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On the immunoregulatory role of statins in multiple sclerosis: the effects on Th17 cells
dc.creator | Ntolkeras G., Barba C., Mavropoulos A., Vasileiadis G.K., Dardiotis E., Sakkas L.I., Hadjigeorgiou G., Bogdanos D.P. | en |
dc.date.accessioned | 2023-01-31T09:40:55Z | |
dc.date.available | 2023-01-31T09:40:55Z | |
dc.date.issued | 2019 | |
dc.identifier | 10.1007/s12026-019-09089-5 | |
dc.identifier.issn | 0257277X | |
dc.identifier.uri | http://hdl.handle.net/11615/77356 | |
dc.description.abstract | Statins, the cholesterol-lowering drugs, also possess immunomodulatory properties, affecting among others T cell activation and differentiation, antigen presentation, and regulatory T cell (Tregs) maintenance and differentiation. Their effects on autoagression have led investigators to assess their clinical significance in autoimmune disease, such as multiple sclerosis (MS), a chronic progressive demyelinating disease of autoimmune nature. The dysregulated immunity noted in MS features a profound shift from Tregs dominance to Th17 cell superiority. In this review, we discuss the immunobiological basis of statins, their role in autoimmunity related to MS, and the data from experimental models and human studies on their effect on Th17 cells. © 2019, Springer Science+Business Media, LLC, part of Springer Nature. | en |
dc.language.iso | en | en |
dc.source | Immunologic Research | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85070384619&doi=10.1007%2fs12026-019-09089-5&partnerID=40&md5=5f5564b2ddf4451cb4f49115654bef23 | |
dc.subject | alpha2 integrin | en |
dc.subject | atorvastatin | en |
dc.subject | beta interferon | en |
dc.subject | CD39 antigen | en |
dc.subject | cerivastatin | en |
dc.subject | cytotoxic T lymphocyte antigen 4 | en |
dc.subject | ezetimibe | en |
dc.subject | fluindostatin | en |
dc.subject | gelatinase A | en |
dc.subject | gelatinase B | en |
dc.subject | hepatitis A virus cellular receptor 2 | en |
dc.subject | interleukin 10 | en |
dc.subject | interleukin 17 | en |
dc.subject | interleukin 2 receptor alpha | en |
dc.subject | interleukin 21 | en |
dc.subject | interleukin 23 | en |
dc.subject | interleukin 35 | en |
dc.subject | interleukin 6 | en |
dc.subject | lymphocyte activation protein 3 | en |
dc.subject | lymphocyte receptor | en |
dc.subject | mevinolin | en |
dc.subject | programmed death 1 receptor | en |
dc.subject | rosuvastatin | en |
dc.subject | simvastatin | en |
dc.subject | Smad2 protein | en |
dc.subject | Smad3 protein | en |
dc.subject | STAT5 protein | en |
dc.subject | transcription factor FOXP3 | en |
dc.subject | transforming growth factor beta | en |
dc.subject | unclassified drug | en |
dc.subject | unindexed drug | en |
dc.subject | hydroxymethylglutaryl coenzyme A reductase inhibitor | en |
dc.subject | immunologic factor | en |
dc.subject | apoptosis | en |
dc.subject | CD4+ CD25+ T lymphocyte | en |
dc.subject | CD8+ T lymphocyte | en |
dc.subject | cell migration | en |
dc.subject | cytokine production | en |
dc.subject | cytokine release | en |
dc.subject | down regulation | en |
dc.subject | enzyme inhibition | en |
dc.subject | human | en |
dc.subject | immunobiology | en |
dc.subject | immunoregulation | en |
dc.subject | in vitro study | en |
dc.subject | lymphocyte differentiation | en |
dc.subject | lymphocyte proliferation | en |
dc.subject | multiple sclerosis | en |
dc.subject | nonhuman | en |
dc.subject | pathogenesis | en |
dc.subject | priority journal | en |
dc.subject | protein expression | en |
dc.subject | protein targeting | en |
dc.subject | regulatory T lymphocyte | en |
dc.subject | Review | en |
dc.subject | T lymphocyte activation | en |
dc.subject | Th1 cell | en |
dc.subject | Th17 cell | en |
dc.subject | upregulation | en |
dc.subject | animal | en |
dc.subject | disease model | en |
dc.subject | immunology | en |
dc.subject | multiple sclerosis | en |
dc.subject | pathology | en |
dc.subject | Th17 cell | en |
dc.subject | Animals | en |
dc.subject | Disease Models, Animal | en |
dc.subject | Humans | en |
dc.subject | Hydroxymethylglutaryl-CoA Reductase Inhibitors | en |
dc.subject | Immunologic Factors | en |
dc.subject | Multiple Sclerosis | en |
dc.subject | Th17 Cells | en |
dc.subject | Springer | en |
dc.title | On the immunoregulatory role of statins in multiple sclerosis: the effects on Th17 cells | en |
dc.type | other | en |
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