dc.creator | Perlepe G., Varsamas C., Petinaki E., Antonopoulos D., Daniil Z., Gourgoulianis K.I. | en |
dc.date.accessioned | 2023-01-31T09:47:33Z | |
dc.date.available | 2023-01-31T09:47:33Z | |
dc.date.issued | 2021 | |
dc.identifier | 10.3390/jpm11090864 | |
dc.identifier.issn | 20754426 | |
dc.identifier.uri | http://hdl.handle.net/11615/78078 | |
dc.description.abstract | (1) Background: Malignant (MPE), parapneumonic (PPE) and tuberculous (TPE) pleural effusions constitute common causes of pleurisy. Discriminating among them is usually challenging. C-reactive protein (CRP) and adenosine deaminase (ADA) pleural levels (p-CRP, p-ADA) have been used as differentiators in many studies showing promising results. This study aims to evaluate the diagnostic value of p-CRP, p-ADA levels and their combination among the three categories. (2) Methods: A prospective study of 100 patients with MPE (n = 59), PPE (n = 34) and TPE (n = 7) from a single centre was performed. p-CRP levels were evaluated between PPE and non-PPE and between complicated (CPPE) and non-complicated PPE. ADA levels were also measured to classify patients among MPE and non-MPE. Eventually, the combination of p-CRP and p-ADA values was used as a discrimination factor among PPE, MPE and TPE. (3) Results: ROC analysis revealed that p-CRP with a cut-off value: 4.4 mg/dL can successfully differentiate PPE (AUC = 0.998). The cut-off level of 10 mg/dL can predict CPPE with sensitivity: 63%, specificity: 71.4%, positive predictive value (PPV): 89%, and negative predictive value (NPV): 33%. Furthermore, patients with ADA levels ≤ 32 U/L were more likely to belong to the malignant group sensitivity: 93%, specificity: 78%, PPV: 85.9%, and NPV: 88.9%. Discriminant analysis showed that the combination of p-CRP and p-ADA levels can discriminate PPE, MPE and TPE in 93% of cases. (4) Conclusion: This study provides evidence that p-CRP and p-ADA levels could be possibly used in clinal practice in order to establish a diagnosis among MPE, PPE and TPE. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | en |
dc.language.iso | en | en |
dc.source | Journal of Personalized Medicine | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114496021&doi=10.3390%2fjpm11090864&partnerID=40&md5=bb2215e23b2f9ba4ffd753010c482f98 | |
dc.subject | adenosine deaminase | en |
dc.subject | albumin | en |
dc.subject | alkaline phosphatase | en |
dc.subject | C reactive protein | en |
dc.subject | glucose | en |
dc.subject | lactate dehydrogenase | en |
dc.subject | protein | en |
dc.subject | adult | en |
dc.subject | aged | en |
dc.subject | Article | en |
dc.subject | complicated parapneumonic pleural effusion | en |
dc.subject | computer assisted tomography | en |
dc.subject | controlled study | en |
dc.subject | cytology | en |
dc.subject | diagnostic accuracy | en |
dc.subject | diagnostic test accuracy study | en |
dc.subject | diagnostic value | en |
dc.subject | discriminant analysis | en |
dc.subject | echography | en |
dc.subject | empyema | en |
dc.subject | epithelioid histiocyte | en |
dc.subject | extrapulmonary tuberculosis | en |
dc.subject | female | en |
dc.subject | hospitalization | en |
dc.subject | human | en |
dc.subject | human tissue | en |
dc.subject | immunoturbidimetry | en |
dc.subject | international normalized ratio | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | malignant pleura effusion | en |
dc.subject | middle aged | en |
dc.subject | Mycobacterium tuberculosis | en |
dc.subject | observational study | en |
dc.subject | pH | en |
dc.subject | photometry | en |
dc.subject | pleura biopsy | en |
dc.subject | pleura effusion | en |
dc.subject | pleura fluid | en |
dc.subject | predictive value | en |
dc.subject | prospective study | en |
dc.subject | receiver operating characteristic | en |
dc.subject | sensitivity and specificity | en |
dc.subject | thoracocentesis | en |
dc.subject | tuberculous pleurisy | en |
dc.subject | MDPI | en |
dc.title | Discrimination of exudative pleural effusions based on pleural adenosine deaminase (Ada)-c-reactive protein (crp) levels, and their combination: An observational prospective study | en |
dc.type | journalArticle | en |