Mostra i principali dati dell'item
The effect of a GnRH antagonist on follicle maturation in normal women
dc.creator | Pousias S., Messini C.I., Anifandis G., Sveronis G., Georgoulias P., Daponte A., Messinis I.E., Dafopoulos K. | en |
dc.date.accessioned | 2023-01-31T09:50:38Z | |
dc.date.available | 2023-01-31T09:50:38Z | |
dc.date.issued | 2019 | |
dc.identifier | 10.1016/j.rbmo.2019.03.100 | |
dc.identifier.issn | 14726483 | |
dc.identifier.uri | http://hdl.handle.net/11615/78353 | |
dc.description.abstract | Research question: Ganirelix is a gonadotrophin-releasing hormone (GnRH) antagonist used for the prevention of premature LH surge during ovarian stimulation. What is the impact of ganirelix on follicle maturation in normal women? Design: Ten normally cycling women were investigated during two menstrual cycles, i.e. cycle 1 (control) and cycle 2 (ganirelix). During both cycles, daily blood samples were taken from day 2, while transvaginal ultrasound scans were performed on cycle days 8 and 10 and daily thereafter. During cycle 2, all women were given 0.25 mg/day subcutaneous injections of the GnRH antagonist ganirelix from day 2 until the day of the endogenous LH surge onset in cycle 1. Results: During treatment with ganirelix, serum FSH and oestradiol concentrations remained stable, while those of LH decreased significantly on days 3, 4, 7 and 9 (P < 0.05) compared with controls. Nevertheless, there was no significant within-cycle variation in LH concentrations. From day 10 onwards, no follicle maturation was observed in cycle 2, in contrast to cycle 1. Ovulation occurred in 9 of 10 women in cycle 1. In cycle 2, ovulation was delayed by at least 1 week in eight women. Follicle growth and ovulation occurred in only one woman while on ganirelix treatment. Conclusions: This study demonstrates for the first time that in normal women dominant follicle selection failed during treatment with ganirelix. As there was a similar gonadotrophin profile in the two cycles, it is suggested that ganirelix interferes with the process of follicle selection by acting in the ovary. © 2019 | en |
dc.language.iso | en | en |
dc.source | Reproductive BioMedicine Online | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85065887401&doi=10.1016%2fj.rbmo.2019.03.100&partnerID=40&md5=f1ec7ef256d1033e47b906fed4e39789 | |
dc.subject | estradiol | en |
dc.subject | follitropin | en |
dc.subject | ganirelix | en |
dc.subject | luteinizing hormone | en |
dc.subject | estradiol | en |
dc.subject | follitropin | en |
dc.subject | ganirelix | en |
dc.subject | gonadorelin | en |
dc.subject | hormone antagonist | en |
dc.subject | luteinizing hormone | en |
dc.subject | adult | en |
dc.subject | Article | en |
dc.subject | clinical article | en |
dc.subject | controlled study | en |
dc.subject | estradiol blood level | en |
dc.subject | female | en |
dc.subject | follicular phase | en |
dc.subject | follitropin blood level | en |
dc.subject | human | en |
dc.subject | human cell | en |
dc.subject | luteinizing hormone blood level | en |
dc.subject | luteinizing hormone release | en |
dc.subject | menstrual cycle | en |
dc.subject | ovary follicle maturation | en |
dc.subject | ovulation | en |
dc.subject | transvaginal echography | en |
dc.subject | blood | en |
dc.subject | cell size | en |
dc.subject | clinical trial | en |
dc.subject | cytology | en |
dc.subject | dose response | en |
dc.subject | drug effect | en |
dc.subject | normal human | en |
dc.subject | ovary | en |
dc.subject | ovary follicle | en |
dc.subject | physiology | en |
dc.subject | subcutaneous drug administration | en |
dc.subject | young adult | en |
dc.subject | Adult | en |
dc.subject | Cell Size | en |
dc.subject | Dose-Response Relationship, Drug | en |
dc.subject | Estradiol | en |
dc.subject | Female | en |
dc.subject | Follicle Stimulating Hormone | en |
dc.subject | Follicular Phase | en |
dc.subject | Gonadotropin-Releasing Hormone | en |
dc.subject | Healthy Volunteers | en |
dc.subject | Hormone Antagonists | en |
dc.subject | Humans | en |
dc.subject | Injections, Subcutaneous | en |
dc.subject | Luteinizing Hormone | en |
dc.subject | Ovarian Follicle | en |
dc.subject | Ovary | en |
dc.subject | Ovulation | en |
dc.subject | Young Adult | en |
dc.subject | Elsevier Ltd | en |
dc.title | The effect of a GnRH antagonist on follicle maturation in normal women | en |
dc.type | journalArticle | en |
Files in questo item
Files | Dimensione | Formato | Mostra |
---|---|---|---|
Nessun files in questo item. |