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Two Dimensional Drug Diffusion between Nanoparticles and Fractal Tumors
dc.creator | Samioti S.E., Karamanos K., Tsiantis A., Papathanasiou A., Sarris I. | en |
dc.date.accessioned | 2023-01-31T09:53:42Z | |
dc.date.available | 2023-01-31T09:53:42Z | |
dc.date.issued | 2017 | |
dc.identifier | 10.1088/1742-6596/931/1/012034 | |
dc.identifier.issn | 17426588 | |
dc.identifier.uri | http://hdl.handle.net/11615/78764 | |
dc.description.abstract | Drug delivery methods based on nanoparticles are some of the most promising medical applications in nanotechnology to treat cancer. It is observed that drug released by nanoparticles to the cancer tumors may be driven by diffusion. A fractal tumor boundary of triangular Von Koch shape is considered here and the diffusion mechanism is studied for different drug concentrations and increased fractality. A high order Finite Elements method based on the Fenics library is incorporated in fine meshes to fully resolve these irregular boundaries. Drug concentration, its transfer rates and entropy production are calculated in an up to forth order fractal iteration boundaries. We observed that diffusion rate diminishes for successive prefractal generations. Also, the entropy production around the system changes greatly as the order of the fractal curve increases. Results indicate with precision where the active sites are, in which most of the diffusion takes place and thus drug arrives to the tumor. © Published under licence by IOP Publishing Ltd. | en |
dc.language.iso | en | en |
dc.source | Journal of Physics: Conference Series | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85039436203&doi=10.1088%2f1742-6596%2f931%2f1%2f012034&partnerID=40&md5=6b345d8ba0edccb06dd3ed84caa177ad | |
dc.subject | Diffusion | en |
dc.subject | Diseases | en |
dc.subject | Entropy | en |
dc.subject | Finite element method | en |
dc.subject | Iterative methods | en |
dc.subject | Medical applications | en |
dc.subject | Medical nanotechnology | en |
dc.subject | Nanoparticles | en |
dc.subject | Tumors | en |
dc.subject | Delivery methods | en |
dc.subject | Diffusion mechanisms | en |
dc.subject | Drug concentration | en |
dc.subject | Entropy production | en |
dc.subject | Fractal curves | en |
dc.subject | High-order finite elements | en |
dc.subject | Irregular boundary | en |
dc.subject | Prefractal generation | en |
dc.subject | Fractals | en |
dc.subject | Institute of Physics Publishing | en |
dc.title | Two Dimensional Drug Diffusion between Nanoparticles and Fractal Tumors | en |
dc.type | conferenceItem | en |
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