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Vitamin C for the prevention of postoperative atrial fibrillation after cardiac surgery: A meta-analysis
dc.creator | Polymeropoulos E., Bagos P., Papadimitriou M., Rizos I., Patsouris E., Toumpoulis I. | en |
dc.date.accessioned | 2023-01-31T09:50:25Z | |
dc.date.available | 2023-01-31T09:50:25Z | |
dc.date.issued | 2016 | |
dc.identifier | 10.15171/apb.2016.033 | |
dc.identifier.issn | 22285881 | |
dc.identifier.uri | http://hdl.handle.net/11615/78307 | |
dc.description.abstract | Purpose: Several studies have investigated the administration of vitamin C (vitC) for the prevention of postoperative atrial fibrillation (AF) after cardiac surgery. However, their findings were inconsistent. The purpose of this meta-analysis was to evaluate the efficacy of vitC as prophylaxis for the prevention of postoperative AF in cardiac surgery. Methods: A systematic search of PubMed, EMBASE, Google Scholar, the Cochrane Library, and clinical trial registries, was performed. 9 studies, published from August 2001 to May 2015, were included, with a total of 1,037 patients. Patients were randomized to receive vitC, or placebo. Results: Cardiac surgery patients who received vitC as prophylaxis, had a significantly lower incidence of postoperative AF (random effects OR=0.478, 95% CI 0.340 - 0.673, P < 10-4). No significant heterogeneity was detected across the analyzed studies (I2=21.7%), and no publication bias or other small study-related bias was found. Conclusion: Our findings suggest that VitC is effective as prophylaxis for the prevention of postoperative AF. The administration of vitC may be considered in all patients undergoing cardiac surgery. © 2016 The Authors. | en |
dc.language.iso | en | en |
dc.source | Advanced Pharmaceutical Bulletin | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84980315604&doi=10.15171%2fapb.2016.033&partnerID=40&md5=068fa473f82c3389116d406376fa88a4 | |
dc.subject | ascorbic acid | en |
dc.subject | placebo | en |
dc.subject | Article | en |
dc.subject | atrial fibrillation | en |
dc.subject | drug efficacy | en |
dc.subject | heart surgery | en |
dc.subject | human | en |
dc.subject | incidence | en |
dc.subject | meta analysis | en |
dc.subject | postoperative atrial fibrillation | en |
dc.subject | postoperative complication | en |
dc.subject | systematic review | en |
dc.subject | Tabriz University of Medical Sciences | en |
dc.title | Vitamin C for the prevention of postoperative atrial fibrillation after cardiac surgery: A meta-analysis | en |
dc.type | journalArticle | en |
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