Viruses and Multiple Sclerosis: From Mechanisms and Pathways to Translational Research Opportunities
dc.creator | Mentis A.-F.A., Dardiotis E., Grigoriadis N., Petinaki E., Hadjigeorgiou G.M. | en |
dc.date.accessioned | 2023-01-31T08:59:06Z | |
dc.date.available | 2023-01-31T08:59:06Z | |
dc.date.issued | 2017 | |
dc.identifier | 10.1007/s12035-017-0530-6 | |
dc.identifier.issn | 08937648 | |
dc.identifier.uri | http://hdl.handle.net/11615/76541 | |
dc.description.abstract | Viruses are directly or indirectly implicated in multiple sclerosis (MS). Here, we review the evidence on the virus-related pathophysiology of MS, introduce common experimental models, and explore the ways in which viruses cause demyelination. By emphasizing knowledge gaps, we highlight future research directions for effective MS diagnostics and therapies: (i) identifying biomarkers for at-risk individuals, (ii) searching for direct evidence of specific causative viruses, (iii) establishing the contribution of host genetic factors and viruses, and (iv) investigating the contribution of immune regulation at extra-CNS sites. Research in these areas is likely to be facilitated by the application of high-throughput technologies, the development of systems-based bioinformatic approaches, careful selection of experimental models, and the acquisition of high-quality clinical material for tissue-based research. © 2017, Springer Science+Business Media New York. | en |
dc.language.iso | en | en |
dc.source | Molecular Neurobiology | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85018284399&doi=10.1007%2fs12035-017-0530-6&partnerID=40&md5=1218f4009736c36c3c32c7049a5817c6 | |
dc.subject | alemtuzumab | en |
dc.subject | beta1a interferon | en |
dc.subject | daclizumab | en |
dc.subject | epitope | en |
dc.subject | fingolimod | en |
dc.subject | fumaric acid dimethyl ester | en |
dc.subject | interferon beta serine | en |
dc.subject | monoclonal antibody | en |
dc.subject | natalizumab | en |
dc.subject | teriflunomide | en |
dc.subject | virus envelope protein | en |
dc.subject | acute disseminated encephalomyelitis | en |
dc.subject | autoimmunity | en |
dc.subject | bioinformatics | en |
dc.subject | bystander effect | en |
dc.subject | demyelination | en |
dc.subject | endogenous retrovirus | en |
dc.subject | epitope spreading | en |
dc.subject | experimental autoimmune encephalomyelitis | en |
dc.subject | fertile field theory | en |
dc.subject | human | en |
dc.subject | Human T-lymphotropic virus 1 | en |
dc.subject | immunomodulation | en |
dc.subject | induced pluripotent stem cell | en |
dc.subject | intestine flora | en |
dc.subject | JC virus | en |
dc.subject | molecular mimicry | en |
dc.subject | multiple sclerosis | en |
dc.subject | Murine hepatitis virus | en |
dc.subject | next generation sequencing | en |
dc.subject | nonhuman | en |
dc.subject | progressive multifocal leukoencephalopathy | en |
dc.subject | Review | en |
dc.subject | Semliki Forest virus | en |
dc.subject | subacute sclerosing panencephalitis | en |
dc.subject | Theiler's murine encephalomyelitis virus | en |
dc.subject | theory | en |
dc.subject | translational research | en |
dc.subject | virus | en |
dc.subject | virus cell interaction | en |
dc.subject | animal | en |
dc.subject | biological model | en |
dc.subject | disease exacerbation | en |
dc.subject | disease model | en |
dc.subject | metabolism | en |
dc.subject | multiple sclerosis | en |
dc.subject | pathology | en |
dc.subject | pathophysiology | en |
dc.subject | stem cell | en |
dc.subject | translational research | en |
dc.subject | virology | en |
dc.subject | Animals | en |
dc.subject | Disease Models, Animal | en |
dc.subject | Disease Progression | en |
dc.subject | Humans | en |
dc.subject | Models, Biological | en |
dc.subject | Multiple Sclerosis | en |
dc.subject | Stem Cells | en |
dc.subject | Translational Medical Research | en |
dc.subject | Humana Press Inc. | en |
dc.title | Viruses and Multiple Sclerosis: From Mechanisms and Pathways to Translational Research Opportunities | en |
dc.type | other | en |
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