dc.creator | Mendrinou E., Patsatsi A., Zafiriou E., Papadopoulou D., Aggelou L., Sarri C., Mamuris Z., Kyriakou A., Sotiriadis D., Roussaki-Schulze A., Sarafidou T., Vasilopoulos Y. | en |
dc.date.accessioned | 2023-01-31T08:58:52Z | |
dc.date.available | 2023-01-31T08:58:52Z | |
dc.date.issued | 2017 | |
dc.identifier | 10.1038/tpj.2016.16 | |
dc.identifier.issn | 1470269X | |
dc.identifier.uri | http://hdl.handle.net/11615/76516 | |
dc.description.abstract | Psoriasis is a multifactorial skin disease affecting ∼2% of world's population, causing a dramatic decrease in patients' quality of life and a significant increase in health-care expenses. Biological agents such as the anti-TNFα ones had an enormous impact in patients' therapy; however, a significant proportion of them do not respond well, an outcome attributed mainly to genetic factors. Recently, in a large European cohort of rheumatoid arthritis patients we have shown association with variation in the receptors that correspond to the Fc portion of the biological agents. As both diseases share common immunological fingerprints, we examined the hypothesis that they share common pharmacogenetic markers. Analysis of FCGR2A-H131R and FCGR3A-V158F polymorphisms in 100 psoriasis patients showed association only with respect to FCGR3A-V158F and response to etanercept (P=0.018). Interestingly, no association was found between FCGR2A-H131R and response to anti-TNFα therapy (P=0.882). This study suggests a role for FCGR3A-V158F polymorphism unique for psoriasis. © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. | en |
dc.language.iso | en | en |
dc.source | Pharmacogenomics Journal | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84962657826&doi=10.1038%2ftpj.2016.16&partnerID=40&md5=ff02a8e2c1bebd8d7978ba3d9a1ffce8 | |
dc.subject | etanercept | en |
dc.subject | tumor necrosis factor inhibitor | en |
dc.subject | antiinflammatory agent | en |
dc.subject | etanercept | en |
dc.subject | Fc receptor | en |
dc.subject | FCGR3A protein, human | en |
dc.subject | immunoglobulin Fc fragment | en |
dc.subject | tumor necrosis factor | en |
dc.subject | adult | en |
dc.subject | Article | en |
dc.subject | cohort analysis | en |
dc.subject | comorbidity | en |
dc.subject | controlled study | en |
dc.subject | disease association | en |
dc.subject | disease duration | en |
dc.subject | disease severity | en |
dc.subject | DNA polymorphism | en |
dc.subject | drug response | en |
dc.subject | FCGR3A gene | en |
dc.subject | female | en |
dc.subject | gene function | en |
dc.subject | genetic analysis | en |
dc.subject | genetic marker | en |
dc.subject | human | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | onset age | en |
dc.subject | pharmacogenetics | en |
dc.subject | priority journal | en |
dc.subject | psoariasis area and severity index | en |
dc.subject | psoriasis | en |
dc.subject | scoring system | en |
dc.subject | antagonists and inhibitors | en |
dc.subject | drug effects | en |
dc.subject | drug resistance | en |
dc.subject | genetics | en |
dc.subject | genotype | en |
dc.subject | immunology | en |
dc.subject | middle aged | en |
dc.subject | pharmacogenetic testing | en |
dc.subject | pharmacogenetic variant | en |
dc.subject | pharmacogenetics | en |
dc.subject | phenotype | en |
dc.subject | psoriasis | en |
dc.subject | retrospective study | en |
dc.subject | single nucleotide polymorphism | en |
dc.subject | treatment outcome | en |
dc.subject | Adult | en |
dc.subject | Anti-Inflammatory Agents | en |
dc.subject | Drug Resistance | en |
dc.subject | Etanercept | en |
dc.subject | Female | en |
dc.subject | Genotype | en |
dc.subject | Humans | en |
dc.subject | Immunoglobulin Fc Fragments | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Pharmacogenetics | en |
dc.subject | Pharmacogenomic Testing | en |
dc.subject | Pharmacogenomic Variants | en |
dc.subject | Phenotype | en |
dc.subject | Polymorphism, Single Nucleotide | en |
dc.subject | Psoriasis | en |
dc.subject | Receptors, IgG | en |
dc.subject | Retrospective Studies | en |
dc.subject | Treatment Outcome | en |
dc.subject | Tumor Necrosis Factor-alpha | en |
dc.subject | Nature Publishing Group | en |
dc.title | FCGR3A-V158F polymorphism is a disease-specific pharmacogenetic marker for the treatment of psoriasis with Fc-containing TNFα inhibitors | en |
dc.type | journalArticle | en |