dc.creator | Rouka E., Kotsiou O.S., Perlepe G., Pagonis A., Pantazopoulos I., Gourgoulianis K.I. | en |
dc.date.accessioned | 2023-01-31T09:51:54Z | |
dc.date.available | 2023-01-31T09:51:54Z | |
dc.date.issued | 2021 | |
dc.identifier | 10.1155/2021/6590528 | |
dc.identifier.issn | 11982241 | |
dc.identifier.uri | http://hdl.handle.net/11615/78567 | |
dc.description.abstract | Background. The direct effect of SARS-CoV-2 on the lungs results in increased hospitalization rates of patients with pneumonia. Severe COVID-19 patients often develop ARDS which is associated with poor prognosis. Assessing risk factors for COVID-19 severity is indispensable for implementing and evaluating therapeutic interventions. We investigated the temporal associations between the SARS-CoV-2 antigen (Ag), total Immunoglobulin (Ig) levels, and several laboratory parameters in hospitalized patients with varying degrees of COVID-19 severity. Methods. The SARS-CoV-2 nucleocapsid protein (NP) and total Ig Spike (S) protein-specific antibodies were determined for each patient with lateral flow assays through repeated sampling every two days. Hematological and biochemical parameters were evaluated at the same time points. Results. 40 Greek COVID-19 patients (31 males, 9 females) with a median age of 59.50 ± 16.21 years were enrolled in the study. The median time from symptom onset to hospitalization was 8.0 ± 4.19 days. A significant negative correlation was observed between the SARS-CoV-2 Ag and total Ig levels. The temporal correlation patterns of the SARS-CoV-2 NP Ag and anti-S total Ig levels with laboratory markers varied among patients with differing degrees of COVID-19 severity. Severe-critical cases had lower SARS-CoV-2 Ag and increased total Ig levels as compared to mild-moderate cases. Conclusions. Distinct temporal profiles of the SARS-CoV-2 NP Ag and anti-S total Ig levels may distinguish different groups of COVID-19 severity. © 2021 Erasmia Rouka et al. | en |
dc.language.iso | en | en |
dc.source | Canadian Respiratory Journal | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116694398&doi=10.1155%2f2021%2f6590528&partnerID=40&md5=67b5550d8addacc7c8bd0ddaaa77586d | |
dc.subject | alanine aminotransferase | en |
dc.subject | C reactive protein | en |
dc.subject | coronavirus nucleocapsid protein | en |
dc.subject | coronavirus spike glycoprotein | en |
dc.subject | creatinine | en |
dc.subject | D dimer | en |
dc.subject | ferritin | en |
dc.subject | immunoglobulin A | en |
dc.subject | immunoglobulin G | en |
dc.subject | immunoglobulin M | en |
dc.subject | lactate dehydrogenase | en |
dc.subject | lactic acid | en |
dc.subject | SARS-CoV-2 antibody | en |
dc.subject | urea | en |
dc.subject | immunoglobulin | en |
dc.subject | virus antigen | en |
dc.subject | acute kidney failure | en |
dc.subject | adult | en |
dc.subject | adult respiratory distress syndrome | en |
dc.subject | aged | en |
dc.subject | Article | en |
dc.subject | cardiovascular disease | en |
dc.subject | clinical article | en |
dc.subject | cohort analysis | en |
dc.subject | coronavirus disease 2019 | en |
dc.subject | disease severity | en |
dc.subject | female | en |
dc.subject | hospital patient | en |
dc.subject | hospitalization | en |
dc.subject | human | en |
dc.subject | lateral flow immunochromatography | en |
dc.subject | length of stay | en |
dc.subject | leukocyte count | en |
dc.subject | lymphocyte count | en |
dc.subject | male | en |
dc.subject | multiple organ failure | en |
dc.subject | neutrophil count | en |
dc.subject | platelet count | en |
dc.subject | pneumonia | en |
dc.subject | prospective study | en |
dc.subject | real time reverse transcription polymerase chain reaction | en |
dc.subject | sensitivity and specificity | en |
dc.subject | Severe acute respiratory syndrome coronavirus 2 | en |
dc.subject | smoking | en |
dc.subject | enzyme linked immunosorbent assay | en |
dc.subject | epidemiology | en |
dc.subject | follow up | en |
dc.subject | Greece | en |
dc.subject | immunology | en |
dc.subject | middle aged | en |
dc.subject | pandemic | en |
dc.subject | very elderly | en |
dc.subject | virology | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Aged, 80 and over | en |
dc.subject | Antigens, Viral | en |
dc.subject | Coronavirus Nucleocapsid Proteins | en |
dc.subject | COVID-19 | en |
dc.subject | Enzyme-Linked Immunosorbent Assay | en |
dc.subject | Female | en |
dc.subject | Follow-Up Studies | en |
dc.subject | Greece | en |
dc.subject | Humans | en |
dc.subject | Immunoglobulins | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Pandemics | en |
dc.subject | Prospective Studies | en |
dc.subject | SARS-CoV-2 | en |
dc.subject | Hindawi Limited | en |
dc.title | Temporal Associations of the SARS-CoV-2 NP Antigen and Anti-Spike Total Ig Levels with Laboratory Parameters in a Greek Cohort of Hospitalized COVID-19 Patients | en |
dc.type | journalArticle | en |