dc.creator | Sifakis S., Androutsopoulos V.P., Pontikaki A., Velegrakis A., Papaioannou G.I., Koukoura O., Spandidos D.A., Papantoniou N. | en |
dc.date.accessioned | 2023-01-31T09:56:01Z | |
dc.date.available | 2023-01-31T09:56:01Z | |
dc.date.issued | 2018 | |
dc.identifier | 10.3892/mmr.2018.8721 | |
dc.identifier.issn | 17912997 | |
dc.identifier.uri | http://hdl.handle.net/11615/78971 | |
dc.description.abstract | Fetal growth restriction (FGR) is a gynecological disorder of varying etiology. In the present study, an expression analysis of pregnancy-associated plasma protein A (PAPPA), pregnancy-associated plasma protein A2 (PAPPA2) and placenta-specific-1 (PLAC-1) was conducted in pregnancies with FGR and control pregnancies. Placental tissues were collected from pregnancies with FGR (n=16) and control pregnancies (n=16) and the expression of the genes of interest was examined by qPCR. The mean expression levels of PAPPA and PAPPA2 were significantly lower (P<0.001) in placental tissues from FGR pregnancies compared with tissues from healthy subjects, whereas the opposite pattern was observed for PLAC-1 (P<0.001). PAPPA and PLAC-1 expression in FGR and control subjects correlated with birth weight (P<0.001). The findings suggest a possible pathophysiological link between the development of FGR and the expression of PAPPA, PAPPA2 and PLAC-1. © 2018 Spandidos Publications. All rights reserved. | en |
dc.language.iso | en | en |
dc.source | Molecular Medicine Reports | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85044728563&doi=10.3892%2fmmr.2018.8721&partnerID=40&md5=8e34e52cf88de446d67dc56485e46f35 | |
dc.subject | placenta protein | en |
dc.subject | placenta specific 1 protein | en |
dc.subject | pregnancy associated plasma protein A | en |
dc.subject | pregnancy associated plasma protein A2 | en |
dc.subject | unclassified drug | en |
dc.subject | PAPPA2 protein, human | en |
dc.subject | PLAC1 protein, human | en |
dc.subject | placenta protein | en |
dc.subject | pregnancy associated plasma protein A | en |
dc.subject | adult | en |
dc.subject | Article | en |
dc.subject | birth weight | en |
dc.subject | clinical article | en |
dc.subject | controlled study | en |
dc.subject | female | en |
dc.subject | gene expression | en |
dc.subject | human | en |
dc.subject | human tissue | en |
dc.subject | intrauterine growth retardation | en |
dc.subject | placenta tissue | en |
dc.subject | pregnancy | en |
dc.subject | biosynthesis | en |
dc.subject | gene expression regulation | en |
dc.subject | intrauterine growth retardation | en |
dc.subject | metabolism | en |
dc.subject | pathology | en |
dc.subject | placenta | en |
dc.subject | pregnancy | en |
dc.subject | Adult | en |
dc.subject | Female | en |
dc.subject | Fetal Growth Retardation | en |
dc.subject | Gene Expression Regulation | en |
dc.subject | Humans | en |
dc.subject | Placenta | en |
dc.subject | Pregnancy | en |
dc.subject | Pregnancy Proteins | en |
dc.subject | Pregnancy-Associated Plasma Protein-A | en |
dc.subject | Spandidos Publications | en |
dc.title | Placental expression of PAPPA, PAPPA-2 and PLAC-1 in pregnacies is associated with FGR | en |
dc.type | journalArticle | en |