dc.creator | Siokas V., Dardiotis E., Sokolakis T., Kotoula M., Tachmitzi S.V., Chatzoulis D.Z., Almpanidou P., Stefanidis I., Hadjigeorgiou G.M., Tsironi E.E. | en |
dc.date.accessioned | 2023-01-31T09:56:49Z | |
dc.date.available | 2023-01-31T09:56:49Z | |
dc.date.issued | 2017 | |
dc.identifier | 10.1080/02713683.2016.1276197 | |
dc.identifier.issn | 02713683 | |
dc.identifier.uri | http://hdl.handle.net/11615/79031 | |
dc.description.abstract | Background: There is accumulating evidence for genetic susceptibility to the development of diabetic retinopathy (DR). The role of plasminogen activator inhibitor-1 (PAI-1) in DR risk remains controversial. Objective: The present study was designed to investigate possible influence of PAI-1 gene region polymorphisms on the risk of DR and on the risk of developing DR early vs late in the course of type 2 diabetes mellitus (T2DM). Methods: A total of 138 patients with DR, 107 patients with T2DM without DR, and 315 healthy controls were recruited. To cover the majority of the genetic variability across the extended region of PAI-1 gene, five tag single-nucleotide polymorphisms (SNPs) from the HapMap using a pairwise approach and an r2 ≥ 0.8 and a minor allele frequency (MAF) of >0.05 were identified. Using logistic regression analyses, tag SNPs and haplotypes were tested for associations with DR risk and risk of DR development early or late in the course of T2DM. The generalized odds ratio (ORG) was calculated to estimate the mutational load effect on DR development among all participants. Corrections for multiple comparisons were carried out (p-value < 0.01). Results: A significant effect of rs2070682 on the risk of early DR onset was found in the codominant model of inheritance [odds ratio, OR (95% confidence interval, CI): 5.04 (1.47–17.28), p = 0.018]. However, this association marginally did not survive multiple testing corrections. No other significant association between PAI-1 tag-SNPs and haplotypes was revealed. Furthermore, no significant mutational load effect of PAI-1 tag SNPs on the risk of DR development in T2DM course was found. Conclusions: In conclusion, the present study does not provide any strong evidence that PAI-1 gene variants are implicated in the risk of DR or the development of DR during T2DM course. © 2017 Taylor & Francis. | en |
dc.language.iso | en | en |
dc.source | Current Eye Research | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85014449029&doi=10.1080%2f02713683.2016.1276197&partnerID=40&md5=656b708c7c345ba50a87cdf7dd002fa8 | |
dc.subject | plasminogen activator inhibitor 1 | en |
dc.subject | DNA | en |
dc.subject | plasminogen activator inhibitor 1 | en |
dc.subject | Article | en |
dc.subject | codominance | en |
dc.subject | controlled study | en |
dc.subject | diabetic retinopathy | en |
dc.subject | female | en |
dc.subject | gene frequency | en |
dc.subject | genetic association | en |
dc.subject | genetic risk | en |
dc.subject | haplotype | en |
dc.subject | human | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | mutational load | en |
dc.subject | non insulin dependent diabetes mellitus | en |
dc.subject | pathogenesis | en |
dc.subject | priority journal | en |
dc.subject | single nucleotide polymorphism | en |
dc.subject | diabetic retinopathy | en |
dc.subject | exon | en |
dc.subject | genetics | en |
dc.subject | genotype | en |
dc.subject | metabolism | en |
dc.subject | non insulin dependent diabetes mellitus | en |
dc.subject | Diabetes Mellitus, Type 2 | en |
dc.subject | Diabetic Retinopathy | en |
dc.subject | DNA | en |
dc.subject | Exons | en |
dc.subject | Female | en |
dc.subject | Genotype | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Plasminogen Activator Inhibitor 1 | en |
dc.subject | Polymorphism, Single Nucleotide | en |
dc.subject | Taylor and Francis Ltd | en |
dc.title | Plasminogen Activator Inhibitor Type-1 Tag Single-Nucleotide Polymorphisms in Patients with Diabetes Mellitus Type 2 and Diabetic Retinopathy | en |
dc.type | journalArticle | en |