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The effect of in-hospital acquired thrombocytopenia on the outcome of patients with acute coronary syndromes: A systematic review and meta-analysis
dc.creator | Oikonomou E.K., Repanas T.I., Papanastasiou C., Kokkinidis D.G., Miligkos M., Feher A., Gupta D., Kampaktsis P.N. | en |
dc.date.accessioned | 2023-01-31T09:41:01Z | |
dc.date.available | 2023-01-31T09:41:01Z | |
dc.date.issued | 2016 | |
dc.identifier | 10.1016/j.thromres.2016.09.026 | |
dc.identifier.issn | 00493848 | |
dc.identifier.uri | http://hdl.handle.net/11615/77375 | |
dc.description.abstract | Background In-hospital acquired thrombocytopenia (TP) is relatively common among patients hospitalized with acute coronary syndromes (ACS). However, its effect on short-term and long-term outcomes has yet to be reviewed systematically. Methods We conducted a systematic review and meta-analysis of clinical studies assessing the relationship between new-onset in-hospital TP and adverse outcomes among ACS patients. MEDLINE, Scopus and the Cochrane Library were searched for eligible studies published before March 20, 2016. Results Ten studies reporting on a total of 142,161 ACS patients were identified. 8133 patients showed evidence of new-onset TP during the course of their hospitalization. Compared with patients with normal platelet counts, patients with new-onset TP had a prolonged in-hospital stay, significantly higher risk of both short-term mortality (< 30 days) (Odds ratio (OR) [95% confidence interval (CI)]: 5.58 [3.63–8.57]) and late death (6 months to 1 year) (OR [95% CI]: 3.45 [2.35–5.07]), as well as a significantly higher risk of major bleeding events in the first 30 days (OR [95% CI]: 6.93 [5.13–9.38]). In addition, risk for other secondary cardiovascular endpoints, including recurrent myocardial infarction, stroke, in-hospital heart failure, stent thrombosis and unplanned revascularization was also significantly higher in the TP versus the no TP group. Conclusions Development of TP during the in-hospital management of ACS patients is a significant predictor of both short- and long-term adverse events, including mortality. In the light of this evidence, clinicians should be cautious and closely monitor abnormal platelet counts that present early following an ACS. © 2016 Elsevier Ltd | en |
dc.language.iso | en | en |
dc.source | Thrombosis Research | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84988812034&doi=10.1016%2fj.thromres.2016.09.026&partnerID=40&md5=4382c26ae0acdce678371c3f75c187b5 | |
dc.subject | acute coronary syndrome | en |
dc.subject | adverse outcome | en |
dc.subject | Article | en |
dc.subject | bleeding | en |
dc.subject | cardiovascular risk | en |
dc.subject | cerebrovascular accident | en |
dc.subject | heart failure | en |
dc.subject | heart infarction | en |
dc.subject | hospitalization | en |
dc.subject | human | en |
dc.subject | mortality rate | en |
dc.subject | priority journal | en |
dc.subject | revascularization | en |
dc.subject | stent thrombosis | en |
dc.subject | thrombocyte count | en |
dc.subject | thrombocytopenia | en |
dc.subject | acute coronary syndrome | en |
dc.subject | complication | en |
dc.subject | Hemorrhage | en |
dc.subject | meta analysis | en |
dc.subject | mortality | en |
dc.subject | risk | en |
dc.subject | thrombocytopenia | en |
dc.subject | Acute Coronary Syndrome | en |
dc.subject | Hemorrhage | en |
dc.subject | Hospitalization | en |
dc.subject | Humans | en |
dc.subject | Platelet Count | en |
dc.subject | Risk | en |
dc.subject | Thrombocytopenia | en |
dc.subject | Elsevier Ltd | en |
dc.title | The effect of in-hospital acquired thrombocytopenia on the outcome of patients with acute coronary syndromes: A systematic review and meta-analysis | en |
dc.type | journalArticle | en |
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