis D.Z., Zintzaras E., Stefanidis I., Tsironi E.E. | en |
dc.date.accessioned | 2023-01-31T09:56:52Z | |
dc.date.available | 2023-01-31T09:56:52Z | |
dc.date.issued | 2019 | |
dc.identifier | 10.1159/000480241 | |
dc.identifier.issn | 00303747 | |
dc.identifier.uri | http://hdl.handle.net/11615/79034 | |
dc.description.abstract | Backround: Genetic variants are implicated in the development of diabetic retinopathy (DR) and nephropathy (DN). The role of solute carrier family 2-facilitated glucose transporter member 1 (SLC2A1), also known as glucose transporter (GLUT1), on DR and DN remain controversial. Objective: Examination of the influence of tag SLC2A1 single-nucleotide polymorphisms (SNPs) on the development of DR and DN during the course of type 2 diabetes mellitus (T2DM). Methods: A total of 169 patients with DR or DN, 107 uncomplicated T2DM patients, and 315 controls were recruited and genotyped for 14 SLC2A1 tag SNPs. SNPs and haplotypes were tested for associations with microvascular diabetes' complications. Results: rs3768029 TT genotype was associated with a lower risk of DR + DN, compared to the CC wild-type (p = 0.0024). Moreover, CT and TT rs841847 genotypes were associated with a higher risk of DR + DN compared to the CC genotype (p = 0.0028). A common haplotype (GGCCCGCATCAAT) was associated with an increased risk of DR, DN, DR ± DN, and DR + DN phenotypes. Mutational loads of rs3768029, rs3729548, rs841853, and rs841847 were found to influence the development of microvascular complications during the T2DM course. Conclusions: This study provides evidence that SLC2A1 gene variants might be implicated in the development of T2DM microvascular complications. © 2017 S. Karger AG, Basel. All rights reserved. | en |
dc.language.iso | en | en |
dc.source | Ophthalmic Research | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85037369680&doi=10.1159%2f000480241&partnerID=40&md5=cdb492d5f9157f42433c71acf0b7e0d5 | |
dc.subject | glucose transporter 1 | en |
dc.subject | glucose transporter 1 | en |
dc.subject | SLC2A1 protein, human | en |
dc.subject | adult | en |
dc.subject | Article | en |
dc.subject | cohort analysis | en |
dc.subject | controlled study | en |
dc.subject | diabetic complication | en |
dc.subject | diabetic nephropathy | en |
dc.subject | diabetic retinopathy | en |
dc.subject | disease course | en |
dc.subject | female | en |
dc.subject | gene | en |
dc.subject | genetic linkage | en |
dc.subject | genetic risk | en |
dc.subject | genetic variability | en |
dc.subject | genotyping technique | en |
dc.subject | haplotype | en |
dc.subject | human | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | non insulin dependent diabetes mellitus | en |
dc.subject | pathogenesis | en |
dc.subject | priority journal | en |
dc.subject | single nucleotide polymorphism | en |
dc.subject | SLC2A1 gene | en |
dc.subject | aged | en |
dc.subject | case control study | en |
dc.subject | complication | en |
dc.subject | diabetic retinopathy | en |
dc.subject | genetic predisposition | en |
dc.subject | genetic variation | en |
dc.subject | genetics | en |
dc.subject | genotype | en |
dc.subject | Greece | en |
dc.subject | middle aged | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Case-Control Studies | en |
dc.subject | Diabetes Mellitus, Type 2 | en |
dc.subject | Diabetic Retinopathy | en |
dc.subject | Female | en |
dc.subject | Genetic Predisposition to Disease | en |
dc.subject | Genetic Variation | en |
dc.subject | Genotype | en |
dc.subject | Glucose Transporter Type 1 | en |
dc.subject | Greece | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Polymorphism, Single Nucleotide | en |
dc.subject | S. Karger AG | en |
dc.title | SLC2A1 Tag SNPs in Greek Patients with Diabetic Retinopathy and Nephropathy | en |
dc.type | journalArticle | en |
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