Mostra i principali dati dell'item
IL-10 producing Bregs are impaired in psoriatic arthritis and psoriasis and inversely correlate with IL-17- and IFNγ-producing T cells
dc.creator | Mavropoulos A., Varna A., Zafiriou E., Liaskos C., Alexiou I., Roussaki-Schulze A., Vlychou M., Katsiari C., Bogdanos D.P., Sakkas L.I. | en |
dc.date.accessioned | 2023-01-31T08:58:11Z | |
dc.date.available | 2023-01-31T08:58:11Z | |
dc.date.issued | 2017 | |
dc.identifier | 10.1016/j.clim.2017.04.010 | |
dc.identifier.issn | 15216616 | |
dc.identifier.uri | http://hdl.handle.net/11615/76445 | |
dc.description.abstract | Our aim was to study CD19(+)CD27(+)CD24(high) memory and CD19(+)CD24(high)CD38(high) transitional and IL-10 + Breg cells, known to inhibit Th1 and Th17 cells in experimental arthritis, in psoriatic arthritis (PsA) and psoriasis (Ps). Peripheral blood Breg cells from 60 patients with PsA, 50 patients with Ps and 23 healthy controls were analyzed by flow cytometry. IL-17A-producing CD3(+) T cells and IFNγ-producing CD3(+) T cells and activation of p38 MAPK and STAT3 were also studied. CD19(+)CD27(+)CD24(high) and CD19(+)CD24(high)CD38(high) Breg cells were decreased in PsA and Ps. In Ps patients, CD19(+)CD27(+)CD24(high) Breg cells inversely correlated with PASI score. IL-10 + Bcells were also decreased and inversely correlated with IL-17A + CD3 + and IFN-γ + CD3 + T cells. B cells from patients exhibited impaired activation of p38 MAPK and STAT3. In conclusion, IL-10 + Breg cells are decreased PsA and Ps and inversely correlated with the severity of psoriasis and IL-17A + and IFNγ + T cells. © 2017 Elsevier Inc. | en |
dc.language.iso | en | en |
dc.source | Clinical Immunology | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85018311622&doi=10.1016%2fj.clim.2017.04.010&partnerID=40&md5=8f96b5ff52733198fd38b16dcfe9a1f4 | |
dc.subject | CD19 antigen | en |
dc.subject | CD24 antigen | en |
dc.subject | CD27 antigen | en |
dc.subject | CD38 antigen | en |
dc.subject | gamma interferon | en |
dc.subject | interleukin 10 | en |
dc.subject | interleukin 12 | en |
dc.subject | interleukin 17 | en |
dc.subject | interleukin 23 | en |
dc.subject | mitogen activated protein kinase p38 | en |
dc.subject | STAT3 protein | en |
dc.subject | antirheumatic agent | en |
dc.subject | CD3 antigen | en |
dc.subject | gamma interferon | en |
dc.subject | IFNG protein, human | en |
dc.subject | IL10 protein, human | en |
dc.subject | interleukin 10 | en |
dc.subject | interleukin 17 | en |
dc.subject | mitogen activated protein kinase p38 | en |
dc.subject | STAT3 protein | en |
dc.subject | STAT3 protein, human | en |
dc.subject | adult | en |
dc.subject | Article | en |
dc.subject | blood sampling | en |
dc.subject | cell differentiation | en |
dc.subject | comparative study | en |
dc.subject | controlled study | en |
dc.subject | female | en |
dc.subject | flow cytometry | en |
dc.subject | human | en |
dc.subject | human cell | en |
dc.subject | immunofluorescence | en |
dc.subject | lymphocyte subpopulation | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | middle aged | en |
dc.subject | peripheral blood mononuclear cell | en |
dc.subject | priority journal | en |
dc.subject | Psoriasis Area and Severity Index | en |
dc.subject | psoriatic arthritis | en |
dc.subject | regulatory B lymphocyte | en |
dc.subject | T lymphocyte | en |
dc.subject | Th1 cell | en |
dc.subject | Th17 cell | en |
dc.subject | aged | en |
dc.subject | immunology | en |
dc.subject | metabolism | en |
dc.subject | psoriasis | en |
dc.subject | psoriatic arthritis | en |
dc.subject | regulatory B lymphocyte | en |
dc.subject | severity of illness index | en |
dc.subject | T lymphocyte | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Antirheumatic Agents | en |
dc.subject | Arthritis, Psoriatic | en |
dc.subject | B-Lymphocytes, Regulatory | en |
dc.subject | CD3 Complex | en |
dc.subject | Female | en |
dc.subject | Flow Cytometry | en |
dc.subject | Humans | en |
dc.subject | Interferon-gamma | en |
dc.subject | Interleukin-10 | en |
dc.subject | Interleukin-17 | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | p38 Mitogen-Activated Protein Kinases | en |
dc.subject | Psoriasis | en |
dc.subject | Severity of Illness Index | en |
dc.subject | STAT3 Transcription Factor | en |
dc.subject | T-Lymphocytes | en |
dc.subject | Academic Press Inc. | en |
dc.title | IL-10 producing Bregs are impaired in psoriatic arthritis and psoriasis and inversely correlate with IL-17- and IFNγ-producing T cells | en |
dc.type | journalArticle | en |
Files in questo item
Files | Dimensione | Formato | Mostra |
---|---|---|---|
Nessun files in questo item. |