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Role of Oxidative Stress and Mitochondrial Dysfunction in Sepsis and Potential Therapies
dc.creator | Mantzarlis K., Tsolaki V., Zakynthinos E. | en |
dc.date.accessioned | 2023-01-31T08:57:00Z | |
dc.date.available | 2023-01-31T08:57:00Z | |
dc.date.issued | 2017 | |
dc.identifier | 10.1155/2017/5985209 | |
dc.identifier.issn | 19420900 | |
dc.identifier.uri | http://hdl.handle.net/11615/76301 | |
dc.description.abstract | Sepsis is one of the most important causes of death in intensive care units. Despite the fact that sepsis pathogenesis remains obscure, there is increasing evidence that oxidants and antioxidants play a key role. The imbalance of the abovementioned substances in favor of oxidants is called oxidative stress, and it contributes to sepsis process. The most important consequences are vascular permeability impairment, decreased cardiac performance, and mitochondrial malfunction leading to impaired respiration. Nitric oxide is perhaps the most important and well-studied oxidant. Selenium, Vitamin C, and 3N-Acetylcysteine among others are potential therapies for the restoration of redox balance in sepsis. Results from recent studies are promising, but there is a need for more human studies in a clinical setting for safety and efficiency evaluation. © 2017 Konstantinos Mantzarlis et al. | en |
dc.language.iso | en | en |
dc.source | Oxidative Medicine and Cellular Longevity | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85029178302&doi=10.1155%2f2017%2f5985209&partnerID=40&md5=811939358d60185ddb96825c7a4a416f | |
dc.subject | Intensive care units | en |
dc.subject | Nitric oxide | en |
dc.subject | Causes of death | en |
dc.subject | Clinical settings | en |
dc.subject | Mitochondrial dysfunction | en |
dc.subject | N-acetylcysteine | en |
dc.subject | Potential therapies | en |
dc.subject | Redox balances | en |
dc.subject | Safety and efficiencies | en |
dc.subject | Vascular permeability | en |
dc.subject | Oxidants | en |
dc.subject | acetylcysteine | en |
dc.subject | antioxidant | en |
dc.subject | ascorbic acid | en |
dc.subject | melatonin | en |
dc.subject | nitric oxide | en |
dc.subject | nitric oxide synthase inhibitor | en |
dc.subject | oxidizing agent | en |
dc.subject | selenium | en |
dc.subject | apoptosis | en |
dc.subject | disorders of mitochondrial functions | en |
dc.subject | heart disease | en |
dc.subject | human | en |
dc.subject | mitochondrion | en |
dc.subject | nonhuman | en |
dc.subject | oxidative stress | en |
dc.subject | Review | en |
dc.subject | sepsis | en |
dc.subject | animal | en |
dc.subject | metabolism | en |
dc.subject | pathology | en |
dc.subject | sepsis | en |
dc.subject | Diseases | en |
dc.subject | Oxidants | en |
dc.subject | Pathogens | en |
dc.subject | Stresses | en |
dc.subject | Animals | en |
dc.subject | Antioxidants | en |
dc.subject | Apoptosis | en |
dc.subject | Humans | en |
dc.subject | Mitochondria | en |
dc.subject | Nitric Oxide | en |
dc.subject | Oxidative Stress | en |
dc.subject | Sepsis | en |
dc.subject | Hindawi Limited | en |
dc.title | Role of Oxidative Stress and Mitochondrial Dysfunction in Sepsis and Potential Therapies | en |
dc.type | other | en |
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