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Increased immunoreactivity against human cytomegalovirus UL83 in systemic sclerosis
dc.creator | Marou E., Liaskos C., Efthymiou G., Dardiotis E., Daponte A., Scheper T., Meyer W., Hadjigeorgiou G., Bogdanos D.P., Sakkas L.I. | en |
dc.date.accessioned | 2023-01-31T08:57:44Z | |
dc.date.available | 2023-01-31T08:57:44Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0392856X | |
dc.identifier.uri | http://hdl.handle.net/11615/76392 | |
dc.description.abstract | Objective. To study immunoreactivity against human cytomegalovirus (HCMV) in systemic sclerosis (SSc), since HCMV has been put forward as a candidate infectious cause. Methods. Eighty four patients with SSc (67 females; median age 60 years, range 25-81), 30 patients with multiple sclerosis (MS) (23 females; median age 44, range 20-69 years) and 28 healthy controls (NCs), all pre-tested positive for IgG anti-HCMV antibodies, were studied. IgG anti-UL83 HCMV antibodies were tested by western immunoblotting and expressed in arbitrary units (AUs). Reactivity to UL83 HCMV was assessed in relation to clinical manifestations and SSc-related autoantibodies (autoAbs), tested by an IgG SSc autoantibody profile line immunoassay (Euroimmun) that detects autoAbs against Scl-70, CENPA, CENPB, RNA polymerase III subunit 11 (RP11), RP155, fibrillarin, NOR90, Th/To, PM-Scl100, PM-Scl75, Ku, PDGFR and Ro-52. Results. Fifty patients (59.5%) were anti-UL83 clear positive (UL83+), including 21/40 (52.5%) lcSSc and 29/44 (65.6%) dcSSc, compared to 15/30 (50%) patients with MS (SSc vs MS, p=ns and 11/28 (39.29%) of NCs (SSc vs NC, p=ns MS vs NC, p=ns). Anti- UL83 antibody AU levels (mean±SD) were higher in SSc (64.3 ± 26) compared to MS (49.1±21.6, p=0.05) or NCs (40.4±13.7, p < 0.001; MS vs NCs, p=ns) and were associated with pulmonary fibrosis. Conclusion. Immunoreactivity to UL83 HCMV is frequent and strong in patients with SSc, implying a possible pathogenic role for this disease. © Clinical and Experimental Rheumatology 2017. | en |
dc.language.iso | en | en |
dc.source | Clinical and Experimental Rheumatology | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020340627&partnerID=40&md5=560e25212b6f11449f71a3fecb3c8421 | |
dc.subject | autoantibody | en |
dc.subject | centromere protein A | en |
dc.subject | centromere protein B | en |
dc.subject | Cytomegalovirus antibody | en |
dc.subject | DNA directed RNA polymerase III | en |
dc.subject | fibrillarin | en |
dc.subject | immunoglobulin G antibody | en |
dc.subject | Ku antigen | en |
dc.subject | platelet derived growth factor receptor | en |
dc.subject | protein NOR90 | en |
dc.subject | protein PM Scl100 | en |
dc.subject | protein PM Scl75 | en |
dc.subject | protein Ro52 | en |
dc.subject | protein RP11 | en |
dc.subject | protein RP155 | en |
dc.subject | scl 70 antibody | en |
dc.subject | unclassified drug | en |
dc.subject | autoantibody | en |
dc.subject | cytomegalovirus matrix protein 65kDa | en |
dc.subject | matrix protein | en |
dc.subject | phosphoprotein | en |
dc.subject | adult | en |
dc.subject | age distribution | en |
dc.subject | aged | en |
dc.subject | antibody detection | en |
dc.subject | Article | en |
dc.subject | clinical feature | en |
dc.subject | controlled study | en |
dc.subject | female | en |
dc.subject | human | en |
dc.subject | Human cytomegalovirus | en |
dc.subject | immunoassay | en |
dc.subject | immunoreactivity | en |
dc.subject | lung fibrosis | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | multiple sclerosis | en |
dc.subject | priority journal | en |
dc.subject | protein expression | en |
dc.subject | sex difference | en |
dc.subject | systemic sclerosis | en |
dc.subject | very elderly | en |
dc.subject | Western blotting | en |
dc.subject | blood | en |
dc.subject | immunology | en |
dc.subject | middle aged | en |
dc.subject | multiple sclerosis | en |
dc.subject | systemic sclerosis | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Aged, 80 and over | en |
dc.subject | Autoantibodies | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Multiple Sclerosis | en |
dc.subject | Phosphoproteins | en |
dc.subject | Scleroderma, Systemic | en |
dc.subject | Viral Matrix Proteins | en |
dc.subject | Clinical and Experimental Rheumatology S.A.S. | en |
dc.title | Increased immunoreactivity against human cytomegalovirus UL83 in systemic sclerosis | en |
dc.type | journalArticle | en |
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