dc.creator | Paltoglou G., Schoina M., Valsamakis G., Salakos N., Avloniti A., Chatzinikolaou A., Margeli A., Skevaki C., Papagianni M., Kanaka-Gantenbein C., Papassotiriou I., Chrousos G.P., Fatouros I.G., Mastorakos G. | en |
dc.date.accessioned | 2023-01-31T09:41:25Z | |
dc.date.available | 2023-01-31T09:41:25Z | |
dc.date.issued | 2017 | |
dc.identifier | 10.1007/s12020-017-1227-3 | |
dc.identifier.issn | 1355008X | |
dc.identifier.uri | http://hdl.handle.net/11615/77442 | |
dc.description.abstract | Purpose: Presumed interrelationships among deleterious aspects of adipose tissue metabolism, inflammation, and cellular oxidative stress could be influenced by pubertal hormonal changes. They were investigated in pre- and early pubertal normal-weight and obese boys before and after an exercise bout employed as an energy demanding stimulator. Methods: Cross-sectional study. Seventy-six healthy pre- (mean ± SD, 10.6 ± 0.2 years old, 28 normal-weight, and 11 obese) and early-(11.4 ± 0.2 years old, 25 normal-weight, and 12 obese) pubertal boys, were blood-sampled before and after a bout of exercise at 70% VO2 max. Leptin, adiponectin, markers of inflammation (high-sensitivity C-reactive protein, high sensitivity IL-6), pro- (thiobarbitouric acid reactive substances, protein carbonyls) and anti- (glutathione, oxidized glutathione, glutathione peroxidase, catalase, total antioxidant capacity) oxidation were measured. Results: Baseline and post-exercise adiponectin was greater and leptin and high-sensitivity C-reactive protein were lower in normal-weight than in obese pre- and early pubertal boys, while high sensitivity IL-6 was greater in obese than in normal-weight pre-pubertal boys. In pre-pubertal obese boys: at baseline, high-sensitivity C-reactive protein correlated negatively with catalase; high sensitivity IL-6 correlated positively with protein carbonyls; Δ (difference during exercise) adiponectin correlated positively with Δcatalase. In all boys: at baseline, high sensitivity IL-6 correlated positively with leptin and was the best negative and the second best positive predictor for post-exercise glutathione/oxidized glutathione and protein carbonyls, respectively; leptin was the best negative predictor for post-exercise glutathione; waist to height ratio was the best positive predictor for post-exercise thiobarbitouric acid reactive substances; body mass index z-score and adiponectin were, respectively, the best positive predictor for post-exercise protein carbonyls and catalase. Conclusions: In all subjects, leptin and adiponectin predict negatively and positively anti-oxidation, respectively, while high sensitivity IL-6 predicts positively and negatively pro- and anti-oxidation, respectively. High-sensitivity C-reactive protein is increased and negatively associated with anti-oxidation in pre-pubertal obese boys, suggesting that childhood obesity is associated with aseptic inflammation and oxidative stress. © 2017, Springer Science+Business Media New York. | en |
dc.language.iso | en | en |
dc.source | Endocrine | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009476816&doi=10.1007%2fs12020-017-1227-3&partnerID=40&md5=c54d32d85b02cf9605952ffd328efbb8 | |
dc.subject | adiponectin | en |
dc.subject | C reactive protein | en |
dc.subject | carbonyl derivative | en |
dc.subject | catalase | en |
dc.subject | glutathione | en |
dc.subject | glutathione disulfide | en |
dc.subject | glutathione peroxidase | en |
dc.subject | interleukin 6 | en |
dc.subject | leptin | en |
dc.subject | thiobarbituric acid reactive substance | en |
dc.subject | adiponectin | en |
dc.subject | biological marker | en |
dc.subject | C reactive protein | en |
dc.subject | interleukin 6 | en |
dc.subject | leptin | en |
dc.subject | aerobic exercise | en |
dc.subject | antioxidant activity | en |
dc.subject | Article | en |
dc.subject | blood sampling | en |
dc.subject | body mass | en |
dc.subject | child | en |
dc.subject | clinical article | en |
dc.subject | concentration (parameters) | en |
dc.subject | controlled study | en |
dc.subject | cross-sectional study | en |
dc.subject | human | en |
dc.subject | inflammation | en |
dc.subject | male | en |
dc.subject | obesity | en |
dc.subject | oxidation | en |
dc.subject | oxidative stress | en |
dc.subject | prepuberty | en |
dc.subject | scoring system | en |
dc.subject | sensitivity analysis | en |
dc.subject | tissue metabolism | en |
dc.subject | waist hip ratio | en |
dc.subject | waist to height ratio | en |
dc.subject | z score | en |
dc.subject | blood | en |
dc.subject | exercise | en |
dc.subject | inflammation | en |
dc.subject | metabolism | en |
dc.subject | obesity | en |
dc.subject | oxidative stress | en |
dc.subject | physiology | en |
dc.subject | puberty | en |
dc.subject | Adiponectin | en |
dc.subject | Biomarkers | en |
dc.subject | C-Reactive Protein | en |
dc.subject | Child | en |
dc.subject | Exercise | en |
dc.subject | Humans | en |
dc.subject | Inflammation | en |
dc.subject | Interleukin-6 | en |
dc.subject | Leptin | en |
dc.subject | Male | en |
dc.subject | Obesity | en |
dc.subject | Oxidative Stress | en |
dc.subject | Puberty | en |
dc.subject | Humana Press Inc. | en |
dc.title | Interrelations among the adipocytokines leptin and adiponectin, oxidative stress and aseptic inflammation markers in pre- and early-pubertal normal-weight and obese boys | en |
dc.type | journalArticle | en |