dc.creator | Reyes F.M., Hache-Marliere M., Karamanis D., Berto C.G., Estrada R., Langston M., Ntaios G., Gulani P., Shah C.D., Palaiodimos L. | en |
dc.date.accessioned | 2023-01-31T09:51:26Z | |
dc.date.available | 2023-01-31T09:51:26Z | |
dc.date.issued | 2021 | |
dc.identifier | 10.3390/jcm10102087 | |
dc.identifier.issn | 20770383 | |
dc.identifier.uri | http://hdl.handle.net/11615/78498 | |
dc.description.abstract | Together, chronic obstructive pulmonary disease (COPD) and asthma account for the most common non-infectious respiratory pathologies. Conflicting preliminary studies have shown varied effect for COPD and asthma as prognostic factors for mortality in coronavirus disease 2019 (COVID-19). The aim of this study was to explore the association of COPD and asthma with in-hospital mortality in patients with COVID-19 by systematically reviewing and synthesizing with a meta-analysis the available observational studies. MEDLINE, Scopus, and medRxiv databases were reviewed. A random-effects model meta-analysis was used, and I-square was utilized to assess for heterogeneity. In-hospital mortality was defined as the primary endpoint. Sensitivity and meta-regression analyses were performed. Thirty studies with 21,309 patients were included in this meta-analysis (1465 with COPD and 633 with asthma). Hospitalized COVID-19 patients with COPD had higher risk of death compared to those without COPD (OR: 2.29; 95% CI: 1.79–2.93; I2 59.6%). No significant difference in in-hospital mortality was seen in patients with and without asthma (OR: 0.87; 95% CI: 0.68–1.10; I2 0.0%). The likelihood of death was significantly higher in patients with COPD that were hospitalized with COVID-19 compared to patients without COPD. Further studies are needed to assess whether this association is independent or not. No significant difference was demonstrated in COVID-19-related mortality between patients with and without asthma. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | en |
dc.language.iso | en | en |
dc.source | Journal of Clinical Medicine | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111283222&doi=10.3390%2fjcm10102087&partnerID=40&md5=eea73dcd8cc5784d08dd5040e73a7204 | |
dc.subject | adult | en |
dc.subject | age | en |
dc.subject | asthma | en |
dc.subject | chronic kidney failure | en |
dc.subject | chronic obstructive lung disease | en |
dc.subject | cohort analysis | en |
dc.subject | comorbidity | en |
dc.subject | comparative study | en |
dc.subject | coronary artery disease | en |
dc.subject | coronavirus disease 2019 | en |
dc.subject | death | en |
dc.subject | diabetes mellitus | en |
dc.subject | disease association | en |
dc.subject | female | en |
dc.subject | heart failure | en |
dc.subject | hospital patient | en |
dc.subject | human | en |
dc.subject | hypertension | en |
dc.subject | in-hospital mortality | en |
dc.subject | male | en |
dc.subject | Medline | en |
dc.subject | meta analysis | en |
dc.subject | mortality | en |
dc.subject | observational study | en |
dc.subject | Preferred Reporting Items for Systematic Reviews and Meta-Analyses | en |
dc.subject | Review | en |
dc.subject | Scopus | en |
dc.subject | sensitivity analysis | en |
dc.subject | Severe acute respiratory syndrome coronavirus 2 | en |
dc.subject | systematic review | en |
dc.subject | virus pathogenesis | en |
dc.subject | MDPI | en |
dc.title | Assessment of the association of copd and asthma with in-hospital mortality in patients with covid-19. A systematic review, meta-analysis, and meta-regression analysis | en |
dc.type | other | en |