dc.creator | Roumpeas E., Kostoulas P., Polizopoulou Z., Koutinas C.K., Mylonakis M.E. | en |
dc.date.accessioned | 2023-01-31T09:52:07Z | |
dc.date.available | 2023-01-31T09:52:07Z | |
dc.date.issued | 2016 | |
dc.identifier | 10.1007/s00580-016-2297-y | |
dc.identifier.issn | 16185641 | |
dc.identifier.uri | http://hdl.handle.net/11615/78594 | |
dc.description.abstract | Limited information is currently available regarding the range of D-dimer concentrations in dogs with kidney disease (KD). The objective of the present cross-sectional study was to investigate the concentration of D-dimers in dogs with KD irrelevant of the underlying cause or the time course of the KD and the potential association of D-dimers elevation with serum creatinine concentration, concurrent protein-losing nephropathy (PLN) or the age of the animals. D-dimers were measured by a semi-quantitative plasma latex agglutination assay in 31 healthy dogs (group A) and in 30 dogs with KD (group B), without evidence of concurrent extra-renal disease that may precipitate hypercoagulation. Significantly higher median D-dimer concentrations (p = 0.0133) and a higher prevalence of increased D-dimers (≥250 μg/L) (p = 0.011) were documented in dogs with KD as compared to healthy dogs, and the increased D-dimers were not associated with the serum creatinine concentration, the coexistent PLN or the age of the dogs. In conclusion, the detection of increased D-dimers in the context of impaired kidney function should be cautiously interpreted in the dog and should not be invariably assumed to imply the presence of a state of hypercoagulability. © 2016, Springer-Verlag London. | en |
dc.language.iso | en | en |
dc.source | Comparative Clinical Pathology | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84978173466&doi=10.1007%2fs00580-016-2297-y&partnerID=40&md5=e6075eab590c184f220957b07153106b | |
dc.subject | Springer-Verlag London Ltd | en |
dc.title | D-dimer concentrations in dogs with kidney disease with or without protein-losing nephropathy | en |
dc.type | journalArticle | en |