Increased triacylglycerol lipase activity in adipose tissue of lean and obese men during endurance exercise
dc.creator | Petridou A., Chatzinikolaou A., Avloniti A., Jamurtas A., Loules G., Papassotiriou I., Fatouros I., Mougios V. | en |
dc.date.accessioned | 2023-01-31T09:49:53Z | |
dc.date.available | 2023-01-31T09:49:53Z | |
dc.date.issued | 2017 | |
dc.identifier | 10.1210/jc.2017-00168 | |
dc.identifier.issn | 0021972X | |
dc.identifier.uri | http://hdl.handle.net/11615/78126 | |
dc.description.abstract | Context: Although there is increasing information on the mechanism of lipolysis in adipose tissue, the effect of exercise on individual factors of lipolysis is less well understood. Objective: Wecompared changes in adipose-tissue triacylglycerol lipase activity and gene expression of adipose triacylglycerol lipase (ATGL), hormone-sensitive lipase (HSL), monoacylglycerol lipase, perilipin 1, and comparative gene identification 58 (CGI-58) during exercise between lean and obese men. Design and Participants: Seven lean and nine obese men cycled for 30 minutes at a heart rate of 130 to 140 beats per minute. At baseline and 5, 10, 20, and 30 minutes of exercise, we sampled subcutaneous adipose tissue for triacylglycerol lipase activity and mRNA determination, and blood for glycerol, nonesterified fatty acid, glucose, lactate, insulin, and catecholamine determination. Setting: The study was conducted at a university research unit. Results: Triacylglycerol lipase activity increased at 10 minutes of exercise in the lean men and returned to baseline at 20 and 30 minutes. In the obese men, it was higher than baseline at 10, 20, and 30 minutes and higher than the corresponding values in the lean men at 20 and 30 minutes. No changes in mRNA levels were found during exercise, but the obese men had lower mRNA levels of ATGL, HSL, and CGI-58 compared with the lean men. Conclusion: Our findings suggest different patterns of lipolytic stimulation during endurance exercise between lean and obese men. Differences in lipolytic rates seem to be due to differences in protein amount or activity, notmRNA levels. © 2017 Endocrine Society. | en |
dc.language.iso | en | en |
dc.source | Journal of Clinical Endocrinology and Metabolism | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85030526771&doi=10.1210%2fjc.2017-00168&partnerID=40&md5=324c39747feb99268f6817564da24251 | |
dc.subject | acylglycerol lipase | en |
dc.subject | catecholamine | en |
dc.subject | comparative gene identification 58 | en |
dc.subject | fatty acid | en |
dc.subject | glucose | en |
dc.subject | glycerol | en |
dc.subject | hormone sensitive lipase | en |
dc.subject | insulin | en |
dc.subject | lactic acid | en |
dc.subject | lipid droplet associated protein | en |
dc.subject | messenger RNA | en |
dc.subject | perilipin 1 | en |
dc.subject | triacylglycerol lipase | en |
dc.subject | unclassified drug | en |
dc.subject | 1 acylglycerophosphate acyltransferase | en |
dc.subject | ABHD5 protein, human | en |
dc.subject | PNPLA2 protein, human | en |
dc.subject | triacylglycerol lipase | en |
dc.subject | adipose tissue | en |
dc.subject | adult | en |
dc.subject | Article | en |
dc.subject | blood sampling | en |
dc.subject | catecholamine blood level | en |
dc.subject | clinical article | en |
dc.subject | controlled study | en |
dc.subject | endurance training | en |
dc.subject | energy yield | en |
dc.subject | enzyme activity | en |
dc.subject | fatty acid blood level | en |
dc.subject | gene expression | en |
dc.subject | glucose blood level | en |
dc.subject | glycerol blood level | en |
dc.subject | heart rate | en |
dc.subject | human | en |
dc.subject | human tissue | en |
dc.subject | insulin blood level | en |
dc.subject | lactate blood level | en |
dc.subject | lean body weight | en |
dc.subject | lipolysis | en |
dc.subject | male | en |
dc.subject | obesity | en |
dc.subject | priority journal | en |
dc.subject | RNA analysis | en |
dc.subject | subcutaneous fat | en |
dc.subject | adipose tissue | en |
dc.subject | clinical trial | en |
dc.subject | comparative study | en |
dc.subject | endurance | en |
dc.subject | enzymology | en |
dc.subject | exercise | en |
dc.subject | genetics | en |
dc.subject | kinesiotherapy | en |
dc.subject | metabolism | en |
dc.subject | obesity | en |
dc.subject | physiology | en |
dc.subject | procedures | en |
dc.subject | underweight | en |
dc.subject | young adult | en |
dc.subject | 1-Acylglycerol-3-Phosphate O-Acyltransferase | en |
dc.subject | Adipose Tissue | en |
dc.subject | Adult | en |
dc.subject | Exercise | en |
dc.subject | Exercise Therapy | en |
dc.subject | Humans | en |
dc.subject | Lipase | en |
dc.subject | Male | en |
dc.subject | Obesity | en |
dc.subject | Physical Endurance | en |
dc.subject | Thinness | en |
dc.subject | Young Adult | en |
dc.subject | Oxford University Press | en |
dc.title | Increased triacylglycerol lipase activity in adipose tissue of lean and obese men during endurance exercise | en |
dc.type | journalArticle | en |
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